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- W2912172934 abstract "Microtubules are cytoskeletal polymers that play essential roles during multiple cellular processes. Dynamic nature of these polymers allows them to remodel the microtubule network spatially and temporally to fulfill their specific duties. Dynamic instability is a well known microtubule behavior in which both polymer ends independently switch between phases of growth and shrinkage. Earlier studies observed that microtubules can exhibit another mode of dynamics, a phenomenon called treadmilling, in which the growth rate at one end is comparable to the shrinkage rate of the other end. While microtubule dynamic instability has been widely studied, the conditions that lead to microtubule treadmilling are not well understood, and the relations between these two modes of microtubule dynamics are not well characterized. Here, we show that the dynamic instability and treadmilling of individual polymers coexist in vitro around 6uM tubulin in solution in the absence of microtubule associated proteins. We investigate different time scales to characterize the dynamic behavior of microtubules by calculating the net growth/shrinkage rate within the given time window and find that the microtubules exhibit treadmilling episodes in either direction, as well as growth or shrinkage at both ends. The treadmilling behavior arises due to the bias in the dynamic instability for a given time window, resulting in net shrinkage at one end and net growth at the other end. We find that, with tubulin alone, treadmilling towards the minus ends is more likely than towards the plus ends within time segments varying from 45 seconds to 10 minutes. By focusing on the microtubule dynamics at different time scales, this study provides a deeper understanding of the relations between dynamic instability and microtubule treadmilling." @default.
- W2912172934 created "2019-02-21" @default.
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- W2912172934 date "2019-02-01" @default.
- W2912172934 modified "2023-09-30" @default.
- W2912172934 title "Dynamic Instability and Treadmilling Coexist for In Vitro Microtubules" @default.
- W2912172934 doi "https://doi.org/10.1016/j.bpj.2018.11.869" @default.
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