FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912179901> ?p ?o ?g. }

• W2912179901 endingPage "533" @default.
• W2912179901 startingPage "523" @default.
• W2912179901 abstract "Regenerating a functional dental pulp in the pulpectomized root canal has been recently proposed as a novel therapeutic strategy in dentistry. To reach this goal, designing an appropriate scaffold able to prevent the growth of residual endodontic bacteria, while supporting dental pulp tissue neoformation, is needed. Our aim was to create an innovative cellularized fibrin hydrogel supplemented with chitosan to confer this hydrogel antibacterial property. Several fibrin–chitosan formulations were first screened by rheological analyses, and the most appropriate for clinical use was then studied in terms of microstructure (by scanning electron microscopy), antimicrobial effect (analysis of Enterococcus fæcalis growth), dental pulp-mesenchymal stem/stromal cell (DP-MSC) viability and spreading after 7 days of culture (LiveDead® test), DP-MSC ultrastructure and extracellular matrix deposition (transmission electron microscopy), and DP-MSC proliferation and collagen production (RT-qPCR and immunohistochemistry). A formulation associating 10 mg/mL fibrinogen and 0.5% (w/w), 40% degree of acetylation, medium molar mass chitosan was found to be relevant in order to forming a fibrin–chitosan hydrogel at cytocompatible pH (# 7.2). Comparative analysis of fibrin-alone and fibrin–chitosan hydrogels revealed a potent antibacterial effect of the chitosan in the fibrin network, and similar DP-MSC viability, fibroblast-like morphology, proliferation rate and type I/III collagen production capacity. These results indicate that incorporating chitosan within a fibrin hydrogel would be beneficial to promote human DP tissue neoformation thanks to chitosan antibacterial effect and the absence of significant detrimental effect of chitosan on dental pulp cell morphology, viability, proliferation and collagenous matrix production." @default.
• W2912179901 created "2019-02-21" @default.
• W2912179901 creator A5007824739 @default.
• W2912179901 creator A5009956396 @default.
• W2912179901 creator A5031436798 @default.
• W2912179901 creator A5032846123 @default.
• W2912179901 creator A5046597795 @default.
• W2912179901 creator A5047158342 @default.
• W2912179901 creator A5054879613 @default.
• W2912179901 creator A5057355995 @default.
• W2912179901 creator A5062627265 @default.
• W2912179901 creator A5070639075 @default.
• W2912179901 date "2019-04-01" @default.
• W2912179901 modified "2023-10-16" @default.
• W2912179901 title "Design and characterization of a chitosan-enriched fibrin hydrogel for human dental pulp regeneration" @default.
• W2912179901 cites W1251253606 @default.
• W2912179901 cites W136462347 @default.
• W2912179901 cites W1848365318 @default.
• W2912179901 cites W1974384763 @default.
• W2912179901 cites W1978593181 @default.
• W2912179901 cites W2014401413 @default.
• W2912179901 cites W2016154231 @default.
• W2912179901 cites W2023989480 @default.
• W2912179901 cites W2025730257 @default.
• W2912179901 cites W2032256033 @default.
• W2912179901 cites W2038469051 @default.
• W2912179901 cites W2046601429 @default.
• W2912179901 cites W2053143106 @default.
• W2912179901 cites W2055495773 @default.
• W2912179901 cites W2073571039 @default.
• W2912179901 cites W2074951535 @default.
• W2912179901 cites W2076581211 @default.
• W2912179901 cites W2102069687 @default.
• W2912179901 cites W2107277218 @default.
• W2912179901 cites W2118305071 @default.
• W2912179901 cites W2121039238 @default.
• W2912179901 cites W2125581457 @default.
• W2912179901 cites W2125684965 @default.
• W2912179901 cites W2129914195 @default.
• W2912179901 cites W2129928732 @default.
• W2912179901 cites W2145568935 @default.
• W2912179901 cites W2160221064 @default.
• W2912179901 cites W2169855755 @default.
• W2912179901 cites W2230005681 @default.
• W2912179901 cites W2298901024 @default.
• W2912179901 cites W2336550680 @default.
• W2912179901 cites W2339780399 @default.
• W2912179901 cites W2400608037 @default.
• W2912179901 cites W2402389012 @default.
• W2912179901 cites W2500767406 @default.
• W2912179901 cites W2525806127 @default.
• W2912179901 cites W2551943712 @default.
• W2912179901 cites W2567313158 @default.
• W2912179901 cites W2591796324 @default.
• W2912179901 cites W2606890922 @default.
• W2912179901 cites W2614111790 @default.
• W2912179901 cites W2617688245 @default.
• W2912179901 cites W2621143848 @default.
• W2912179901 cites W2662243568 @default.
• W2912179901 cites W2738615382 @default.
• W2912179901 cites W2742895762 @default.
• W2912179901 cites W2760316295 @default.
• W2912179901 cites W2772756729 @default.
• W2912179901 doi "https://doi.org/10.1016/j.dental.2019.01.018" @default.
• W2912179901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712823" @default.
• W2912179901 hasPublicationYear "2019" @default.
• W2912179901 type Work @default.
• W2912179901 sameAs 2912179901 @default.
• W2912179901 citedByCount "56" @default.
• W2912179901 countsByYear W29121799012019 @default.
• W2912179901 countsByYear W29121799012020 @default.
• W2912179901 countsByYear W29121799012021 @default.
• W2912179901 countsByYear W29121799012022 @default.
• W2912179901 countsByYear W29121799012023 @default.
• W2912179901 crossrefType "journal-article" @default.
• W2912179901 hasAuthorship W2912179901A5007824739 @default.
• W2912179901 hasAuthorship W2912179901A5009956396 @default.
• W2912179901 hasAuthorship W2912179901A5031436798 @default.
• W2912179901 hasAuthorship W2912179901A5032846123 @default.
• W2912179901 hasAuthorship W2912179901A5046597795 @default.
• W2912179901 hasAuthorship W2912179901A5047158342 @default.
• W2912179901 hasAuthorship W2912179901A5054879613 @default.
• W2912179901 hasAuthorship W2912179901A5057355995 @default.
• W2912179901 hasAuthorship W2912179901A5062627265 @default.
• W2912179901 hasAuthorship W2912179901A5070639075 @default.
• W2912179901 hasBestOaLocation W29121799011 @default.
• W2912179901 hasConcept C108586683 @default.
• W2912179901 hasConcept C136229726 @default.
• W2912179901 hasConcept C1491633281 @default.
• W2912179901 hasConcept C185592680 @default.
• W2912179901 hasConcept C188027245 @default.
• W2912179901 hasConcept C188442228 @default.
• W2912179901 hasConcept C189165786 @default.
• W2912179901 hasConcept C192562407 @default.
• W2912179901 hasConcept C198826908 @default.
• W2912179901 hasConcept C199343813 @default.
• W2912179901 hasConcept C202751555 @default.
• W2912179901 hasConcept C203014093 @default.

• next