FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912185426> ?p ?o ?g. }

• W2912185426 abstract "People with nonrheumatic atrial fibrillation (NRAF) who have had a transient ischemic attack (TIA) or minor ischemic stroke are at risk of recurrent stroke. Both warfarin and aspirin have been shown to reduce the recurrence of vascular events.The objective of this review was to compare the effect of anticoagulants with antiplatelet agents, for secondary prevention, in people with NRAF and previous cerebral ischemia.We searched the Cochrane Stroke Group trials register (last searched 9 June 2003) and contacted trialists.Randomised trials comparing oral anticoagulants with antiplatelet agents in patients with NRAF and a previous TIA or minor ischemic stroke.Both reviewers extracted and analysed data.Two trial were identified. The European Atrial Fibrillation Trial (EAFT) involving 455 patients, who received either anticoagulants (International Normalised Ratio (INR) 2.5 to 4.0), or aspirin (300 mg/day). Patients joined the trial within three months of transient ischemic attack or minor stroke. The mean follow up was 2.3 years. In the Studio Italiano Fibrillazione Atriale (SIFA) trial, 916 patients with NRAF and a TIA or minor stroke within the previous 15 days were randomised to open label anticoagulants (INR 2.0 to 3.5) or indobufen (a reversible platelet cyclooxygenase inhibitor, 100 or 200 mg BID). The follow-up period was one year. The combined results show that anticoagulants were significantly more effective than antiplatelet therapy both for all vascular events (Peto odds ratio (Peto OR) 0.67, 95% confidence interval (CI) 0.50 to 0.91) and for recurrent stroke (Peto OR 0.49, 95% CI 0.33 to 0.72). Major extracranial bleeding complications occurred more often in patients on anticoagulants (Peto OR 5.16, 95% CI 2.08 to 12.83), but the absolute difference was small (2.8% per year versus 0.9% per year in EAFT and 0.9% per year versus 0% in SIFA). Warfarin did not cause a significant increase of intracranial bleeds.The evidence from two trials suggests that anticoagulant therapy is superior to antiplatelet therapy for the prevention of stroke in people with NRAF and recent non-disabling stroke or TIA. The risk of extracranial bleeding was higher with anticoagulant therapy than with antiplatelet therapy." @default.
• W2912185426 created "2019-02-21" @default.
• W2912185426 creator A5021283016 @default.
• W2912185426 creator A5063851108 @default.
• W2912185426 date "2004-10-18" @default.
• W2912185426 modified "2023-09-25" @default.
• W2912185426 title "Anticoagulants versus antiplatelet therapy for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischemic attack" @default.
• W2912185426 cites W1809125732 @default.
• W2912185426 cites W2014148243 @default.
• W2912185426 cites W2021265694 @default.
• W2912185426 cites W2021373460 @default.
• W2912185426 cites W2029345778 @default.
• W2912185426 cites W2031664609 @default.
• W2912185426 cites W2040452288 @default.
• W2912185426 cites W2041723578 @default.
• W2912185426 cites W2044891648 @default.
• W2912185426 cites W2045913143 @default.
• W2912185426 cites W2060630424 @default.
• W2912185426 cites W2070750514 @default.
• W2912185426 cites W2076969828 @default.
• W2912185426 cites W2087828360 @default.
• W2912185426 cites W2097730817 @default.
• W2912185426 cites W2110392825 @default.
• W2912185426 cites W2114775432 @default.
• W2912185426 cites W2127211051 @default.
• W2912185426 cites W2435343268 @default.
• W2912185426 cites W2465663631 @default.
• W2912185426 cites W2499224120 @default.
• W2912185426 cites W4229847571 @default.
• W2912185426 cites W4245119661 @default.
• W2912185426 cites W4245449645 @default.
• W2912185426 cites W4247088564 @default.
• W2912185426 cites W4362054082 @default.
• W2912185426 cites W4366111159 @default.
• W2912185426 cites W44202489 @default.
• W2912185426 doi "https://doi.org/10.1002/14651858.cd000187.pub2" @default.
• W2912185426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15494992" @default.
• W2912185426 hasPublicationYear "2004" @default.
• W2912185426 type Work @default.
• W2912185426 sameAs 2912185426 @default.
• W2912185426 citedByCount "70" @default.
• W2912185426 countsByYear W29121854262012 @default.
• W2912185426 countsByYear W29121854262013 @default.
• W2912185426 countsByYear W29121854262014 @default.
• W2912185426 countsByYear W29121854262015 @default.
• W2912185426 countsByYear W29121854262016 @default.
• W2912185426 countsByYear W29121854262017 @default.
• W2912185426 countsByYear W29121854262018 @default.
• W2912185426 countsByYear W29121854262019 @default.
• W2912185426 countsByYear W29121854262020 @default.
• W2912185426 countsByYear W29121854262021 @default.
• W2912185426 countsByYear W29121854262023 @default.
• W2912185426 crossrefType "journal-article" @default.
• W2912185426 hasAuthorship W2912185426A5021283016 @default.
• W2912185426 hasAuthorship W2912185426A5063851108 @default.
• W2912185426 hasConcept C126322002 @default.
• W2912185426 hasConcept C127413603 @default.
• W2912185426 hasConcept C156957248 @default.
• W2912185426 hasConcept C164705383 @default.
• W2912185426 hasConcept C2776301958 @default.
• W2912185426 hasConcept C2777628954 @default.
• W2912185426 hasConcept C2779161974 @default.
• W2912185426 hasConcept C2780645631 @default.
• W2912185426 hasConcept C2909112448 @default.
• W2912185426 hasConcept C71924100 @default.
• W2912185426 hasConcept C78519656 @default.
• W2912185426 hasConceptScore W2912185426C126322002 @default.
• W2912185426 hasConceptScore W2912185426C127413603 @default.
• W2912185426 hasConceptScore W2912185426C156957248 @default.
• W2912185426 hasConceptScore W2912185426C164705383 @default.
• W2912185426 hasConceptScore W2912185426C2776301958 @default.
• W2912185426 hasConceptScore W2912185426C2777628954 @default.
• W2912185426 hasConceptScore W2912185426C2779161974 @default.
• W2912185426 hasConceptScore W2912185426C2780645631 @default.
• W2912185426 hasConceptScore W2912185426C2909112448 @default.
• W2912185426 hasConceptScore W2912185426C71924100 @default.
• W2912185426 hasConceptScore W2912185426C78519656 @default.
• W2912185426 hasLocation W29121854261 @default.
• W2912185426 hasLocation W29121854262 @default.
• W2912185426 hasOpenAccess W2912185426 @default.
• W2912185426 hasPrimaryLocation W29121854261 @default.
• W2912185426 hasRelatedWork W2006713942 @default.
• W2912185426 hasRelatedWork W2114223015 @default.
• W2912185426 hasRelatedWork W2115859112 @default.
• W2912185426 hasRelatedWork W2241853559 @default.
• W2912185426 hasRelatedWork W2351809860 @default.
• W2912185426 hasRelatedWork W2369167285 @default.
• W2912185426 hasRelatedWork W2415605004 @default.
• W2912185426 hasRelatedWork W2945399567 @default.
• W2912185426 hasRelatedWork W3029269458 @default.
• W2912185426 hasRelatedWork W3031140333 @default.
• W2912185426 isParatext "false" @default.
• W2912185426 isRetracted "false" @default.
• W2912185426 magId "2912185426" @default.
• W2912185426 workType "article" @default.