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• W2912188645 abstract "Abstract Here, we reported on a one‐step fabrication of magnetite Fe 3 O 4 nanoparticles/indium tin oxide (ITO) electrode based on the direct growing of Fe 3 O 4 nanoparticles on the ITO surface by using a solvothermal process. The modified electrode was used as electrochemical methotrexate (MTX) biosensor with high sensitivity based on cyclic voltammetry and square wave voltammetry techniques. The results demonstrated a linear relationship between the MTX concentration and its oxidation current peak over a wide range from 10 −5 to 10 −14 mole/L with a limit of detection of 0.4×10 −15 M based on the square wave voltammetry (SWV) technique. In addition, Fe 3 O 4 /ITO electrode showed a good capability for measuring very low concentrations of MTX drug dissolved in human serum solution. Also, Fe 3 O 4 /ITO electrode was used for detecting MTX in blood serum samples collected from patients after their treatment with MTX. The prepared electrode showed the higher sensitivity that higher than the Viva‐E instrument, which opens the door for developing a cheap, simple and higher sensitive MTX sensor." @default.
• W2912188645 created "2019-02-21" @default.
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• W2912188645 date "2019-02-06" @default.
• W2912188645 modified "2023-10-16" @default.
• W2912188645 title "Electrochemical Monitoring of Methotrexate Anticancer Drug in Human Blood Serum by Using <i>in situ</i> Solvothermal Synthesized Fe ₃ O ₄ /ITO Electrode" @default.
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• W2912188645 doi "https://doi.org/10.1002/elan.201800798" @default.
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