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- W2912187592 abstract "Allergic Rhinitis (AR) is linked to early-life allergen sensitization. Patterns of sensitization may confer differential risk for AR. We assessed whether the risk of childhood AR differed depending upon allergen sensitization profiles at age 2-3 years. Allergen sensitization to seven inhalant and three food allergens were assessed by specific IgE at age 2-3 years among participants in the Detroit-area WHEALS birth cohort. Positive tests were defined by specific IgE≥0.35 IU/ml. Four previously identified sensitization patterns at age 2-3 were also examined: low/no sensitization (LS); highly multiply-sensitized (HS); milk/egg dominated sensitization (MES) and peanut/inhalant sensitization (PIS). Current AR was determined by physician evaluation during a study-related visit at age 10-12 years. Relative risks (RR) for AR were calculated for the sensitization frequency and pattern categories determined at age 2-3 years. Compared to 185 non-sensitized children, the risk of AR was not statistically significantly higher for the 69 children with one positive test (RR=1.19, 95% CI=0.94,1.50; p=0.16) but higher for the 91 children with ≥2 positive tests (RR=1.46, 95% CI=1.21,1.75; p<0.001). Compared to 259 LS children, the risk of AR was greater (RR=1.68,95% CI=1.39, 2.04; p<0.001) for the 13 HS children, the 54 MES children (RR=1.25, 95% CI=1.01, 1.55; p=0.039), and the 19 PIS children (RR=1.34, 95% CI=1.01, 1.80; p=0.046). Children with multiple (≥2) positive IgE tests at age 2-3 years were at higher risk for AR in the preteen years. Multi-sensitization as opposed to mono-sensitization may be a marker for allergic predisposition." @default.
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- W2912187592 date "2019-02-01" @default.
- W2912187592 modified "2023-09-27" @default.
- W2912187592 title "Early Life Sensitization Patterns and Risk for Allergic Rhinitis in the WHEALS Birth Cohort" @default.
- W2912187592 doi "https://doi.org/10.1016/j.jaci.2018.12.605" @default.
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