Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912178380> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2912178380 endingPage "214" @default.
- W2912178380 startingPage "209" @default.
- W2912178380 abstract "Aims: This study was designed to develop a high-resolution melting (HRM) analysis-based cardiovascular (CV) pharmacogenetics (PGx) genotyping panel for the Canon DNA Genetic Analyzer multiplex genotyping platform and cross-validate its performance with the TaqMan®-based OpenArray® method. Methods: The CV PGx genotyping panel containing 17 single nucleotide polymorphisms (SNPs) selected from 5 genes (CYP2C9, CYP2C19, CYP4F2, SLCO1B1, and VKORC1) and the CYP2C cluster was used to compare genotyping results between analysis methods. Genomic DNA from 223 clinical samples was used to genotype the 17 SNPs on the Canon DNA Genetic Analyzer and TaqMan OpenArray Quant Studio Real-Time PCR (polymerase chain reaction) System. Results: The concordance between the Canon DNA analyzer and TaqMan-based OpenArray genotyping results for the 17 SNPs ranged from 99.10% to 100% where SNPs (rs4244285, rs12248560, rs4986893, rs72552267, rs28399504, rs4149056, rs28371686, rs9332131, rs72558189, rs9923231, rs12777823), (rs41291556, rs1799853, rs7900194, rs28371685, rs2108622), and (rs1057910) showed 100%, 99.60%, and 99.10% concordance, respectively. Conclusion: These results show that the HRM analysis-based CV PGx genotyping panel performed well when compared with TaqMan-based OpenArray. The multiple genetic variant testing capability, efficient turnaround time and reproducibility of both assays formats suggest that the PGx panel with the DNA analyzer or other real-time PCR instruments with HRM assay analysis capability can be used for PGx testing in both research and clinical practice settings." @default.
- W2912178380 created "2019-02-21" @default.
- W2912178380 creator A5050129298 @default.
- W2912178380 creator A5061865147 @default.
- W2912178380 creator A5070710719 @default.
- W2912178380 creator A5076056712 @default.
- W2912178380 creator A5087174396 @default.
- W2912178380 date "2019-03-01" @default.
- W2912178380 modified "2023-09-25" @default.
- W2912178380 title "Development and Cross-Validation of High-Resolution Melting Analysis-Based Cardiovascular Pharmacogenetics Genotyping Panel" @default.
- W2912178380 cites W1604547439 @default.
- W2912178380 cites W1953684814 @default.
- W2912178380 cites W1968604782 @default.
- W2912178380 cites W1990982620 @default.
- W2912178380 cites W1997100483 @default.
- W2912178380 cites W2002103344 @default.
- W2912178380 cites W2025668168 @default.
- W2912178380 cites W2074183872 @default.
- W2912178380 cites W2083728759 @default.
- W2912178380 cites W2100990361 @default.
- W2912178380 cites W2110513645 @default.
- W2912178380 cites W2129271730 @default.
- W2912178380 cites W2139681313 @default.
- W2912178380 cites W2143559628 @default.
- W2912178380 cites W2156876112 @default.
- W2912178380 cites W2226311111 @default.
- W2912178380 cites W2295666607 @default.
- W2912178380 cites W2551787446 @default.
- W2912178380 cites W2588108371 @default.
- W2912178380 cites W2590053815 @default.
- W2912178380 cites W2597078841 @default.
- W2912178380 cites W2611308057 @default.
- W2912178380 cites W2729092515 @default.
- W2912178380 cites W2757093235 @default.
- W2912178380 cites W2766537985 @default.
- W2912178380 cites W2779999552 @default.
- W2912178380 cites W2424350511 @default.
- W2912178380 doi "https://doi.org/10.1089/gtmb.2018.0298" @default.
- W2912178380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30758238" @default.
- W2912178380 hasPublicationYear "2019" @default.
- W2912178380 type Work @default.
- W2912178380 sameAs 2912178380 @default.
- W2912178380 citedByCount "3" @default.
- W2912178380 countsByYear W29121783802020 @default.
- W2912178380 countsByYear W29121783802021 @default.
- W2912178380 crossrefType "journal-article" @default.
- W2912178380 hasAuthorship W2912178380A5050129298 @default.
- W2912178380 hasAuthorship W2912178380A5061865147 @default.
- W2912178380 hasAuthorship W2912178380A5070710719 @default.
- W2912178380 hasAuthorship W2912178380A5076056712 @default.
- W2912178380 hasAuthorship W2912178380A5087174396 @default.
- W2912178380 hasConcept C104317684 @default.
- W2912178380 hasConcept C135763542 @default.
- W2912178380 hasConcept C143660080 @default.
- W2912178380 hasConcept C153209595 @default.
- W2912178380 hasConcept C160798450 @default.
- W2912178380 hasConcept C163691529 @default.
- W2912178380 hasConcept C31467283 @default.
- W2912178380 hasConcept C34372108 @default.
- W2912178380 hasConcept C49105822 @default.
- W2912178380 hasConcept C54355233 @default.
- W2912178380 hasConcept C70721500 @default.
- W2912178380 hasConcept C86803240 @default.
- W2912178380 hasConceptScore W2912178380C104317684 @default.
- W2912178380 hasConceptScore W2912178380C135763542 @default.
- W2912178380 hasConceptScore W2912178380C143660080 @default.
- W2912178380 hasConceptScore W2912178380C153209595 @default.
- W2912178380 hasConceptScore W2912178380C160798450 @default.
- W2912178380 hasConceptScore W2912178380C163691529 @default.
- W2912178380 hasConceptScore W2912178380C31467283 @default.
- W2912178380 hasConceptScore W2912178380C34372108 @default.
- W2912178380 hasConceptScore W2912178380C49105822 @default.
- W2912178380 hasConceptScore W2912178380C54355233 @default.
- W2912178380 hasConceptScore W2912178380C70721500 @default.
- W2912178380 hasConceptScore W2912178380C86803240 @default.
- W2912178380 hasIssue "3" @default.
- W2912178380 hasLocation W29121783801 @default.
- W2912178380 hasLocation W29121783802 @default.
- W2912178380 hasOpenAccess W2912178380 @default.
- W2912178380 hasPrimaryLocation W29121783801 @default.
- W2912178380 hasRelatedWork W1999806424 @default.
- W2912178380 hasRelatedWork W2028537606 @default.
- W2912178380 hasRelatedWork W2164332050 @default.
- W2912178380 hasRelatedWork W2362025396 @default.
- W2912178380 hasRelatedWork W2381171520 @default.
- W2912178380 hasRelatedWork W2384640661 @default.
- W2912178380 hasRelatedWork W2415911775 @default.
- W2912178380 hasRelatedWork W2419346078 @default.
- W2912178380 hasRelatedWork W3029208462 @default.
- W2912178380 hasRelatedWork W4296620168 @default.
- W2912178380 hasVolume "23" @default.
- W2912178380 isParatext "false" @default.
- W2912178380 isRetracted "false" @default.
- W2912178380 magId "2912178380" @default.
- W2912178380 workType "article" @default.