Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912181324> ?p ?o ?g. }
- W2912181324 endingPage "251" @default.
- W2912181324 startingPage "240" @default.
- W2912181324 abstract "Radiation retinopathy is a serious vision-impairing complication of radiation therapy used to treat ocular tumors. Characterized by retinal vasculopathy and subsequent retinal damage, the first sign of radiation retinopathy is the preferential loss of vascular endothelial cells. Ensuing ischemia leads to retinal degradation and late stage neovascularization. Despite the established disease progression, the pathophysiology and cellular mechanisms contributing to radiation retinopathy remain unclear. Clinical experience and basic research for other retinal vasculopathies, such as diabetic retinopathy and retinopathy of prematurity, can inform our understanding of radiation retinopathy; however, the literature investigating the fundamental mechanisms in radiation retinopathy is limited. Treatment trials have shown modest success but, ultimately, fail to address the cellular events that initiate radiation retinopathy. Animal models of radiation retinopathy could provide means to identify effective therapies. Here, we review the literature for all animal models of radiation retinopathy, summarize anatomical highlights pertaining to animal models, identify additional physiological factors to consider when investigating radiation retinopathy, and explore the use of clinically relevant tests for studying in vivo models of radiation retinopathy. We encourage further investigation into the mechanistic characterization of radiation retinopathy in the hope of discovering novel treatments." @default.
- W2912181324 created "2019-02-21" @default.
- W2912181324 creator A5024126113 @default.
- W2912181324 creator A5050730964 @default.
- W2912181324 creator A5062088249 @default.
- W2912181324 creator A5063757655 @default.
- W2912181324 creator A5066195946 @default.
- W2912181324 creator A5082597136 @default.
- W2912181324 creator A5087116780 @default.
- W2912181324 date "2019-04-01" @default.
- W2912181324 modified "2023-09-25" @default.
- W2912181324 title "Animal models of radiation retinopathy – From teletherapy to brachytherapy" @default.
- W2912181324 cites W1526361618 @default.
- W2912181324 cites W1536434541 @default.
- W2912181324 cites W1907005829 @default.
- W2912181324 cites W1963713495 @default.
- W2912181324 cites W1969388768 @default.
- W2912181324 cites W1976588313 @default.
- W2912181324 cites W1979217562 @default.
- W2912181324 cites W1979673214 @default.
- W2912181324 cites W1981579827 @default.
- W2912181324 cites W1985360501 @default.
- W2912181324 cites W1988263476 @default.
- W2912181324 cites W1989521988 @default.
- W2912181324 cites W1990530372 @default.
- W2912181324 cites W1995556495 @default.
- W2912181324 cites W1996362416 @default.
- W2912181324 cites W1996913726 @default.
- W2912181324 cites W2001511522 @default.
- W2912181324 cites W2001707539 @default.
- W2912181324 cites W2003775520 @default.
- W2912181324 cites W2005286362 @default.
- W2912181324 cites W2015909326 @default.
- W2912181324 cites W2016133918 @default.
- W2912181324 cites W2022636024 @default.
- W2912181324 cites W2030168485 @default.
- W2912181324 cites W2031928920 @default.
- W2912181324 cites W2035799684 @default.
- W2912181324 cites W2037996600 @default.
- W2912181324 cites W2038237418 @default.
- W2912181324 cites W2043420707 @default.
- W2912181324 cites W2043691744 @default.
- W2912181324 cites W2044112280 @default.
- W2912181324 cites W2044402553 @default.
- W2912181324 cites W2045572497 @default.
- W2912181324 cites W2045903651 @default.
- W2912181324 cites W2046592817 @default.
- W2912181324 cites W2047302416 @default.
- W2912181324 cites W2047594195 @default.
- W2912181324 cites W2049650439 @default.
- W2912181324 cites W2052618119 @default.
- W2912181324 cites W2053745314 @default.
- W2912181324 cites W2054826402 @default.
- W2912181324 cites W2056649427 @default.
- W2912181324 cites W2060606925 @default.
- W2912181324 cites W2062448514 @default.
- W2912181324 cites W2063149848 @default.
- W2912181324 cites W2064147903 @default.
- W2912181324 cites W2065659718 @default.
- W2912181324 cites W2069805333 @default.
- W2912181324 cites W2071297515 @default.
- W2912181324 cites W2073573774 @default.
- W2912181324 cites W2076174202 @default.
- W2912181324 cites W2082843263 @default.
- W2912181324 cites W2084086614 @default.
- W2912181324 cites W2084655653 @default.
- W2912181324 cites W2087420292 @default.
- W2912181324 cites W2087907624 @default.
- W2912181324 cites W2089772771 @default.
- W2912181324 cites W2089935553 @default.
- W2912181324 cites W2090608463 @default.
- W2912181324 cites W2091488437 @default.
- W2912181324 cites W2097512974 @default.
- W2912181324 cites W2097679300 @default.
- W2912181324 cites W2105155178 @default.
- W2912181324 cites W2112907172 @default.
- W2912181324 cites W2112957192 @default.
- W2912181324 cites W2122336651 @default.
- W2912181324 cites W2123865741 @default.
- W2912181324 cites W2135770481 @default.
- W2912181324 cites W2138222951 @default.
- W2912181324 cites W2138540621 @default.
- W2912181324 cites W2139995793 @default.
- W2912181324 cites W2143091201 @default.
- W2912181324 cites W2143829435 @default.
- W2912181324 cites W2145798539 @default.
- W2912181324 cites W2149241796 @default.
- W2912181324 cites W2150030229 @default.
- W2912181324 cites W2156018975 @default.
- W2912181324 cites W2156259771 @default.
- W2912181324 cites W2160243079 @default.
- W2912181324 cites W2167176307 @default.
- W2912181324 cites W2168968288 @default.
- W2912181324 cites W2170079300 @default.
- W2912181324 cites W2212820445 @default.
- W2912181324 cites W2238854720 @default.
- W2912181324 cites W2242799666 @default.
- W2912181324 cites W2316365390 @default.