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- W2912192243 abstract "Infection with hepatitis C virus (HCV) is a major cause of chronic liver disease, with 130 to 170 million people infected worldwide. HCV is an RNA virus with six major genotypes and bloodborne transmission in the majority of cases. The spectrum of disease is wide, ranging from asymptomatic disease, to cirrhosis, hepatocellular carcinoma (HCC), and extrahepatic manifestations (mixed cryoglobulinemia, cutaneous vasculitis, non-Hodgkin lymphoma, chronic fatigue, insulin resistance). Currently, highly safe and effective antiviral treatments with direct-acting agents (DAAs) are available, leading to the cure of HCV infection (sustained virologic response [SVR]) in more than 95% of cases. Follow-up after SVR achievement is mandatory in patients with cirrhosis (surveillance for HCC) and those with other hepatic comorbidities (e.g., nonalcoholic fatty liver disease, alcohol consumption) or at risk of reinfection." @default.
- W2912192243 created "2019-02-21" @default.
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- W2912192243 date "2018-01-01" @default.
- W2912192243 modified "2023-09-28" @default.
- W2912192243 title "Hepatitis C" @default.
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- W2912192243 doi "https://doi.org/10.1016/b978-0-323-47874-8.00005-5" @default.
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