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• W2912176490 abstract "Acetyltransferase is a member of the transferase group responsible for transferring an acetyl group from acetyl-CoA to amino group of a histone lysine residue. Past efforts on histone acetylation monitoring involved biochemical analysis that do not provide spatiotemporal information in a dynamic format. We propose a novel approach to monitor acetyltransferase acetylation in live single cells using time correlated single photon counting fluorescence lifetime imaging (TCSPC-FLIM) with peptide biosensors. Utilizing 2D and 3D cultures we show that the peptide sensor has a specific response to acetyltransferase enzyme activity in a fluorescence lifetime dependent manner (P < 0.001). Our FLIM biosensor concept enables real-time longitudinal measurement of acetylation activity with high spatial and temporal resolution in live single cells to monitor cell function or evaluate drug effects to treat cancer or neurological diseases." @default.
• W2912176490 created "2019-02-21" @default.
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• W2912176490 date "2019-02-04" @default.
• W2912176490 modified "2023-09-26" @default.
• W2912176490 title "Epigenetic Process Monitoring in Live Cultures with Peptide Biosensors" @default.
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• W2912176490 doi "https://doi.org/10.1021/acssensors.8b01134" @default.
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