FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912186852> ?p ?o ?g. }

• W2912186852 endingPage "14" @default.
• W2912186852 startingPage "6" @default.
• W2912186852 abstract "Leishmaniasis is one of the most significant of the neglected tropical diseases, with 350 million people in 98 countries worldwide living at risk of developing one of the many forms of the disease. During the transmission of the parasite from its vector to the vertebrate host, neutrophils are rapidly recruited to the site of the sandfly bite. Using different strategies, neutrophils can often kill a large number of parasites. However, some parasites can resist neutrophil-killing mechanisms and survive until macrophage arrival at the infection site. One of the strategies for neutrophil-mediated killing is the production of neutrophil extracellular traps (NETs). Because of its ecto-localized nuclease activity, the enzyme 3’-nucleotidase/nuclease (3’NT/NU), present in different Leishmania species, was recently identified as part of a possible parasite escape mechanism from NET-mediated death. Previous studies showed that 3’NT/NU also plays an important role in the establishment of Leishmania infection by generating extracellular adenosine that favors the parasite and macrophage interaction. This study aims to deepen the knowledge about 3’NT/NU, mainly with respect to its nuclease activity that is little studied in the current literature. For this, we cloned, expressed and purified the recombinant La3'NT/NU and have confirmed its contribution to the parasite escape from NET-mediated killing." @default.
• W2912186852 created "2019-02-21" @default.
• W2912186852 creator A5012276729 @default.
• W2912186852 creator A5014714379 @default.
• W2912186852 creator A5030247415 @default.
• W2912186852 creator A5077423516 @default.
• W2912186852 creator A5087596827 @default.
• W2912186852 creator A5089041396 @default.
• W2912186852 creator A5089386600 @default.
• W2912186852 date "2019-04-01" @default.
• W2912186852 modified "2023-10-16" @default.
• W2912186852 title "Cloning, expression and purification of 3'-nucleotidase/nuclease, an enzyme responsible for the Leishmania escape from neutrophil extracellular traps" @default.
• W2912186852 cites W1566515137 @default.
• W2912186852 cites W1675724274 @default.
• W2912186852 cites W1966208653 @default.
• W2912186852 cites W1974713321 @default.
• W2912186852 cites W2000845481 @default.
• W2912186852 cites W2005006968 @default.
• W2912186852 cites W2009232246 @default.
• W2912186852 cites W2011770900 @default.
• W2912186852 cites W2012742309 @default.
• W2912186852 cites W2018893159 @default.
• W2912186852 cites W2025727064 @default.
• W2912186852 cites W2048393300 @default.
• W2912186852 cites W2055284277 @default.
• W2912186852 cites W2056637829 @default.
• W2912186852 cites W2057601877 @default.
• W2912186852 cites W2063966020 @default.
• W2912186852 cites W2078216090 @default.
• W2912186852 cites W2084434937 @default.
• W2912186852 cites W2088010709 @default.
• W2912186852 cites W2091942638 @default.
• W2912186852 cites W2092168714 @default.
• W2912186852 cites W2094578161 @default.
• W2912186852 cites W2100837269 @default.
• W2912186852 cites W2104934425 @default.
• W2912186852 cites W2107277218 @default.
• W2912186852 cites W2118925320 @default.
• W2912186852 cites W2136115564 @default.
• W2912186852 cites W2137937899 @default.
• W2912186852 cites W2141583772 @default.
• W2912186852 cites W2142853840 @default.
• W2912186852 cites W2153435210 @default.
• W2912186852 cites W2154819732 @default.
• W2912186852 cites W2396196291 @default.
• W2912186852 cites W2517702283 @default.
• W2912186852 cites W2621319584 @default.
• W2912186852 cites W2758927599 @default.
• W2912186852 cites W2769644758 @default.
• W2912186852 cites W2790858288 @default.
• W2912186852 cites W28756939 @default.
• W2912186852 cites W4293247451 @default.
• W2912186852 doi "https://doi.org/10.1016/j.molbiopara.2019.02.004" @default.
• W2912186852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30772424" @default.
• W2912186852 hasPublicationYear "2019" @default.
• W2912186852 type Work @default.
• W2912186852 sameAs 2912186852 @default.
• W2912186852 citedByCount "9" @default.
• W2912186852 countsByYear W29121868522020 @default.
• W2912186852 countsByYear W29121868522021 @default.
• W2912186852 countsByYear W29121868522022 @default.
• W2912186852 countsByYear W29121868522023 @default.
• W2912186852 crossrefType "journal-article" @default.
• W2912186852 hasAuthorship W2912186852A5012276729 @default.
• W2912186852 hasAuthorship W2912186852A5014714379 @default.
• W2912186852 hasAuthorship W2912186852A5030247415 @default.
• W2912186852 hasAuthorship W2912186852A5077423516 @default.
• W2912186852 hasAuthorship W2912186852A5087596827 @default.
• W2912186852 hasAuthorship W2912186852A5089041396 @default.
• W2912186852 hasAuthorship W2912186852A5089386600 @default.
• W2912186852 hasConcept C134897094 @default.
• W2912186852 hasConcept C136764020 @default.
• W2912186852 hasConcept C159047783 @default.
• W2912186852 hasConcept C181199279 @default.
• W2912186852 hasConcept C203014093 @default.
• W2912186852 hasConcept C2776914184 @default.
• W2912186852 hasConcept C2777271071 @default.
• W2912186852 hasConcept C2777913276 @default.
• W2912186852 hasConcept C2781092759 @default.
• W2912186852 hasConcept C28406088 @default.
• W2912186852 hasConcept C41008148 @default.
• W2912186852 hasConcept C55493867 @default.
• W2912186852 hasConcept C71928629 @default.
• W2912186852 hasConcept C86803240 @default.
• W2912186852 hasConcept C89423630 @default.
• W2912186852 hasConcept C95444343 @default.
• W2912186852 hasConceptScore W2912186852C134897094 @default.
• W2912186852 hasConceptScore W2912186852C136764020 @default.
• W2912186852 hasConceptScore W2912186852C159047783 @default.
• W2912186852 hasConceptScore W2912186852C181199279 @default.
• W2912186852 hasConceptScore W2912186852C203014093 @default.
• W2912186852 hasConceptScore W2912186852C2776914184 @default.
• W2912186852 hasConceptScore W2912186852C2777271071 @default.
• W2912186852 hasConceptScore W2912186852C2777913276 @default.
• W2912186852 hasConceptScore W2912186852C2781092759 @default.
• W2912186852 hasConceptScore W2912186852C28406088 @default.
• W2912186852 hasConceptScore W2912186852C41008148 @default.
• W2912186852 hasConceptScore W2912186852C55493867 @default.

• next