Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912199078> ?p ?o ?g. }
- W2912199078 endingPage "1753" @default.
- W2912199078 startingPage "1739" @default.
- W2912199078 abstract "Cells need to synthesize and degrade proteins consistently. Maintaining a balanced level of protein in the cell requires a carefully controlled system and significant energy. Degradation of unwanted or damaged proteins into smaller peptide units can be accomplished by the proteasome. The proteasome is composed of two main subunits. The first is the core particle (20S CP), and within this core particle are three types of threonine proteases. The second is the regulatory complex (19S RP), which has a myriad of activities including recognizing proteins marked for degradation and shuttling the protein into the 20S CP to be degraded. Small-molecule inhibitors of the 20S CP have been developed and are exceptional treatments for multiple myeloma (MM). 20S CP inhibitors disrupt the protein balance, leading to cellular stress and eventually to cell death. Unfortunately, the 20S CP inhibitors currently available have dose-limiting off-target effects and resistance can be acquired rapidly. Herein, we discuss small molecules that have been discovered to interact with the 19S RP subunit or with a protein closely associated with 19S RP activity. These molecules still elicit their toxicity by preventing the proteasome from degrading proteins, but do so through different mechanisms of action." @default.
- W2912199078 created "2019-02-21" @default.
- W2912199078 creator A5023317651 @default.
- W2912199078 creator A5039471153 @default.
- W2912199078 creator A5063080832 @default.
- W2912199078 date "2019-05-24" @default.
- W2912199078 modified "2023-10-15" @default.
- W2912199078 title "Small‐Molecule Inhibitors of the Proteasome's Regulatory Particle" @default.
- W2912199078 cites W1496897161 @default.
- W2912199078 cites W1556287360 @default.
- W2912199078 cites W1706760553 @default.
- W2912199078 cites W1848935986 @default.
- W2912199078 cites W1933858120 @default.
- W2912199078 cites W1966533262 @default.
- W2912199078 cites W1969648097 @default.
- W2912199078 cites W1969795778 @default.
- W2912199078 cites W1973432561 @default.
- W2912199078 cites W1973963032 @default.
- W2912199078 cites W1974256456 @default.
- W2912199078 cites W1975462016 @default.
- W2912199078 cites W1978245328 @default.
- W2912199078 cites W1979824772 @default.
- W2912199078 cites W1981591191 @default.
- W2912199078 cites W1985286323 @default.
- W2912199078 cites W1991989590 @default.
- W2912199078 cites W1992671721 @default.
- W2912199078 cites W1993527939 @default.
- W2912199078 cites W1997012817 @default.
- W2912199078 cites W1999042605 @default.
- W2912199078 cites W2000872571 @default.
- W2912199078 cites W2011398252 @default.
- W2912199078 cites W2012265138 @default.
- W2912199078 cites W2012296420 @default.
- W2912199078 cites W2013218789 @default.
- W2912199078 cites W2013339424 @default.
- W2912199078 cites W2014593228 @default.
- W2912199078 cites W2014630160 @default.
- W2912199078 cites W2014697177 @default.
- W2912199078 cites W2016742872 @default.
- W2912199078 cites W2021957090 @default.
- W2912199078 cites W2031663826 @default.
- W2912199078 cites W2033088972 @default.
- W2912199078 cites W2035094622 @default.
- W2912199078 cites W2035145745 @default.
- W2912199078 cites W2038794428 @default.
- W2912199078 cites W2038949369 @default.
- W2912199078 cites W2040750197 @default.
- W2912199078 cites W2041390166 @default.
- W2912199078 cites W2041417196 @default.
- W2912199078 cites W2045533311 @default.
- W2912199078 cites W2047195231 @default.
- W2912199078 cites W2049127225 @default.
- W2912199078 cites W2049748848 @default.
- W2912199078 cites W2051458654 @default.
- W2912199078 cites W2052593879 @default.
- W2912199078 cites W2052742292 @default.
- W2912199078 cites W2059175716 @default.
- W2912199078 cites W2060544465 @default.
- W2912199078 cites W2061049933 @default.
- W2912199078 cites W2064012571 @default.
- W2912199078 cites W2066108468 @default.
- W2912199078 cites W2067911054 @default.
- W2912199078 cites W2068306128 @default.
- W2912199078 cites W2070367241 @default.
- W2912199078 cites W2071430789 @default.
- W2912199078 cites W2072714194 @default.
- W2912199078 cites W2075597028 @default.
- W2912199078 cites W2084842992 @default.
- W2912199078 cites W2085760247 @default.
- W2912199078 cites W2087847975 @default.
- W2912199078 cites W2096913764 @default.
- W2912199078 cites W2097164847 @default.
- W2912199078 cites W2101622956 @default.
- W2912199078 cites W2109615795 @default.
- W2912199078 cites W2109638794 @default.
- W2912199078 cites W2110385671 @default.
- W2912199078 cites W2116356926 @default.
- W2912199078 cites W2118755520 @default.
- W2912199078 cites W2120126900 @default.
- W2912199078 cites W2125571326 @default.
- W2912199078 cites W2126170617 @default.
- W2912199078 cites W2126753299 @default.
- W2912199078 cites W2128575955 @default.
- W2912199078 cites W2131232694 @default.
- W2912199078 cites W2133406524 @default.
- W2912199078 cites W2136583861 @default.
- W2912199078 cites W2138247679 @default.
- W2912199078 cites W2139364069 @default.
- W2912199078 cites W2140533536 @default.
- W2912199078 cites W2143538182 @default.
- W2912199078 cites W2150925238 @default.
- W2912199078 cites W2151683271 @default.
- W2912199078 cites W2154127938 @default.
- W2912199078 cites W2156739666 @default.
- W2912199078 cites W2162223351 @default.
- W2912199078 cites W2164253678 @default.
- W2912199078 cites W2166475702 @default.
- W2912199078 cites W2166790177 @default.