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• W2912181667 abstract "Abstract Objective To determine whether the rich-club organization, essential for information transport in the human connectome, is an important biomarker of functional outcome after acute ischemic stroke (AIS). Methods Consecutive AIS patients (N=344) with acute brain magnetic resonance imaging (MRI) (<48 hours) were eligible for this study. Each patient underwent a clinical MRI protocol, which included diffusion weighted imaging (DWI). All DWIs were registered to a template on which rich-club regions have been defined. Using manual outlines of stroke lesions, we automatically counted the number of affected rich-club regions and assessed its effect on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS; obtained at 90 days post-stroke) scores through ordinal regression. Results Of 344 patients (median age 65, inter-quartile range 54-76 years) with a median DWI lesion volume (DWIv) of 3cc, 64% were male. We established that an increase in number of rich-club regions affected by a stroke increases the odds of poor stroke outcome, measured by NIHSS (OR: 1.77, 95%CI 1.41-2.21) and mRS (OR: 1.38, 95%CI 1.11-1.73). Additionally, we demonstrated that the OR exceeds traditional markers, such as DWIv (OR NIHSS 1.08, 95%CI 1.06-1.11; OR mRs 1.05, 95%CI 1.03-1.07) and age (OR NIHSS 1.03, 95%CI 1.01-1.05; OR mRs 1.05, 95%CI 1.03-1.07). Conclusion In this proof-of-concept study, the number of rich-club nodes affected by a stroke lesion presents a translational biomarker of stroke outcome, which can be readily assessed using standard clinical AIS imaging protocols and considered in functional outcome prediction models beyond traditional factors." @default.
• W2912181667 created "2019-02-21" @default.
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• W2912181667 date "2019-02-10" @default.
• W2912181667 modified "2023-09-26" @default.
• W2912181667 title "Rich-Club organization: an important determinant of functional outcome after acute ischemic stroke" @default.
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• W2912181667 doi "https://doi.org/10.1101/545897" @default.
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