FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912178103> ?p ?o ?g. }

• W2912178103 endingPage "e6397" @default.
• W2912178103 startingPage "e6397" @default.
• W2912178103 abstract "Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play an important role in the competitive endogenous RNA (ceRNA) networks in that they regulate protein-coding gene expression by sponging microRNAs (miRNAs). However, the understanding of the ceRNA network in tongue squamous cell carcinoma (TSCC) remains limited.Expression profile data regarding mRNAs, miRNAs and lncRNAs as well as clinical information on 122 TSCC tissues and 15 normal controls from The Cancer Genome Atlas (TCGA) database were collected. We used the edgR package to identify differentially expressed mRNAs (DEmRNAs), lncRNAs (DElncRNAs) and miRNAs (DEmiRNAs) between TSCC samples and normal samples. In order to explore the functions of DEmRNAs, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed. Subsequently, a ceRNA network was established based on the identified DElncRNAs-DEmiRNAs and DEmiRNAs-DEmRNAs interactions. The RNAs within the ceRNA network were analyzed for their correlation with overall disease survival. Finally, lncRNAs were specifically analyzed for their correlation with clinical features in the included TSCC patient samples.A total of 1867 mRNAs, 828 lncRNAs and 81 miRNAs were identified as differentially expressed in TSCC tissues (-log 2fold change- ≥ 2; adjusted P value <0.01). The resulting ceRNA network included 16 mRNAs, 56 lncRNAs and 6 miRNAs. Ten out of the 56 lncRNAs were found to be associated with the overall survival in TSCC patients (P < 0.05); 10 lncRNAs were correlated with TSCC progression (P < 0.05).Our study deepens the understanding of ceRNA network regulatory mechanisms in TSCC. Furthermore, we identified ten lncRNAs (PART1, LINC00261, AL163952.1, C2orf48, FAM87A, LINC00052, LINC00472, STEAP3-AS1, TSPEAR-AS1 and ERVH48-1) as novel, potential prognostic biomarkers and therapeutic targets for TSCC." @default.
• W2912178103 created "2019-02-21" @default.
• W2912178103 creator A5030536674 @default.
• W2912178103 creator A5053410380 @default.
• W2912178103 creator A5068808455 @default.
• W2912178103 creator A5075363504 @default.
• W2912178103 creator A5078330347 @default.
• W2912178103 creator A5078396172 @default.
• W2912178103 date "2019-02-06" @default.
• W2912178103 modified "2023-10-06" @default.
• W2912178103 title "Comprehensive analysis of lncRNA-associated competing endogenous RNA network in tongue squamous cell carcinoma" @default.
• W2912178103 cites W1910504474 @default.
• W2912178103 cites W1977212573 @default.
• W2912178103 cites W1978506977 @default.
• W2912178103 cites W1978811100 @default.
• W2912178103 cites W2046387002 @default.
• W2912178103 cites W2066779073 @default.
• W2912178103 cites W2068517905 @default.
• W2912178103 cites W2074299339 @default.
• W2912178103 cites W2091161969 @default.
• W2912178103 cites W2109923675 @default.
• W2912178103 cites W2114104545 @default.
• W2912178103 cites W2116168949 @default.
• W2912178103 cites W2123250471 @default.
• W2912178103 cites W2123479813 @default.
• W2912178103 cites W2125548623 @default.
• W2912178103 cites W2134062584 @default.
• W2912178103 cites W2152280349 @default.
• W2912178103 cites W2169961966 @default.
• W2912178103 cites W2170552969 @default.
• W2912178103 cites W2174734928 @default.
• W2912178103 cites W2176164901 @default.
• W2912178103 cites W2219978888 @default.
• W2912178103 cites W2235523093 @default.
• W2912178103 cites W2336715782 @default.
• W2912178103 cites W2462296046 @default.
• W2912178103 cites W2464717012 @default.
• W2912178103 cites W2475324002 @default.
• W2912178103 cites W2507402545 @default.
• W2912178103 cites W2566314016 @default.
• W2912178103 cites W2570618306 @default.
• W2912178103 cites W2595012919 @default.
• W2912178103 cites W2602137703 @default.
• W2912178103 cites W2618051731 @default.
• W2912178103 cites W2732156606 @default.
• W2912178103 cites W2735202585 @default.
• W2912178103 cites W2737832093 @default.
• W2912178103 cites W2740415250 @default.
• W2912178103 cites W2765290226 @default.
• W2912178103 cites W2770441238 @default.
• W2912178103 cites W2778132317 @default.
• W2912178103 cites W2781338802 @default.
• W2912178103 cites W2781525129 @default.
• W2912178103 cites W2783142330 @default.
• W2912178103 cites W2783407769 @default.
• W2912178103 cites W2783763393 @default.
• W2912178103 cites W2787812668 @default.
• W2912178103 cites W2790646614 @default.
• W2912178103 cites W2790724719 @default.
• W2912178103 cites W2794227107 @default.
• W2912178103 cites W2794520973 @default.
• W2912178103 cites W2801724354 @default.
• W2912178103 cites W2801947677 @default.
• W2912178103 cites W2803781923 @default.
• W2912178103 cites W2804358054 @default.
• W2912178103 cites W2809136393 @default.
• W2912178103 cites W2809432913 @default.
• W2912178103 cites W2883331651 @default.
• W2912178103 cites W2887946619 @default.
• W2912178103 cites W2888070171 @default.
• W2912178103 cites W2890581759 @default.
• W2912178103 cites W2891953132 @default.
• W2912178103 cites W2894649362 @default.
• W2912178103 cites W2901142090 @default.
• W2912178103 cites W3024883285 @default.
• W2912178103 doi "https://doi.org/10.7717/peerj.6397" @default.
• W2912178103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6368841" @default.
• W2912178103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30755833" @default.
• W2912178103 hasPublicationYear "2019" @default.
• W2912178103 type Work @default.
• W2912178103 sameAs 2912178103 @default.
• W2912178103 citedByCount "26" @default.
• W2912178103 countsByYear W29121781032019 @default.
• W2912178103 countsByYear W29121781032020 @default.
• W2912178103 countsByYear W29121781032021 @default.
• W2912178103 countsByYear W29121781032022 @default.
• W2912178103 countsByYear W29121781032023 @default.
• W2912178103 crossrefType "journal-article" @default.
• W2912178103 hasAuthorship W2912178103A5030536674 @default.
• W2912178103 hasAuthorship W2912178103A5053410380 @default.
• W2912178103 hasAuthorship W2912178103A5068808455 @default.
• W2912178103 hasAuthorship W2912178103A5075363504 @default.
• W2912178103 hasAuthorship W2912178103A5078330347 @default.
• W2912178103 hasAuthorship W2912178103A5078396172 @default.
• W2912178103 hasBestOaLocation W29121781031 @default.
• W2912178103 hasConcept C104317684 @default.
• W2912178103 hasConcept C10515644 @default.
• W2912178103 hasConcept C126322002 @default.

• next