Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912184892> ?p ?o ?g. }
- W2912184892 endingPage "944" @default.
- W2912184892 startingPage "935" @default.
- W2912184892 abstract "Abstract Islet transplantation has the potential to cure type 1 diabetes, but current transplantation protocols are not optimal and there is extensive loss of islet β-cell insulin secretory function during the immediate post-transplantation period. Studies using experimental models of diabetes have shown that the coculture of islets with mesenchymal stromal cells (MSCs) prior to transplantation improves graft function, but several variables differed among research groups (e.g., type of MSCs used and the treatment conditions). We have therefore assessed the effects of MSCs on mouse and human islets by investigating the importance of tissue source for MSCs, the coculture protocol configuration and length, the effect of activated MSCs, and different β-cell secretory stimuli. MSCs derived from adipose tissue (aMSCs) were the most effective at supporting β-cell insulin secretion in both mouse and human islets, in a direct contact coculture configuration. Preculture with aMSCs enhanced both phases of glucose-induced insulin secretion and further enhanced secretory responses to the non-nutrients carbachol and arginine. These effects required a coculture period of 48–72 hours and were not dependent on activation of the MSCs. Thus, direct contact coculture with autologous, adipose-derived MSCs for a minimum of 48 hours before implantation is likely to be an effective addition to human islet transplantation protocols. Stem Cells Translational Medicine 2019;8:935–944" @default.
- W2912184892 created "2019-02-21" @default.
- W2912184892 creator A5002229329 @default.
- W2912184892 creator A5044799417 @default.
- W2912184892 creator A5051016007 @default.
- W2912184892 creator A5052351245 @default.
- W2912184892 creator A5054447877 @default.
- W2912184892 creator A5074213087 @default.
- W2912184892 creator A5081961964 @default.
- W2912184892 creator A5085508421 @default.
- W2912184892 date "2019-05-08" @default.
- W2912184892 modified "2023-09-25" @default.
- W2912184892 title "Characterization of the Effects of Mesenchymal Stromal Cells on Mouse and Human Islet Function" @default.
- W2912184892 cites W1510928501 @default.
- W2912184892 cites W1567911976 @default.
- W2912184892 cites W1752100137 @default.
- W2912184892 cites W181566666 @default.
- W2912184892 cites W1979758071 @default.
- W2912184892 cites W1985117435 @default.
- W2912184892 cites W1999010820 @default.
- W2912184892 cites W2009294659 @default.
- W2912184892 cites W2010407096 @default.
- W2912184892 cites W2013840177 @default.
- W2912184892 cites W2021961757 @default.
- W2912184892 cites W2024326908 @default.
- W2912184892 cites W2025353471 @default.
- W2912184892 cites W2030709554 @default.
- W2912184892 cites W2045080708 @default.
- W2912184892 cites W2045433259 @default.
- W2912184892 cites W2045696456 @default.
- W2912184892 cites W2052689814 @default.
- W2912184892 cites W2054989525 @default.
- W2912184892 cites W2058102240 @default.
- W2912184892 cites W2067057684 @default.
- W2912184892 cites W2071103940 @default.
- W2912184892 cites W2083071292 @default.
- W2912184892 cites W2092702917 @default.
- W2912184892 cites W2093300538 @default.
- W2912184892 cites W2095189993 @default.
- W2912184892 cites W2131755176 @default.
- W2912184892 cites W2153700672 @default.
- W2912184892 cites W2160392015 @default.
- W2912184892 cites W2162512339 @default.
- W2912184892 cites W2178014057 @default.
- W2912184892 cites W2272666867 @default.
- W2912184892 cites W2327267066 @default.
- W2912184892 cites W2408443895 @default.
- W2912184892 cites W2408666797 @default.
- W2912184892 cites W2512345434 @default.
- W2912184892 cites W2554650020 @default.
- W2912184892 cites W2573535579 @default.
- W2912184892 cites W2584462774 @default.
- W2912184892 cites W2593391971 @default.
- W2912184892 cites W2767097809 @default.
- W2912184892 cites W2792380005 @default.
- W2912184892 cites W2802034175 @default.
- W2912184892 cites W2886539858 @default.
- W2912184892 cites W2898382095 @default.
- W2912184892 doi "https://doi.org/10.1002/sctm.19-0023" @default.
- W2912184892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6708063" @default.
- W2912184892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31066521" @default.
- W2912184892 hasPublicationYear "2019" @default.
- W2912184892 type Work @default.
- W2912184892 sameAs 2912184892 @default.
- W2912184892 citedByCount "15" @default.
- W2912184892 countsByYear W29121848922020 @default.
- W2912184892 countsByYear W29121848922021 @default.
- W2912184892 countsByYear W29121848922022 @default.
- W2912184892 countsByYear W29121848922023 @default.
- W2912184892 crossrefType "journal-article" @default.
- W2912184892 hasAuthorship W2912184892A5002229329 @default.
- W2912184892 hasAuthorship W2912184892A5044799417 @default.
- W2912184892 hasAuthorship W2912184892A5051016007 @default.
- W2912184892 hasAuthorship W2912184892A5052351245 @default.
- W2912184892 hasAuthorship W2912184892A5054447877 @default.
- W2912184892 hasAuthorship W2912184892A5074213087 @default.
- W2912184892 hasAuthorship W2912184892A5081961964 @default.
- W2912184892 hasAuthorship W2912184892A5085508421 @default.
- W2912184892 hasBestOaLocation W29121848921 @default.
- W2912184892 hasConcept C10882517 @default.
- W2912184892 hasConcept C126322002 @default.
- W2912184892 hasConcept C134018914 @default.
- W2912184892 hasConcept C165220095 @default.
- W2912184892 hasConcept C16930146 @default.
- W2912184892 hasConcept C171089720 @default.
- W2912184892 hasConcept C198826908 @default.
- W2912184892 hasConcept C2779306644 @default.
- W2912184892 hasConcept C2781232474 @default.
- W2912184892 hasConcept C28328180 @default.
- W2912184892 hasConcept C2911091166 @default.
- W2912184892 hasConcept C502942594 @default.
- W2912184892 hasConcept C555293320 @default.
- W2912184892 hasConcept C71924100 @default.
- W2912184892 hasConcept C86803240 @default.
- W2912184892 hasConcept C95444343 @default.
- W2912184892 hasConceptScore W2912184892C10882517 @default.
- W2912184892 hasConceptScore W2912184892C126322002 @default.
- W2912184892 hasConceptScore W2912184892C134018914 @default.