FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912187440> ?p ?o ?g. }

• W2912187440 abstract "The development of new capillary networks in engineered constructs is essential for their survival and their integration with the host tissue. It has recently been demonstrated that ELR-based hydrogels encoding different bioactivities are able to modulate their interaction with the host after injection or implantation, as indicated by an increase in cell adhesion and the ability to trigger vascularization processes. Accordingly, the aim of this study was to increase their angiogenic ability both in vitro and in vivo using a small VEGF mimetic peptide named QK, which was tethered chemically to ELR-based hydrogels containing cell-adhesion sequences in their backbone, such as REDV and RGD, as well as a proteolytic site (VGVAPG). In vitro studies were performed using a co-culture of endothelial and fibroblast cells encapsulated into the ELR-based hydrogels in order to determine cell proliferation after 21 days of culture, as well as the number of cell-cell interactions. It was found that although the presence of this peptide does not influence the morphological and rheological properties of these hydrogels, it has an effect on cell behaviour, inducing an increase in cell proliferation and the formation of endothelial cell clusters. In vivo studies demonstrate that the QK peptide enhances the formation of prominent functional capillaries at three weeks post-injection, as confirmed by H&E staining and CD31 immunohistochemistry. The newly formed functional microvasculature ensures perfusion and connection with surrounding tissues. These results show that ELR-QK hydrogels increase capillary network formation and are therefore attractive candidates for application in tissue regeneration, for example for the treatment of cardiovascular diseases such as myocardial infarction or ischemia." @default.
• W2912187440 created "2019-02-21" @default.
• W2912187440 creator A5002114721 @default.
• W2912187440 creator A5025058277 @default.
• W2912187440 creator A5034426319 @default.
• W2912187440 creator A5034827964 @default.
• W2912187440 date "2019-02-01" @default.
• W2912187440 modified "2023-09-28" @default.
• W2912187440 title "Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels" @default.
• W2912187440 cites W1565304586 @default.
• W2912187440 cites W1600721209 @default.
• W2912187440 cites W1966703456 @default.
• W2912187440 cites W1967589959 @default.
• W2912187440 cites W1967934018 @default.
• W2912187440 cites W1969215799 @default.
• W2912187440 cites W1970147513 @default.
• W2912187440 cites W1972269986 @default.
• W2912187440 cites W1976779973 @default.
• W2912187440 cites W1978577250 @default.
• W2912187440 cites W1989477788 @default.
• W2912187440 cites W1992122289 @default.
• W2912187440 cites W200732135 @default.
• W2912187440 cites W2007335169 @default.
• W2912187440 cites W2011493149 @default.
• W2912187440 cites W2021524638 @default.
• W2912187440 cites W2027220430 @default.
• W2912187440 cites W2039982056 @default.
• W2912187440 cites W2042706188 @default.
• W2912187440 cites W2063819883 @default.
• W2912187440 cites W2067037209 @default.
• W2912187440 cites W2081510823 @default.
• W2912187440 cites W2084029306 @default.
• W2912187440 cites W2084538405 @default.
• W2912187440 cites W2084659355 @default.
• W2912187440 cites W2089954496 @default.
• W2912187440 cites W2092662468 @default.
• W2912187440 cites W2097028187 @default.
• W2912187440 cites W2101274991 @default.
• W2912187440 cites W2111037525 @default.
• W2912187440 cites W2114286636 @default.
• W2912187440 cites W2117590742 @default.
• W2912187440 cites W2126956733 @default.
• W2912187440 cites W2129358933 @default.
• W2912187440 cites W2135705032 @default.
• W2912187440 cites W2136954306 @default.
• W2912187440 cites W2139519727 @default.
• W2912187440 cites W2163321666 @default.
• W2912187440 cites W2163660141 @default.
• W2912187440 cites W2168056522 @default.
• W2912187440 cites W2169772833 @default.
• W2912187440 cites W2514059345 @default.
• W2912187440 cites W2531963904 @default.
• W2912187440 cites W2609493101 @default.
• W2912187440 cites W2752163611 @default.
• W2912187440 cites W2766965864 @default.
• W2912187440 cites W2792268491 @default.
• W2912187440 doi "https://doi.org/10.1007/s10856-019-6232-z" @default.
• W2912187440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30762134" @default.
• W2912187440 hasPublicationYear "2019" @default.
• W2912187440 type Work @default.
• W2912187440 sameAs 2912187440 @default.
• W2912187440 citedByCount "38" @default.
• W2912187440 countsByYear W29121874402019 @default.
• W2912187440 countsByYear W29121874402020 @default.
• W2912187440 countsByYear W29121874402021 @default.
• W2912187440 countsByYear W29121874402022 @default.
• W2912187440 countsByYear W29121874402023 @default.
• W2912187440 crossrefType "journal-article" @default.
• W2912187440 hasAuthorship W2912187440A5002114721 @default.
• W2912187440 hasAuthorship W2912187440A5025058277 @default.
• W2912187440 hasAuthorship W2912187440A5034426319 @default.
• W2912187440 hasAuthorship W2912187440A5034827964 @default.
• W2912187440 hasBestOaLocation W29121874402 @default.
• W2912187440 hasConcept C108586683 @default.
• W2912187440 hasConcept C123012128 @default.
• W2912187440 hasConcept C12554922 @default.
• W2912187440 hasConcept C1491633281 @default.
• W2912187440 hasConcept C150903083 @default.
• W2912187440 hasConcept C178790620 @default.
• W2912187440 hasConcept C185592680 @default.
• W2912187440 hasConcept C188027245 @default.
• W2912187440 hasConcept C202751555 @default.
• W2912187440 hasConcept C207001950 @default.
• W2912187440 hasConcept C2778939058 @default.
• W2912187440 hasConcept C2779281246 @default.
• W2912187440 hasConcept C2779869378 @default.
• W2912187440 hasConcept C2780381497 @default.
• W2912187440 hasConcept C2780394083 @default.
• W2912187440 hasConcept C502942594 @default.
• W2912187440 hasConcept C54355233 @default.
• W2912187440 hasConcept C55493867 @default.
• W2912187440 hasConcept C84416704 @default.
• W2912187440 hasConcept C85789140 @default.
• W2912187440 hasConcept C86803240 @default.
• W2912187440 hasConcept C95444343 @default.
• W2912187440 hasConceptScore W2912187440C108586683 @default.
• W2912187440 hasConceptScore W2912187440C123012128 @default.
• W2912187440 hasConceptScore W2912187440C12554922 @default.
• W2912187440 hasConceptScore W2912187440C1491633281 @default.
• W2912187440 hasConceptScore W2912187440C150903083 @default.

• next