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- W2912190697 abstract "Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. Here, we show that disrupting phosphorylation at Ser196 (S196A) in the liver X receptor alpha (LXRα, NR1H3) retards NAFLD progression in mice on a high-fat-high-cholesterol diet. Mechanistically, this is explained by key histone acetylation (H3K27) and transcriptional changes in pro-fibrotic and pro-inflammatory genes. Furthermore, S196A-LXRα expression reveals the regulation of novel diet-specific LXRα-responsive genes, including the induction of Ces1f, implicated in the breakdown of hepatic lipids. This involves induced H3K27 acetylation and altered LXR and TBLR1 cofactor occupancy at the Ces1f gene in S196A fatty livers. Overall, impaired Ser196-LXRα phosphorylation acts as a novel nutritional molecular sensor that profoundly alters the hepatic H3K27 acetylome and transcriptome during NAFLD progression placing LXRα phosphorylation as an alternative anti-inflammatory or anti-fibrotic therapeutic target." @default.
- W2912190697 created "2019-02-21" @default.
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- W2912190697 date "2019-01-01" @default.
- W2912190697 modified "2023-10-16" @default.
- W2912190697 title "Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease" @default.
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- W2912190697 cites W1981030303 @default.
- W2912190697 cites W1986577643 @default.
- W2912190697 cites W1996168740 @default.
- W2912190697 cites W2000119013 @default.
- W2912190697 cites W2003407162 @default.
- W2912190697 cites W2003507204 @default.
- W2912190697 cites W2005558543 @default.
- W2912190697 cites W2010381644 @default.
- W2912190697 cites W2010662354 @default.
- W2912190697 cites W2014677321 @default.
- W2912190697 cites W2014783744 @default.
- W2912190697 cites W2014864566 @default.
- W2912190697 cites W2021341670 @default.
- W2912190697 cites W2026958742 @default.
- W2912190697 cites W2029746435 @default.
- W2912190697 cites W2030708781 @default.
- W2912190697 cites W2032662504 @default.
- W2912190697 cites W2033883349 @default.
- W2912190697 cites W2039636142 @default.
- W2912190697 cites W2044267991 @default.
- W2912190697 cites W2048928105 @default.
- W2912190697 cites W2052495959 @default.
- W2912190697 cites W2064166253 @default.
- W2912190697 cites W2067042708 @default.
- W2912190697 cites W2070053386 @default.
- W2912190697 cites W2081832076 @default.
- W2912190697 cites W2081836486 @default.
- W2912190697 cites W2086486464 @default.
- W2912190697 cites W2090160141 @default.
- W2912190697 cites W2095905764 @default.
- W2912190697 cites W2095979483 @default.
- W2912190697 cites W2096958727 @default.
- W2912190697 cites W2104514782 @default.
- W2912190697 cites W2111675378 @default.
- W2912190697 cites W2112624239 @default.
- W2912190697 cites W2113653640 @default.
- W2912190697 cites W2120191409 @default.
- W2912190697 cites W2121509986 @default.
- W2912190697 cites W2126473569 @default.
- W2912190697 cites W2130410032 @default.
- W2912190697 cites W2137516998 @default.
- W2912190697 cites W2143812366 @default.
- W2912190697 cites W2145888094 @default.
- W2912190697 cites W2150291178 @default.
- W2912190697 cites W2152239989 @default.
- W2912190697 cites W2153673003 @default.
- W2912190697 cites W2155259249 @default.
- W2912190697 cites W2156914280 @default.
- W2912190697 cites W2157338541 @default.
- W2912190697 cites W2160272501 @default.
- W2912190697 cites W2256440089 @default.
- W2912190697 cites W2267287739 @default.
- W2912190697 cites W2310953154 @default.
- W2912190697 cites W2340814775 @default.
- W2912190697 cites W2345948424 @default.
- W2912190697 cites W2396984120 @default.
- W2912190697 cites W2408483783 @default.
- W2912190697 cites W2414763988 @default.
- W2912190697 cites W2442993638 @default.
- W2912190697 cites W2537083947 @default.
- W2912190697 cites W2551450955 @default.
- W2912190697 cites W2560190762 @default.
- W2912190697 cites W2570136952 @default.
- W2912190697 cites W2809945838 @default.
- W2912190697 cites W2918086501 @default.
- W2912190697 cites W3143409077 @default.
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- W2912190697 doi "https://doi.org/10.1016/j.celrep.2018.12.094" @default.
- W2912190697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6344342" @default.
- W2912190697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30673619" @default.
- W2912190697 hasPublicationYear "2019" @default.