FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912191870> ?p ?o ?g. }

• W2912191870 endingPage "106" @default.
• W2912191870 startingPage "97" @default.
• W2912191870 abstract "Dysregulation of nuclear and cytoplasmic O-linked β-N-acetylglucosamine (O-GlcNAc) cycling is implicated in a range of diseases including diabetes and cancer. This modification maintains cellular homeostasis by regulating several biological processes, such as cell signaling. This highly regulated cycle is governed by two sole essential enzymes, O-GlcNAc transferase and O-GlcNAcase that add O-GlcNAc and remove it from over a thousand substrates, respectively. Until recently, due to lack of structural information, the mechanism of substrate recognition has eluted researchers. Here, we review recent successes in structural characterization of these enzymes and how this information has illuminated key features essential for catalysis and substrate recognition. Additionally, we highlight recent studies which have used this information to expand our understanding of substrate specificity by each enzyme." @default.
• W2912191870 created "2019-02-21" @default.
• W2912191870 creator A5002715793 @default.
• W2912191870 creator A5032760318 @default.
• W2912191870 creator A5033965684 @default.
• W2912191870 creator A5035422570 @default.
• W2912191870 date "2019-06-01" @default.
• W2912191870 modified "2023-10-01" @default.
• W2912191870 title "Structural characterization of the O-GlcNAc cycling enzymes: insights into substrate recognition and catalytic mechanisms" @default.
• W2912191870 cites W1652316604 @default.
• W2912191870 cites W1763148417 @default.
• W2912191870 cites W1966824956 @default.
• W2912191870 cites W1981809260 @default.
• W2912191870 cites W1997087248 @default.
• W2912191870 cites W1999804990 @default.
• W2912191870 cites W2000777444 @default.
• W2912191870 cites W2002888609 @default.
• W2912191870 cites W2016015885 @default.
• W2912191870 cites W2022428368 @default.
• W2912191870 cites W2031087463 @default.
• W2912191870 cites W2031957765 @default.
• W2912191870 cites W2036574186 @default.
• W2912191870 cites W2041967294 @default.
• W2912191870 cites W2050775180 @default.
• W2912191870 cites W2051948190 @default.
• W2912191870 cites W2053975578 @default.
• W2912191870 cites W2056173710 @default.
• W2912191870 cites W2060744329 @default.
• W2912191870 cites W2068470826 @default.
• W2912191870 cites W2068805128 @default.
• W2912191870 cites W2069871720 @default.
• W2912191870 cites W2070991372 @default.
• W2912191870 cites W2080462728 @default.
• W2912191870 cites W2083232319 @default.
• W2912191870 cites W2083822728 @default.
• W2912191870 cites W2085890838 @default.
• W2912191870 cites W2090211150 @default.
• W2912191870 cites W2096306761 @default.
• W2912191870 cites W2100614964 @default.
• W2912191870 cites W2109361919 @default.
• W2912191870 cites W2110891602 @default.
• W2912191870 cites W2112921913 @default.
• W2912191870 cites W2113379985 @default.
• W2912191870 cites W2143963279 @default.
• W2912191870 cites W2146527846 @default.
• W2912191870 cites W2155290518 @default.
• W2912191870 cites W2180342052 @default.
• W2912191870 cites W2220881036 @default.
• W2912191870 cites W2347067222 @default.
• W2912191870 cites W2512633185 @default.
• W2912191870 cites W2520992849 @default.
• W2912191870 cites W2588058232 @default.
• W2912191870 cites W2588637571 @default.
• W2912191870 cites W2595453884 @default.
• W2912191870 cites W2601233071 @default.
• W2912191870 cites W2601432239 @default.
• W2912191870 cites W2603194836 @default.
• W2912191870 cites W2613539552 @default.
• W2912191870 cites W2727734411 @default.
• W2912191870 cites W2756444346 @default.
• W2912191870 cites W2789760611 @default.
• W2912191870 cites W2792569921 @default.
• W2912191870 cites W2795111905 @default.
• W2912191870 cites W2804899379 @default.
• W2912191870 cites W2895737508 @default.
• W2912191870 doi "https://doi.org/10.1016/j.sbi.2018.12.003" @default.
• W2912191870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6656603" @default.
• W2912191870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30708324" @default.
• W2912191870 hasPublicationYear "2019" @default.
• W2912191870 type Work @default.
• W2912191870 sameAs 2912191870 @default.
• W2912191870 citedByCount "56" @default.
• W2912191870 countsByYear W29121918702019 @default.
• W2912191870 countsByYear W29121918702020 @default.
• W2912191870 countsByYear W29121918702021 @default.
• W2912191870 countsByYear W29121918702022 @default.
• W2912191870 countsByYear W29121918702023 @default.
• W2912191870 crossrefType "journal-article" @default.
• W2912191870 hasAuthorship W2912191870A5002715793 @default.
• W2912191870 hasAuthorship W2912191870A5032760318 @default.
• W2912191870 hasAuthorship W2912191870A5033965684 @default.
• W2912191870 hasAuthorship W2912191870A5035422570 @default.
• W2912191870 hasBestOaLocation W29121918702 @default.
• W2912191870 hasConcept C181199279 @default.
• W2912191870 hasConcept C185592680 @default.
• W2912191870 hasConcept C18903297 @default.
• W2912191870 hasConcept C190062978 @default.
• W2912191870 hasConcept C2776376580 @default.
• W2912191870 hasConcept C2777289219 @default.
• W2912191870 hasConcept C55493867 @default.
• W2912191870 hasConcept C86803240 @default.
• W2912191870 hasConcept C95444343 @default.
• W2912191870 hasConceptScore W2912191870C181199279 @default.
• W2912191870 hasConceptScore W2912191870C185592680 @default.
• W2912191870 hasConceptScore W2912191870C18903297 @default.
• W2912191870 hasConceptScore W2912191870C190062978 @default.
• W2912191870 hasConceptScore W2912191870C2776376580 @default.
• W2912191870 hasConceptScore W2912191870C2777289219 @default.

• next