FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912174479> ?p ?o ?g. }

• W2912174479 endingPage "620" @default.
• W2912174479 startingPage "613" @default.
• W2912174479 abstract "Naproxen is a nonsteroidal anti-inflammatory drug that exhibits phototoxic side effects in humans, but its mechanism of phototoxicity is ambiguous. To uncover photophysical and photochemical reaction processes of naproxen, femtosecond to nanosecond transient absorption spectroscopies were employed to directly detect excited and transient states of naproxen upon UV irradiation in pure acetonitrile, acetonitrile:water 1:1, and acetonitrile:PBS 1:1 solutions. The transient absorption data together with time-dependent density functional theory analysis-predicted absorption spectra of selected intermediates were integrated to elucidate photochemical mechanisms for reactions of naproxen in different solutions. Femtosecond transient absorption results demonstrated that naproxen has two different photochemical pathways at the early delay time before the formation of final products in various solutions. In a pure acetonitrile solvent, naproxen undergoes charge transfer to solvent to generate a radical cation intermediate, which decarboxylates to generate a radical 2B intermediate. While in an acetonitrile:PBS 1:1 solution, naproxen predominantly deprotonates first and is promoted to the singlet exited state (1NPX–), which undergoes intersystem crossing to give rise to the lowest-lying triplet states (T1). T1 then undergoes decarboxylation reaction and produces a radical 2B species. Kinetic characterization of these processes reveals that the decarboxylation reaction in an acetonitrile:PBS 1:1 solution is faster than that in a pure acetonitrile solvent. Deep studies on photophysical and photochemical processes of NPX will aid us to better understand the toxicology mechanisms associated with NPX in different conditions." @default.
• W2912174479 created "2019-02-21" @default.
• W2912174479 creator A5043062274 @default.
• W2912174479 creator A5055783262 @default.
• W2912174479 creator A5076689560 @default.
• W2912174479 creator A5082147022 @default.
• W2912174479 date "2019-02-06" @default.
• W2912174479 modified "2023-09-25" @default.
• W2912174479 title "Unveiling the Photophysical and Photochemical Reaction Process of Naproxen via Ultrafast Femtosecond to Nanosecond Laser Flash Photolysis" @default.
• W2912174479 cites W1565253767 @default.
• W2912174479 cites W1828783709 @default.
• W2912174479 cites W1903010132 @default.
• W2912174479 cites W1968312227 @default.
• W2912174479 cites W1968512187 @default.
• W2912174479 cites W1968695355 @default.
• W2912174479 cites W1979030230 @default.
• W2912174479 cites W1992207139 @default.
• W2912174479 cites W1997151511 @default.
• W2912174479 cites W2010954640 @default.
• W2912174479 cites W2011935546 @default.
• W2912174479 cites W2012873284 @default.
• W2912174479 cites W2019758789 @default.
• W2912174479 cites W2034254472 @default.
• W2912174479 cites W2040576963 @default.
• W2912174479 cites W2058398316 @default.
• W2912174479 cites W2088576230 @default.
• W2912174479 cites W2106824077 @default.
• W2912174479 cites W2125257427 @default.
• W2912174479 cites W2136023241 @default.
• W2912174479 cites W2140950075 @default.
• W2912174479 cites W2254833392 @default.
• W2912174479 cites W2321900409 @default.
• W2912174479 cites W2604276953 @default.
• W2912174479 cites W2809429114 @default.
• W2912174479 cites W2893999721 @default.
• W2912174479 cites W4240408609 @default.
• W2912174479 cites W69612631 @default.
• W2912174479 doi "https://doi.org/10.1021/acs.chemrestox.8b00310" @default.
• W2912174479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30724062" @default.
• W2912174479 hasPublicationYear "2019" @default.
• W2912174479 type Work @default.
• W2912174479 sameAs 2912174479 @default.
• W2912174479 citedByCount "25" @default.
• W2912174479 countsByYear W29121744792019 @default.
• W2912174479 countsByYear W29121744792020 @default.
• W2912174479 countsByYear W29121744792021 @default.
• W2912174479 countsByYear W29121744792022 @default.
• W2912174479 countsByYear W29121744792023 @default.
• W2912174479 crossrefType "journal-article" @default.
• W2912174479 hasAuthorship W2912174479A5043062274 @default.
• W2912174479 hasAuthorship W2912174479A5055783262 @default.
• W2912174479 hasAuthorship W2912174479A5076689560 @default.
• W2912174479 hasAuthorship W2912174479A5082147022 @default.
• W2912174479 hasConcept C121332964 @default.
• W2912174479 hasConcept C125287762 @default.
• W2912174479 hasConcept C13472781 @default.
• W2912174479 hasConcept C142724271 @default.
• W2912174479 hasConcept C148898269 @default.
• W2912174479 hasConcept C159985019 @default.
• W2912174479 hasConcept C161790260 @default.
• W2912174479 hasConcept C178790620 @default.
• W2912174479 hasConcept C181500209 @default.
• W2912174479 hasConcept C185544564 @default.
• W2912174479 hasConcept C185592680 @default.
• W2912174479 hasConcept C192562407 @default.
• W2912174479 hasConcept C202751555 @default.
• W2912174479 hasConcept C204787440 @default.
• W2912174479 hasConcept C20639190 @default.
• W2912174479 hasConcept C2777463227 @default.
• W2912174479 hasConcept C2778115740 @default.
• W2912174479 hasConcept C2779953769 @default.
• W2912174479 hasConcept C2780595602 @default.
• W2912174479 hasConcept C32891209 @default.
• W2912174479 hasConcept C33062035 @default.
• W2912174479 hasConcept C55493867 @default.
• W2912174479 hasConcept C62520636 @default.
• W2912174479 hasConcept C71924100 @default.
• W2912174479 hasConcept C73978554 @default.
• W2912174479 hasConcept C75473681 @default.
• W2912174479 hasConcept C93391505 @default.
• W2912174479 hasConcept C95503338 @default.
• W2912174479 hasConceptScore W2912174479C121332964 @default.
• W2912174479 hasConceptScore W2912174479C125287762 @default.
• W2912174479 hasConceptScore W2912174479C13472781 @default.
• W2912174479 hasConceptScore W2912174479C142724271 @default.
• W2912174479 hasConceptScore W2912174479C148898269 @default.
• W2912174479 hasConceptScore W2912174479C159985019 @default.
• W2912174479 hasConceptScore W2912174479C161790260 @default.
• W2912174479 hasConceptScore W2912174479C178790620 @default.
• W2912174479 hasConceptScore W2912174479C181500209 @default.
• W2912174479 hasConceptScore W2912174479C185544564 @default.
• W2912174479 hasConceptScore W2912174479C185592680 @default.
• W2912174479 hasConceptScore W2912174479C192562407 @default.
• W2912174479 hasConceptScore W2912174479C202751555 @default.
• W2912174479 hasConceptScore W2912174479C204787440 @default.
• W2912174479 hasConceptScore W2912174479C20639190 @default.
• W2912174479 hasConceptScore W2912174479C2777463227 @default.
• W2912174479 hasConceptScore W2912174479C2778115740 @default.

• next