FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912187694> ?p ?o ?g. }

• W2912187694 endingPage "156" @default.
• W2912187694 startingPage "147" @default.
• W2912187694 abstract "Drosophila segmentation is regulated by a complex network of transcription factors that include products of the pair-rule genes (PRGs). PRGs are expressed in early embryos in the primorida of alternate segmental units, establishing the repeated, segmental body plan of the fly. Despite detailed analysis of the regulatory logic among segmentation genes, the relationship between these genes and the morphological formation of segments is still poorly understood, since regulation of transcription factor expression is not sufficient to explain how segments actually form and are maintained. Cell surface proteins containing Leucine rich repeats (LRR) play a variety of roles in development, and those expressed in segmental patterns likely impact segment morphogenesis. Here we explore the relationships between the PRG network and segmentally expressed LRR-encoding (sLRR) genes. We examined expression of Toll2, Toll6, Toll7, Toll8 and tartan (trn) in wild type or PRG mutant embryos. Expression of each sLRR-encoding gene is dynamic, but each has a unique register along the anterior-posterior axis. The registers for different sLRRs are off-set from one another resulting in a continually changing set of overlapping expression patterns among the sLRR-encoding genes themselves and between the sLRR-encoding genes and the PRGs. Accordingly, each sLRR-encoding gene is regulated by a unique combination of PRGs. These findings suggest that one role of the PRG network is to promote segmentation by establishing a cell surface code: each row of cells in the two-segment-wide primordia expresses a unique combination of sLRRs, thereby translating regulatory information from the PRGs to direct segment morphogenesis." @default.
• W2912187694 created "2019-02-21" @default.
• W2912187694 creator A5018032427 @default.
• W2912187694 creator A5029330197 @default.
• W2912187694 creator A5035649427 @default.
• W2912187694 creator A5055540440 @default.
• W2912187694 creator A5074619908 @default.
• W2912187694 date "2019-03-01" @default.
• W2912187694 modified "2023-10-16" @default.
• W2912187694 title "Dynamic expression of Drosophila segmental cell surface-encoding genes and their pair-rule regulators" @default.
• W2912187694 cites W1496444476 @default.
• W2912187694 cites W1911312248 @default.
• W2912187694 cites W1934579905 @default.
• W2912187694 cites W1970759130 @default.
• W2912187694 cites W1972889806 @default.
• W2912187694 cites W1974937639 @default.
• W2912187694 cites W1981770438 @default.
• W2912187694 cites W1985207173 @default.
• W2912187694 cites W1993766073 @default.
• W2912187694 cites W2000572318 @default.
• W2912187694 cites W2003085958 @default.
• W2912187694 cites W2005415007 @default.
• W2912187694 cites W2007651085 @default.
• W2912187694 cites W2007857578 @default.
• W2912187694 cites W2011441482 @default.
• W2912187694 cites W2011811206 @default.
• W2912187694 cites W2014908429 @default.
• W2912187694 cites W2016378258 @default.
• W2912187694 cites W2020046465 @default.
• W2912187694 cites W2035545932 @default.
• W2912187694 cites W2036896195 @default.
• W2912187694 cites W2041791362 @default.
• W2912187694 cites W2048228486 @default.
• W2912187694 cites W2053320483 @default.
• W2912187694 cites W2060181845 @default.
• W2912187694 cites W2072293838 @default.
• W2912187694 cites W2077995348 @default.
• W2912187694 cites W2085866853 @default.
• W2912187694 cites W2090153088 @default.
• W2912187694 cites W2092846446 @default.
• W2912187694 cites W2103526067 @default.
• W2912187694 cites W2106598628 @default.
• W2912187694 cites W2109134145 @default.
• W2912187694 cites W2109313025 @default.
• W2912187694 cites W2111648532 @default.
• W2912187694 cites W2116055030 @default.
• W2912187694 cites W2119699304 @default.
• W2912187694 cites W2129443011 @default.
• W2912187694 cites W2137429721 @default.
• W2912187694 cites W2146145315 @default.
• W2912187694 cites W2152207030 @default.
• W2912187694 cites W2162371815 @default.
• W2912187694 cites W2166530779 @default.
• W2912187694 cites W2168696662 @default.
• W2912187694 cites W2170964688 @default.
• W2912187694 cites W2171557946 @default.
• W2912187694 cites W2184241489 @default.
• W2912187694 cites W2189480951 @default.
• W2912187694 cites W2207634084 @default.
• W2912187694 cites W2401667795 @default.
• W2912187694 cites W2488989538 @default.
• W2912187694 cites W2531045464 @default.
• W2912187694 cites W2953338821 @default.
• W2912187694 cites W2983328036 @default.
• W2912187694 cites W4063809 @default.
• W2912187694 cites W4252891035 @default.
• W2912187694 doi "https://doi.org/10.1016/j.ydbio.2019.01.015" @default.
• W2912187694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6492026" @default.
• W2912187694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30695684" @default.
• W2912187694 hasPublicationYear "2019" @default.
• W2912187694 type Work @default.
• W2912187694 sameAs 2912187694 @default.
• W2912187694 citedByCount "11" @default.
• W2912187694 countsByYear W29121876942019 @default.
• W2912187694 countsByYear W29121876942020 @default.
• W2912187694 countsByYear W29121876942021 @default.
• W2912187694 countsByYear W29121876942022 @default.
• W2912187694 countsByYear W29121876942023 @default.
• W2912187694 crossrefType "journal-article" @default.
• W2912187694 hasAuthorship W2912187694A5018032427 @default.
• W2912187694 hasAuthorship W2912187694A5029330197 @default.
• W2912187694 hasAuthorship W2912187694A5035649427 @default.
• W2912187694 hasAuthorship W2912187694A5055540440 @default.
• W2912187694 hasAuthorship W2912187694A5074619908 @default.
• W2912187694 hasBestOaLocation W29121876942 @default.
• W2912187694 hasConcept C104317684 @default.
• W2912187694 hasConcept C150194340 @default.
• W2912187694 hasConcept C154945302 @default.
• W2912187694 hasConcept C184750944 @default.
• W2912187694 hasConcept C184937244 @default.
• W2912187694 hasConcept C40692019 @default.
• W2912187694 hasConcept C41008148 @default.
• W2912187694 hasConcept C54355233 @default.
• W2912187694 hasConcept C70721500 @default.
• W2912187694 hasConcept C86339819 @default.
• W2912187694 hasConcept C86803240 @default.
• W2912187694 hasConcept C89600930 @default.
• W2912187694 hasConceptScore W2912187694C104317684 @default.

• next