FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912178523> ?p ?o ?g. }

• W2912178523 endingPage "60" @default.
• W2912178523 startingPage "51" @default.
• W2912178523 abstract "Obesity, a condition most commonly associated with hyper-leptinemia, is also characterized by increased expression of autophagy genes and likely autophagic activity in human adipose tissue (AT). Indeed, circulating leptin levels were previously shown to positively associate with the expression levels of autophagy genes such as Autophagy related gene-5 (ATG5). Here we hypothesized that leptin acts in an autocrine-paracrine manner to increase autophagy in two major AT cell populations, adipocytes and macrophages. We followed the dynamics of autophagosomes following acute leptin administration with or without a leptin receptor antagonist (SMLA) using high-throughput live-cell imaging in murine epididymal adipocyte and macrophage (RAW264.7) cell-lines. In macrophages leptin exerted only a mild effect on autophagy dynamics, tending to attenuate autophagosomes growth rate. In contrast, leptin-treated adipocytes exhibited a moderate, ~20% increase in the rate of autophagosome growth, an effect that was blocked by SMLA. This finding corresponded to mild increases in mRNA and protein expression of key autophagy genes. Interestingly, a long-lived proteins degradation assay uncovered a robust, >2-fold leptin-mediated stimulation of the autophagy/lysosome-related (bafilomycin-inhibited) activity, which was entirely blocked by SMLA. Collectively, leptin regulates autophagy in a cell-type specific manner. In adipocytes, autophagosome dynamics is moderately enhanced, but even more pronounced stimulation is seen in autophagy-related long-lived protein degradation. These findings suggest a causal link between obesity-associated hyperleptinemia and elevated adipocyte and AT autophagy-related processes." @default.
• W2912178523 created "2019-02-21" @default.
• W2912178523 creator A5006900936 @default.
• W2912178523 creator A5008490135 @default.
• W2912178523 creator A5014175003 @default.
• W2912178523 creator A5014581353 @default.
• W2912178523 creator A5014740581 @default.
• W2912178523 creator A5068943447 @default.
• W2912178523 creator A5073471236 @default.
• W2912178523 creator A5081642122 @default.
• W2912178523 date "2019-01-02" @default.
• W2912178523 modified "2023-09-26" @default.
• W2912178523 title "Leptin stimulates autophagy/lysosome-related degradation of long-lived proteins in adipocytes" @default.
• W2912178523 cites W1512227914 @default.
• W2912178523 cites W1525943215 @default.
• W2912178523 cites W1571499367 @default.
• W2912178523 cites W1706150252 @default.
• W2912178523 cites W1981464590 @default.
• W2912178523 cites W1987769185 @default.
• W2912178523 cites W1990681455 @default.
• W2912178523 cites W1991136352 @default.
• W2912178523 cites W2004196710 @default.
• W2912178523 cites W2008869160 @default.
• W2912178523 cites W2009128541 @default.
• W2912178523 cites W2028260889 @default.
• W2912178523 cites W2034218807 @default.
• W2912178523 cites W2039840615 @default.
• W2912178523 cites W2051372717 @default.
• W2912178523 cites W2062028090 @default.
• W2912178523 cites W2062754223 @default.
• W2912178523 cites W2063255492 @default.
• W2912178523 cites W2076633494 @default.
• W2912178523 cites W2076667569 @default.
• W2912178523 cites W2095008495 @default.
• W2912178523 cites W2102690338 @default.
• W2912178523 cites W2105248147 @default.
• W2912178523 cites W2109058559 @default.
• W2912178523 cites W2111990033 @default.
• W2912178523 cites W2124257857 @default.
• W2912178523 cites W2125510262 @default.
• W2912178523 cites W2135552411 @default.
• W2912178523 cites W2147062583 @default.
• W2912178523 cites W2154846778 @default.
• W2912178523 cites W2167117819 @default.
• W2912178523 cites W2170404804 @default.
• W2912178523 cites W2280593936 @default.
• W2912178523 cites W2331769226 @default.
• W2912178523 cites W2334337188 @default.
• W2912178523 cites W2409668816 @default.
• W2912178523 cites W2530974147 @default.
• W2912178523 cites W2591981899 @default.
• W2912178523 cites W2670125714 @default.
• W2912178523 cites W2752326209 @default.
• W2912178523 cites W2766498990 @default.
• W2912178523 cites W2769658100 @default.
• W2912178523 cites W2780929231 @default.
• W2912178523 cites W2790832382 @default.
• W2912178523 cites W2792516799 @default.
• W2912178523 cites W2793972197 @default.
• W2912178523 cites W2795030274 @default.
• W2912178523 cites W2800923282 @default.
• W2912178523 doi "https://doi.org/10.1080/21623945.2019.1569447" @default.
• W2912178523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6768270" @default.
• W2912178523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30676227" @default.
• W2912178523 hasPublicationYear "2019" @default.
• W2912178523 type Work @default.
• W2912178523 sameAs 2912178523 @default.
• W2912178523 citedByCount "13" @default.
• W2912178523 countsByYear W29121785232020 @default.
• W2912178523 countsByYear W29121785232021 @default.
• W2912178523 countsByYear W29121785232022 @default.
• W2912178523 countsByYear W29121785232023 @default.
• W2912178523 crossrefType "journal-article" @default.
• W2912178523 hasAuthorship W2912178523A5006900936 @default.
• W2912178523 hasAuthorship W2912178523A5008490135 @default.
• W2912178523 hasAuthorship W2912178523A5014175003 @default.
• W2912178523 hasAuthorship W2912178523A5014581353 @default.
• W2912178523 hasAuthorship W2912178523A5014740581 @default.
• W2912178523 hasAuthorship W2912178523A5068943447 @default.
• W2912178523 hasAuthorship W2912178523A5073471236 @default.
• W2912178523 hasAuthorship W2912178523A5081642122 @default.
• W2912178523 hasBestOaLocation W29121785231 @default.
• W2912178523 hasConcept C126322002 @default.
• W2912178523 hasConcept C134018914 @default.
• W2912178523 hasConcept C168296220 @default.
• W2912178523 hasConcept C170493617 @default.
• W2912178523 hasConcept C171089720 @default.
• W2912178523 hasConcept C181199279 @default.
• W2912178523 hasConcept C185592680 @default.
• W2912178523 hasConcept C190283241 @default.
• W2912178523 hasConcept C203522944 @default.
• W2912178523 hasConcept C2776175234 @default.
• W2912178523 hasConcept C2780216420 @default.
• W2912178523 hasConcept C2780613262 @default.
• W2912178523 hasConcept C2781000418 @default.
• W2912178523 hasConcept C511355011 @default.
• W2912178523 hasConcept C55493867 @default.
• W2912178523 hasConcept C71924100 @default.

• next