FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912183986> ?p ?o ?g. }

• W2912183986 endingPage "251513551882162" @default.
• W2912183986 startingPage "251513551882162" @default.
• W2912183986 abstract "Cancer stem cells (CSCs) can act as the cellular drivers of tumors harnessing stem cell properties that contribute to tumorigenesis either as founder elements or by the gain of stem cell traits by the malignant cells. Thus, CSCs can self-renew and generate the cellular heterogeneity of tumors including a hierarchical organization similar to the normal tissue. While the principle tumor growth contribution is often from the non-CSC components, it is the ability of small numbers of CSCs to avoid the effects of therapeutic strategies that can contribute to recurrence after treatment. However, identifying and characterizing CSCs for therapeutic targeting is made more challenging by their cellular potency being influenced by a particular tissue niche or by the capacity of more committed cells to regain stem cell functions. This review discusses the properties of CSCs including the limitations of the available cell surface markers, the assays that document tumor initiation and clonogenicity, the roles of epithelial mesenchymal transition and molecular pathways such as Notch, Wnt, Hippo and Hedgehog. The ability to target and eliminate CSCs is thought to be critical in the search for curative cancer treatments. The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. There are several different immunotherapies targeting 5T4 in development including antibody–drug conjugates, antibody-targeted bacterial super-antigens, a Modified Vaccinia Ankara-basedvaccine and 5T4-directed chimeric antigen receptor T-cells. These immune therapies would have the advantage of targeting both the bulk tumor as well as mobilized CSC populations." @default.
• W2912183986 created "2019-02-21" @default.
• W2912183986 creator A5019032517 @default.
• W2912183986 creator A5048742778 @default.
• W2912183986 creator A5082997520 @default.
• W2912183986 date "2019-01-01" @default.
• W2912183986 modified "2023-09-25" @default.
• W2912183986 title "Cancer stem cell mobilization and therapeutic targeting of the 5T4 oncofetal antigen" @default.
• W2912183986 cites W1483167997 @default.
• W2912183986 cites W148443711 @default.
• W2912183986 cites W1582760249 @default.
• W2912183986 cites W1586742424 @default.
• W2912183986 cites W1603787733 @default.
• W2912183986 cites W1966828612 @default.
• W2912183986 cites W1966956399 @default.
• W2912183986 cites W1971402898 @default.
• W2912183986 cites W1974655218 @default.
• W2912183986 cites W1974688346 @default.
• W2912183986 cites W1976324983 @default.
• W2912183986 cites W1976823472 @default.
• W2912183986 cites W1979440527 @default.
• W2912183986 cites W1982202983 @default.
• W2912183986 cites W1982603620 @default.
• W2912183986 cites W1992676863 @default.
• W2912183986 cites W1995077721 @default.
• W2912183986 cites W2001744598 @default.
• W2912183986 cites W2003371452 @default.
• W2912183986 cites W2004405095 @default.
• W2912183986 cites W2008011940 @default.
• W2912183986 cites W2008271309 @default.
• W2912183986 cites W2010867675 @default.
• W2912183986 cites W2011202983 @default.
• W2912183986 cites W2012247886 @default.
• W2912183986 cites W2016833582 @default.
• W2912183986 cites W2020969391 @default.
• W2912183986 cites W2023427658 @default.
• W2912183986 cites W2023624246 @default.
• W2912183986 cites W2028030685 @default.
• W2912183986 cites W2030967994 @default.
• W2912183986 cites W2033077654 @default.
• W2912183986 cites W2034712485 @default.
• W2912183986 cites W2035151737 @default.
• W2912183986 cites W2040430549 @default.
• W2912183986 cites W2046731610 @default.
• W2912183986 cites W2047845173 @default.
• W2912183986 cites W2050210037 @default.
• W2912183986 cites W2050300062 @default.
• W2912183986 cites W2051870121 @default.
• W2912183986 cites W2058569154 @default.
• W2912183986 cites W2060649255 @default.
• W2912183986 cites W2060880656 @default.
• W2912183986 cites W2061759855 @default.
• W2912183986 cites W2065946901 @default.
• W2912183986 cites W2069069106 @default.
• W2912183986 cites W2075994912 @default.
• W2912183986 cites W2079569124 @default.
• W2912183986 cites W2082128755 @default.
• W2912183986 cites W2082161467 @default.
• W2912183986 cites W2083373575 @default.
• W2912183986 cites W2087353516 @default.
• W2912183986 cites W2088922876 @default.
• W2912183986 cites W2089325681 @default.
• W2912183986 cites W2089361444 @default.
• W2912183986 cites W2091742850 @default.
• W2912183986 cites W2099149369 @default.
• W2912183986 cites W2101151845 @default.
• W2912183986 cites W2101279871 @default.
• W2912183986 cites W2104518333 @default.
• W2912183986 cites W2104998312 @default.
• W2912183986 cites W2108954643 @default.
• W2912183986 cites W2109792915 @default.
• W2912183986 cites W2112008630 @default.
• W2912183986 cites W2113415488 @default.
• W2912183986 cites W2114496204 @default.
• W2912183986 cites W2116018770 @default.
• W2912183986 cites W2119770631 @default.
• W2912183986 cites W2124462445 @default.
• W2912183986 cites W2133117291 @default.
• W2912183986 cites W2135190835 @default.
• W2912183986 cites W2144377468 @default.
• W2912183986 cites W2146812359 @default.
• W2912183986 cites W2151011478 @default.
• W2912183986 cites W2153101406 @default.
• W2912183986 cites W2156121496 @default.
• W2912183986 cites W2158687576 @default.
• W2912183986 cites W2166366659 @default.
• W2912183986 cites W2170056895 @default.
• W2912183986 cites W2170086508 @default.
• W2912183986 cites W2171581347 @default.
• W2912183986 cites W2195589504 @default.
• W2912183986 cites W2206188231 @default.
• W2912183986 cites W2227211170 @default.
• W2912183986 cites W2276370059 @default.
• W2912183986 cites W2303309927 @default.
• W2912183986 cites W2338910578 @default.
• W2912183986 cites W2409811112 @default.
• W2912183986 cites W2413458835 @default.
• W2912183986 cites W2482875018 @default.

• next