Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912206325> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2912206325 endingPage "227" @default.
- W2912206325 startingPage "225" @default.
- W2912206325 abstract "Increased During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation and severity of injury. Secretion of anti-inflammatory mediators is a mechanism that is critical in controlling inflammatory responses and promoting epithelial restitution and barrier recovery. Annexin A1 (AnxA1) is a potent anti-inflammatory protein that has been implicated to play a critical immune regulatory role in models of inflammation. Although anxA1 has been shown to be secreted in intestinal mucosal tissues during inflammation, its potential role in modulating the injury/inflammatory response is not understood. In this study, we demonstrate that AnxA1-deficient animals exhibit increased susceptibility to dextran sulfate sodium (DSS)-induced colitis with greater clinical morbidity and histopathologic mucosal injury. Furthermore, impaired recovery following withdrawal of DSS administration was observed in AnxA1 (−/−) animals compared with wild-type (WT) control mice that was independent of inflammatory cell infiltration. Since AnxA1 exerts its anti-inflammatory properties through stimulation of ALX/FPRL-1, we explored the role of this receptor-ligand interaction in regulating DSS-induced colitis. Interestingly, treatment with an ALX/FPRL-1 agonist, 15-epi-lipoxin A4 reversed the enhanced sensitivity of AnxA1 (−/−) mice to DSS colitis. In contrast, 15-epi-lipoxin A4 did not significantly improve the severity of disease in WT animals. Additionally, differential expression of ALX/FPLR-1 in control and DSS-treated WT and AnxA1-deficient animals suggested a potential role for AnxA1 in regulating ALX/FPRL-1 expression under pathophysiological conditions. Together, these results support a role of endogenous AnxA1 in the protective and reparative properties of the intestinal mucosal epithelium." @default.
- W2912206325 created "2019-02-21" @default.
- W2912206325 creator A5007326290 @default.
- W2912206325 creator A5016097947 @default.
- W2912206325 creator A5026556414 @default.
- W2912206325 creator A5030624991 @default.
- W2912206325 creator A5030974804 @default.
- W2912206325 creator A5039273714 @default.
- W2912206325 creator A5042841599 @default.
- W2912206325 creator A5054260081 @default.
- W2912206325 creator A5061560865 @default.
- W2912206325 creator A5069460640 @default.
- W2912206325 creator A5073668017 @default.
- W2912206325 creator A5074708797 @default.
- W2912206325 date "2009-01-01" @default.
- W2912206325 modified "2023-09-27" @default.
- W2912206325 title "Annexin A1 regulates intestinal mucosal injury, inflammation, and repair" @default.
- W2912206325 cites W1855226200 @default.
- W2912206325 cites W1922367465 @default.
- W2912206325 cites W1994389789 @default.
- W2912206325 cites W2151868528 @default.
- W2912206325 doi "https://doi.org/10.1007/978-3-642-00625-8_84" @default.
- W2912206325 hasPublicationYear "2009" @default.
- W2912206325 type Work @default.
- W2912206325 sameAs 2912206325 @default.
- W2912206325 citedByCount "0" @default.
- W2912206325 crossrefType "book-chapter" @default.
- W2912206325 hasAuthorship W2912206325A5007326290 @default.
- W2912206325 hasAuthorship W2912206325A5016097947 @default.
- W2912206325 hasAuthorship W2912206325A5026556414 @default.
- W2912206325 hasAuthorship W2912206325A5030624991 @default.
- W2912206325 hasAuthorship W2912206325A5030974804 @default.
- W2912206325 hasAuthorship W2912206325A5039273714 @default.
- W2912206325 hasAuthorship W2912206325A5042841599 @default.
- W2912206325 hasAuthorship W2912206325A5054260081 @default.
- W2912206325 hasAuthorship W2912206325A5061560865 @default.
- W2912206325 hasAuthorship W2912206325A5069460640 @default.
- W2912206325 hasAuthorship W2912206325A5073668017 @default.
- W2912206325 hasAuthorship W2912206325A5074708797 @default.
- W2912206325 hasConcept C126322002 @default.
- W2912206325 hasConcept C164027704 @default.
- W2912206325 hasConcept C170493617 @default.
- W2912206325 hasConcept C203014093 @default.
- W2912206325 hasConcept C2775862500 @default.
- W2912206325 hasConcept C2776731609 @default.
- W2912206325 hasConcept C2776914184 @default.
- W2912206325 hasConcept C54166955 @default.
- W2912206325 hasConcept C553184892 @default.
- W2912206325 hasConcept C68246026 @default.
- W2912206325 hasConcept C71924100 @default.
- W2912206325 hasConcept C88634738 @default.
- W2912206325 hasConcept C8891405 @default.
- W2912206325 hasConceptScore W2912206325C126322002 @default.
- W2912206325 hasConceptScore W2912206325C164027704 @default.
- W2912206325 hasConceptScore W2912206325C170493617 @default.
- W2912206325 hasConceptScore W2912206325C203014093 @default.
- W2912206325 hasConceptScore W2912206325C2775862500 @default.
- W2912206325 hasConceptScore W2912206325C2776731609 @default.
- W2912206325 hasConceptScore W2912206325C2776914184 @default.
- W2912206325 hasConceptScore W2912206325C54166955 @default.
- W2912206325 hasConceptScore W2912206325C553184892 @default.
- W2912206325 hasConceptScore W2912206325C68246026 @default.
- W2912206325 hasConceptScore W2912206325C71924100 @default.
- W2912206325 hasConceptScore W2912206325C88634738 @default.
- W2912206325 hasConceptScore W2912206325C8891405 @default.
- W2912206325 hasLocation W29122063251 @default.
- W2912206325 hasOpenAccess W2912206325 @default.
- W2912206325 hasPrimaryLocation W29122063251 @default.
- W2912206325 hasRelatedWork W1495484029 @default.
- W2912206325 hasRelatedWork W1503364336 @default.
- W2912206325 hasRelatedWork W2032631731 @default.
- W2912206325 hasRelatedWork W2083619020 @default.
- W2912206325 hasRelatedWork W2148123030 @default.
- W2912206325 hasRelatedWork W2154542694 @default.
- W2912206325 hasRelatedWork W2754063779 @default.
- W2912206325 hasRelatedWork W2912206325 @default.
- W2912206325 hasRelatedWork W3036604574 @default.
- W2912206325 hasRelatedWork W3173827935 @default.
- W2912206325 isParatext "false" @default.
- W2912206325 isRetracted "false" @default.
- W2912206325 magId "2912206325" @default.
- W2912206325 workType "book-chapter" @default.