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- W2912172181 abstract "Previous reports of POIT demonstrate a desensitization success rate of ∼80%. Between 01/01/09 and 06/30/18, we have treated 329 patients with POIT. The initial 270 patients have been reported. Based on our and others’ experience we have adjusted treatment age and the POIT process in an effort to increase the availability of POIT and improve the outcome. We contrast the outcomes of the initial and subsequently treated patients. Retrospective record review of patients receiving POIT approved by the North Texas IRB. POIT was administered according to modifications of previously reported protocols. 99% of the initial patients and 50% of the recent patients were >5yo. 82% of the initial patients (excluding 8 [2.9%] who transferred care) and 94% of the subsequent 67 patients reached their target peanut protein dose (TPPD). Epinephrine treated reactions occurred in 24% of the initial but only 7.5% of the subsequently treated patients. 14% of the initially treated patients but only 7.5% of the recent patients experienced eosinophilic esophagitis-like OIT-related GI symptoms. Among the recently treated patients there was no significant difference in adverse events between those <5yo and >5yo. Changes in POIT protocols and management experience from treating >325 patients has increased the likelihood of desensitization and decreased the rate of serious GI and systemic adverse events requiring epinephrine. These improvements cannot be explained by the inclusion of younger patients." @default.
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- W2912172181 date "2019-02-01" @default.
- W2912172181 modified "2023-10-17" @default.
- W2912172181 title "Changing The Outcomes Of Peanut Oral Immunotherapy (POIT)" @default.
- W2912172181 doi "https://doi.org/10.1016/j.jaci.2018.12.841" @default.
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