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- W2912205559 abstract "Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain. The descending noradrenergic inhibitory system from the locus coeruleus (LC) to the dorsal horn of the spinal cord plays an important role in the analgesic mechanisms of these drugs. Gabapentinoids activate the LC by inhibiting the release of γ-aminobutyric acid (GABA) and inducing the release of glutamate, thereby increasing noradrenaline levels in the spinal cord. Antidepressants increase noradrenaline levels in the spinal cord by inhibiting reuptake, and accumulating noradrenaline inhibits chronic pain through α2-adrenergic receptors in the spinal cord. Recent animal studies, however, revealed that the function of the descending noradrenergic inhibitory system is impaired in chronic pain states. Other recent studies found that histone deacetylase inhibitors and antidepressants restore the impaired noradrenergic descending inhibitory system acting on noradrenergic neurons in the LC." @default.
- W2912205559 created "2019-02-21" @default.
- W2912205559 creator A5025636438 @default.
- W2912205559 creator A5047968747 @default.
- W2912205559 date "2019-02-14" @default.
- W2912205559 modified "2023-10-04" @default.
- W2912205559 title "Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System" @default.
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- W2912205559 doi "https://doi.org/10.3390/ijms20040822" @default.
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