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• W2912173274 abstract "<b><i>Background:</i></b> A growing body of evidence has linked mental health outcomes to the gut microbiome. This has led to the investigation of the GI tract as a target for novel treatments and interventions for depression, including probiotic supplementation. Our recent pilot study provided the first evidence of probiotics improving symptoms of depression in treatment-naive depressed patients. To further support and expand upon this evidence, data from the pilot study were used to plan a 16-week, double-blind, randomized, placebo-controlled trial to assess the effects of probiotics on depression. Here, we report the protocol for this trial. <b><i>Methods:</i></b> Participants diagnosed with depression will orally consume a probiotic supplement containing <i>Lactobacillus helveticus</i> and <i>Bifidobacterium longum</i> or placebo once daily. Participants will undergo assessments measuring clinical outcomes using a battery of validated clinical scales and questionnaires. Sleep architecture and quality will be measured using polysomnography. Neuroimaging data will be collected using magnetic resonance imaging to examine functional and structural neurophysiological changes. Molecular data will be collected from blood, stool, and urine samples to examine cytokine levels and explore potential genes and proteins that may predict outcomes in depression. <b><i>Results:</i></b> We expect results to replicate and expand on our pilot data demonstrating that probiotics may be effective in alleviating symptoms of depression, and to find biomarkers that will predict these outcomes. <b><i>Conclusions:</i></b> The findings from this study will add to the growing body of research in this emerging field, which eventually may provide evidence for probiotics having a role in alleviating symptoms of depression." @default.
• W2912173274 created "2019-02-21" @default.
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• W2912173274 date "2019-02-13" @default.
• W2912173274 modified "2023-09-23" @default.
• W2912173274 title "The Effects of Probiotics on Symptoms of Depression: Protocol for a Double-Blind Randomized Placebo-Controlled Trial" @default.
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• W2912173274 doi "https://doi.org/10.1159/000496406" @default.
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