FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912201215> ?p ?o ?g. }

• W2912201215 endingPage "267" @default.
• W2912201215 startingPage "256" @default.
• W2912201215 abstract "BackgroundMost gastric cancers are diagnosed at an advanced or metastatic stage with poor prognosis and survival rate. Fatty acid 2-hydroxylase (FA2H) with high expression in stomach generates chiral (R)-2-hydroxy FAs ((R)-2-OHFAs) and regulates glucose utilization which is important for cell proliferation and invasiveness. We hypothesized that FA2H impacts gastric tumor growth and could represent a novel target to improve gastric cancer therapy.MethodsFA2H level in 117 human gastric tumors and its association with tumor growth, metastasis and overall survival were examined. Its roles and potential mechanisms in regulating tumor growth were studied by genetic and pharmacological manipulation of gastric cancer cells in vitro and in vivo.FindingsFA2H level was lower in gastric tumor tissues as compared to surrounding tissues and associated with clinicopathologic status of patients, which were confirmed by analyses of multiple published datasets. FA2H depletion decreased tumor chemosensitivity, partially due to inhibition of AMPK and activation of the mTOR/S6K1/Gli1 pathway. Conversely, FA2H overexpression or treatment with (R)-2-OHFAs had the opposite effects. In line with these in vitro observations, FA2H knockdown promoted tumor growth with increased level of tumor Gli1 in vivo. Moreover, (R)-2-OHFA treatment significantly decreased Gli1 level in gastric tumors and enhanced tumor chemosensitivity to cisplatin, while alleviating the chemotherapy-induced weight loss in mice.InterpretationOur results demonstrate that FA2H plays an important role in regulating Hh signaling and gastric tumor growth and suggest that (R)-2-OHFAs could be effective as nontoxic wide-spectrum drugs to promote chemosensitivity.FundGrants of NSF, NIH, and PAPD." @default.
• W2912201215 created "2019-02-21" @default.
• W2912201215 creator A5000927900 @default.
• W2912201215 creator A5004356555 @default.
• W2912201215 creator A5010409010 @default.
• W2912201215 creator A5019567141 @default.
• W2912201215 creator A5021354628 @default.
• W2912201215 creator A5028395604 @default.
• W2912201215 creator A5039715758 @default.
• W2912201215 creator A5040840218 @default.
• W2912201215 creator A5057392311 @default.
• W2912201215 creator A5068002195 @default.
• W2912201215 creator A5080912872 @default.
• W2912201215 creator A5090668922 @default.
• W2912201215 date "2019-03-01" @default.
• W2912201215 modified "2023-10-16" @default.
• W2912201215 title "Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer" @default.
• W2912201215 cites W1543042843 @default.
• W2912201215 cites W1865002969 @default.
• W2912201215 cites W1901404250 @default.
• W2912201215 cites W1965568759 @default.
• W2912201215 cites W1967299835 @default.
• W2912201215 cites W1971687228 @default.
• W2912201215 cites W1977534471 @default.
• W2912201215 cites W1978545732 @default.
• W2912201215 cites W1982606761 @default.
• W2912201215 cites W1988466138 @default.
• W2912201215 cites W1992727272 @default.
• W2912201215 cites W1999500450 @default.
• W2912201215 cites W2018644553 @default.
• W2912201215 cites W2023802690 @default.
• W2912201215 cites W2024426236 @default.
• W2912201215 cites W2025227520 @default.
• W2912201215 cites W2025760068 @default.
• W2912201215 cites W2027634841 @default.
• W2912201215 cites W2049397238 @default.
• W2912201215 cites W2053024016 @default.
• W2912201215 cites W2054588091 @default.
• W2912201215 cites W2059498883 @default.
• W2912201215 cites W2077316068 @default.
• W2912201215 cites W2079227501 @default.
• W2912201215 cites W2081098333 @default.
• W2912201215 cites W2093518370 @default.
• W2912201215 cites W2106367815 @default.
• W2912201215 cites W2107630487 @default.
• W2912201215 cites W2115059753 @default.
• W2912201215 cites W2116634113 @default.
• W2912201215 cites W2118894802 @default.
• W2912201215 cites W2146512944 @default.
• W2912201215 cites W2162871532 @default.
• W2912201215 cites W2234115940 @default.
• W2912201215 cites W2404577315 @default.
• W2912201215 cites W2417514493 @default.
• W2912201215 cites W2520320830 @default.
• W2912201215 cites W2528485638 @default.
• W2912201215 cites W2564181903 @default.
• W2912201215 cites W2566405543 @default.
• W2912201215 cites W2570522603 @default.
• W2912201215 cites W2572741715 @default.
• W2912201215 cites W2587433409 @default.
• W2912201215 cites W2730173749 @default.
• W2912201215 cites W2737735431 @default.
• W2912201215 cites W2790705492 @default.
• W2912201215 cites W2797332465 @default.
• W2912201215 cites W2797394051 @default.
• W2912201215 cites W2810177770 @default.
• W2912201215 cites W4211130279 @default.
• W2912201215 doi "https://doi.org/10.1016/j.ebiom.2019.01.066" @default.
• W2912201215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6441949" @default.
• W2912201215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30738828" @default.
• W2912201215 hasPublicationYear "2019" @default.
• W2912201215 type Work @default.
• W2912201215 sameAs 2912201215 @default.
• W2912201215 citedByCount "47" @default.
• W2912201215 countsByYear W29122012152019 @default.
• W2912201215 countsByYear W29122012152020 @default.
• W2912201215 countsByYear W29122012152021 @default.
• W2912201215 countsByYear W29122012152022 @default.
• W2912201215 countsByYear W29122012152023 @default.
• W2912201215 crossrefType "journal-article" @default.
• W2912201215 hasAuthorship W2912201215A5000927900 @default.
• W2912201215 hasAuthorship W2912201215A5004356555 @default.
• W2912201215 hasAuthorship W2912201215A5010409010 @default.
• W2912201215 hasAuthorship W2912201215A5019567141 @default.
• W2912201215 hasAuthorship W2912201215A5021354628 @default.
• W2912201215 hasAuthorship W2912201215A5028395604 @default.
• W2912201215 hasAuthorship W2912201215A5039715758 @default.
• W2912201215 hasAuthorship W2912201215A5040840218 @default.
• W2912201215 hasAuthorship W2912201215A5057392311 @default.
• W2912201215 hasAuthorship W2912201215A5068002195 @default.
• W2912201215 hasAuthorship W2912201215A5080912872 @default.
• W2912201215 hasAuthorship W2912201215A5090668922 @default.
• W2912201215 hasBestOaLocation W29122012151 @default.
• W2912201215 hasConcept C121608353 @default.
• W2912201215 hasConcept C126322002 @default.
• W2912201215 hasConcept C150903083 @default.
• W2912201215 hasConcept C173396325 @default.
• W2912201215 hasConcept C190283241 @default.

• next