FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912173065> ?p ?o ?g. }

• W2912173065 abstract "Fever of unknown origin (FUO) is one of the greatest challenges for clinicians and patients. There are more than 200 etiological agents of FUO, among these the most common is the role of infection, neoplasms, and diseases of connective tissue. The aim of the present study is to investigate the role of the infectious agents parvovirus B19 (B19V) and Coxiella burnetii (C. burnetii) in the development of fever of unknown origin by a set of immunoenzymatic and molecular methods.The present study included a total of 70 adult patients diagnosed with FUO and hospitalized in Bulgarian Hospitals. A control group of 26 healthy people were also included. Serological (indirect enzyme immunoassay test for detection of B19V and C. burnetii Ph. II specific IgM/IgG) and molecular (extraction and detection of infectious nucleic acids) methods were used.From all patients with FUO, a positive result for B19V-IgM was obtained in 18/70 (25.71%, 95% CI: 15.47 - 35.95) and the highest percentage was found in age groups 0 - 9 and 10 - 19 years. Protective B19V immunity and past viral infection was reported in 41/70 (58.57%, 95% CI: 47.03 - 70.11), and this percentage corresponded with the control group 16/26 (61.54%, 95% CI: 42.84 - 80.24). Anti-C. burnetii Ph. II-IgM was demonstrated in 13/70 (18.57%, 95% CI: 9.46 - 27.68). A relatively high percentage of affected patients were ≤ 40 years. Anti-C. burnetii Ph. II-IgG was detected in 24/70 (34.29%, 95% CI: 23.17 - 45.41). The control group has a 100% negative result for acute B19V and C. burnetii infection. A positive B19V-DNA result was obtained in 12/70 (17.14%, 95% CI: 8.31 - 25.97) patients. In 11/12 (91.67%) it was in combination with positive B19V-IgM marker. Of the total 70 sera tested, a positive PCR results for C. burnetii-DNA were obtained in 11 (15.71%, 95% CI: 7.18 - 24.24). According to clinical manifestation and concomitant symptoms, a high percentage of B19V and C. burnetii positives were associated with FUO and fever, headache, chills, and rash.It is of particular importance for a correct diagnosis of FUO to use a combined laboratory approach to prove acute or persistent infection and to test for a set of etiological agents." @default.
• W2912173065 created "2019-02-21" @default.
• W2912173065 creator A5015535196 @default.
• W2912173065 creator A5054962296 @default.
• W2912173065 creator A5064297435 @default.
• W2912173065 creator A5080490432 @default.
• W2912173065 date "2019-01-01" @default.
• W2912173065 modified "2023-09-26" @default.
• W2912173065 title "Combined Laboratory Approach to Detection of Parvovirus B19 and Coxiella Burnetii in Patients with Fever of Unknown Origin" @default.
• W2912173065 doi "https://doi.org/10.7754/clin.lab.2018.180617" @default.
• W2912173065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30775894" @default.
• W2912173065 hasPublicationYear "2019" @default.
• W2912173065 type Work @default.
• W2912173065 sameAs 2912173065 @default.
• W2912173065 citedByCount "2" @default.
• W2912173065 countsByYear W29121730652020 @default.
• W2912173065 countsByYear W29121730652021 @default.
• W2912173065 crossrefType "journal-article" @default.
• W2912173065 hasAuthorship W2912173065A5015535196 @default.
• W2912173065 hasAuthorship W2912173065A5054962296 @default.
• W2912173065 hasAuthorship W2912173065A5064297435 @default.
• W2912173065 hasAuthorship W2912173065A5080490432 @default.
• W2912173065 hasConcept C126322002 @default.
• W2912173065 hasConcept C159047783 @default.
• W2912173065 hasConcept C159654299 @default.
• W2912173065 hasConcept C203014093 @default.
• W2912173065 hasConcept C2522874641 @default.
• W2912173065 hasConcept C2776607032 @default.
• W2912173065 hasConcept C2779310458 @default.
• W2912173065 hasConcept C2779630601 @default.
• W2912173065 hasConcept C2780731870 @default.
• W2912173065 hasConcept C45189115 @default.
• W2912173065 hasConcept C71924100 @default.
• W2912173065 hasConceptScore W2912173065C126322002 @default.
• W2912173065 hasConceptScore W2912173065C159047783 @default.
• W2912173065 hasConceptScore W2912173065C159654299 @default.
• W2912173065 hasConceptScore W2912173065C203014093 @default.
• W2912173065 hasConceptScore W2912173065C2522874641 @default.
• W2912173065 hasConceptScore W2912173065C2776607032 @default.
• W2912173065 hasConceptScore W2912173065C2779310458 @default.
• W2912173065 hasConceptScore W2912173065C2779630601 @default.
• W2912173065 hasConceptScore W2912173065C2780731870 @default.
• W2912173065 hasConceptScore W2912173065C45189115 @default.
• W2912173065 hasConceptScore W2912173065C71924100 @default.
• W2912173065 hasLocation W29121730651 @default.
• W2912173065 hasLocation W29121730652 @default.
• W2912173065 hasOpenAccess W2912173065 @default.
• W2912173065 hasPrimaryLocation W29121730651 @default.
• W2912173065 hasRelatedWork W1978358946 @default.
• W2912173065 hasRelatedWork W1990497866 @default.
• W2912173065 hasRelatedWork W1992218427 @default.
• W2912173065 hasRelatedWork W2010625591 @default.
• W2912173065 hasRelatedWork W2050462438 @default.
• W2912173065 hasRelatedWork W2142322687 @default.
• W2912173065 hasRelatedWork W2292597657 @default.
• W2912173065 hasRelatedWork W2346398268 @default.
• W2912173065 hasRelatedWork W2411685474 @default.
• W2912173065 hasRelatedWork W2912173065 @default.
• W2912173065 isParatext "false" @default.
• W2912173065 isRetracted "false" @default.
• W2912173065 magId "2912173065" @default.
• W2912173065 workType "article" @default.