FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912182643> ?p ?o ?g. }

• W2912182643 endingPage "280" @default.
• W2912182643 startingPage "272" @default.
• W2912182643 abstract "Abstract Introduction Assess survival of patients with anaplastic glioma ( AG ) and the relationship to molecular subtype. Methods Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse‐free survival ( RFS ) and overall survival ( OS ). Isocitrate dehydrogenase ( IDH ) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type ( AA wt), anaplastic astrocytoma IDH mutated ( AA mut), anaplastic oligodendroglioma ( AOD ) or other glial tumour ( OTH ). Kaplan‐Meier estimates of survival distribution were calculated for the primary endpoint of overall survival and Log‐rank test used to determine associated factors. Results One hundred and fifty‐six patients were included with median follow‐up for survivors of 4.7 years. Fifty‐six per cent were managed after initial diagnosis, whilst 18% received IMRT at second or later relapse. Seventy‐three per cent had temozolomide as part of initial therapy. A total of 118 or 75% of patients had IDH mutated glioma, of which 61 were AOD and 57 AA mut. There were 68 relapses and 52 deaths for a 6yr RFS of 51.2% and 6yr OS of 62.5%. AA wt was associated with worse survival ( P < 0.001); and delay of RT until second or later relapse ( P = 0.03). Within the 118 patients with IDH mutated tumours, 6yr OS for AOD and AA mut were 90.0% and 62.5%, respectively ( P = 0.003). Also two or more craniotomies ( P < 0.001), delayed RT ( P = 0.006) and age <40 years ( P = 0.022) were associated with worse survival on univariate analysis but only AA mut subtype and number of craniotomies on multivariate analysis. Conclusion Within AG , molecular classification predicts for survival, and should influence current decision‐making." @default.
• W2912182643 created "2019-02-21" @default.
• W2912182643 creator A5004781307 @default.
• W2912182643 creator A5009478113 @default.
• W2912182643 creator A5056401056 @default.
• W2912182643 creator A5056408183 @default.
• W2912182643 creator A5057619248 @default.
• W2912182643 creator A5061869022 @default.
• W2912182643 creator A5063111253 @default.
• W2912182643 creator A5064296968 @default.
• W2912182643 creator A5066896961 @default.
• W2912182643 creator A5078281474 @default.
• W2912182643 creator A5083131273 @default.
• W2912182643 creator A5085797205 @default.
• W2912182643 creator A5091740838 @default.
• W2912182643 date "2019-01-24" @default.
• W2912182643 modified "2023-09-23" @default.
• W2912182643 title "Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management" @default.
• W2912182643 cites W1939176028 @default.
• W2912182643 cites W1959628099 @default.
• W2912182643 cites W1978881309 @default.
• W2912182643 cites W2001493754 @default.
• W2912182643 cites W2003097798 @default.
• W2912182643 cites W2012669738 @default.
• W2912182643 cites W2036044314 @default.
• W2912182643 cites W2040827479 @default.
• W2912182643 cites W2094537892 @default.
• W2912182643 cites W2100791391 @default.
• W2912182643 cites W2113122028 @default.
• W2912182643 cites W2117942958 @default.
• W2912182643 cites W2126817554 @default.
• W2912182643 cites W2126872685 @default.
• W2912182643 cites W2133865472 @default.
• W2912182643 cites W2139008103 @default.
• W2912182643 cites W2141570482 @default.
• W2912182643 cites W2145122945 @default.
• W2912182643 cites W2147013683 @default.
• W2912182643 cites W2147387301 @default.
• W2912182643 cites W2159466690 @default.
• W2912182643 cites W2160382843 @default.
• W2912182643 cites W2168784615 @default.
• W2912182643 cites W2192402461 @default.
• W2912182643 cites W2296545900 @default.
• W2912182643 cites W2338964372 @default.
• W2912182643 cites W2366536035 @default.
• W2912182643 cites W2386703324 @default.
• W2912182643 cites W2460918282 @default.
• W2912182643 cites W2475161005 @default.
• W2912182643 cites W2505666614 @default.
• W2912182643 cites W2527733398 @default.
• W2912182643 cites W2593536471 @default.
• W2912182643 cites W2659205250 @default.
• W2912182643 cites W2740535722 @default.
• W2912182643 cites W2744160381 @default.
• W2912182643 cites W2753965703 @default.
• W2912182643 cites W4244944704 @default.
• W2912182643 cites W571060166 @default.
• W2912182643 cites W80380620 @default.
• W2912182643 doi "https://doi.org/10.1111/1754-9485.12850" @default.
• W2912182643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30677248" @default.
• W2912182643 hasPublicationYear "2019" @default.
• W2912182643 type Work @default.
• W2912182643 sameAs 2912182643 @default.
• W2912182643 citedByCount "6" @default.
• W2912182643 countsByYear W29121826432019 @default.
• W2912182643 countsByYear W29121826432020 @default.
• W2912182643 countsByYear W29121826432021 @default.
• W2912182643 countsByYear W29121826432022 @default.
• W2912182643 crossrefType "journal-article" @default.
• W2912182643 hasAuthorship W2912182643A5004781307 @default.
• W2912182643 hasAuthorship W2912182643A5009478113 @default.
• W2912182643 hasAuthorship W2912182643A5056401056 @default.
• W2912182643 hasAuthorship W2912182643A5056408183 @default.
• W2912182643 hasAuthorship W2912182643A5057619248 @default.
• W2912182643 hasAuthorship W2912182643A5061869022 @default.
• W2912182643 hasAuthorship W2912182643A5063111253 @default.
• W2912182643 hasAuthorship W2912182643A5064296968 @default.
• W2912182643 hasAuthorship W2912182643A5066896961 @default.
• W2912182643 hasAuthorship W2912182643A5078281474 @default.
• W2912182643 hasAuthorship W2912182643A5083131273 @default.
• W2912182643 hasAuthorship W2912182643A5085797205 @default.
• W2912182643 hasAuthorship W2912182643A5091740838 @default.
• W2912182643 hasConcept C104317684 @default.
• W2912182643 hasConcept C10515644 @default.
• W2912182643 hasConcept C126322002 @default.
• W2912182643 hasConcept C127848430 @default.
• W2912182643 hasConcept C143998085 @default.
• W2912182643 hasConcept C181199279 @default.
• W2912182643 hasConcept C185592680 @default.
• W2912182643 hasConcept C188816634 @default.
• W2912182643 hasConcept C2776694085 @default.
• W2912182643 hasConcept C2777150147 @default.
• W2912182643 hasConcept C2777389519 @default.
• W2912182643 hasConcept C2777931997 @default.
• W2912182643 hasConcept C2778227246 @default.
• W2912182643 hasConcept C2778880634 @default.
• W2912182643 hasConcept C2779083369 @default.
• W2912182643 hasConcept C501734568 @default.

• next