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- W2912187868 abstract "Summary Recent studies have reported on the presence of bacterial RNA within or outside extracellular membrane vesicles, possibly as ribonucleoprotein complexes. Proteins that bind and stabilize bacterial RNAs in the extracellular environment have not been reported. Here, we show that the bacterial pathogen Listeria monocytogenes secretes a small RNA binding protein that we named Zea. We show that Zea binds and stabilizes a subset of L. monocytogenes RNAs causing their accumulation in the extracellular medium. Furthermore, Zea binds RIG-I, the vertebrate non-self-RNA innate immunity sensor and potentiates RIG-I-signaling leading to interferon β production. By performing in vivo infection, we finally show that Zea modulates L. monocytogenes virulence. Together, this study reveals that bacterial extracellular RNAs and RNA binding proteins can affect the host-pathogen crosstalk." @default.
- W2912187868 created "2019-02-21" @default.
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- W2912187868 date "2019-02-07" @default.
- W2912187868 modified "2023-10-18" @default.
- W2912187868 title "An RNA-binding protein secreted byListeria monocytogenesactivates RIG-I signaling" @default.
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- W2912187868 cites W2515669506 @default.
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- W2912187868 doi "https://doi.org/10.1101/543652" @default.
- W2912187868 hasPublicationYear "2019" @default.
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