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- W2912196617 endingPage "347" @default.
- W2912196617 startingPage "325" @default.
- W2912196617 abstract "ATP, NAD + , and nucleic acids are abundant purines that, in addition to having critical intracellular functions, have evolved extracellular roles as danger signals released in response to cell lysis, apoptosis, degranulation, or membrane pore formation. In general ATP and NAD + have excitatory and adenosine has anti-inflammatory effects on immune cells. This review focuses on recent advances in our understanding of purine release mechanisms, ectoenzymes that metabolize purines (CD38, CD39, CD73, ENPP1, and ENPP2/autotaxin), and signaling by key P2 purinergic receptors (P2X7, P2Y2, and P2Y12). In addition to metabolizing ATP or NAD + , some purinergic ectoenzymes metabolize other inflammatory modulators, notably lysophosphatidic acid and cyclic GMP-AMP (cGAMP). Also discussed are extracellular signaling effects of NAD + mediated by ADP-ribosylation, and epigenetic effects of intracellular adenosine mediated by modification of S-adenosylmethionine-dependent DNA methylation." @default.
- W2912196617 created "2019-02-21" @default.
- W2912196617 creator A5003820941 @default.
- W2912196617 creator A5025561543 @default.
- W2912196617 creator A5062405338 @default.
- W2912196617 date "2019-04-26" @default.
- W2912196617 modified "2023-09-30" @default.
- W2912196617 title "Purine Release, Metabolism, and Signaling in the Inflammatory Response" @default.
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