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- W2912207327 abstract "A novel tetracationic porphyrin-platinum(II) conjugate was synthesized and characterized. This complex, 4Pt(dach)ClTPyP, showed reasonable water solubility, lack of aggregation, and high singlet oxygen quantum yield. It also exhibited low dark cytotoxicity and excellent photocytotoxicity (Colon26: 0.17 µM; Sarcoma180: 0.25 µM). The mechanisms of cell death have been investigated and are attributed to high singlet oxygen generation, internalization into nucleus, and a caspase-3 induced apoptosis pathway. In the in vivo photodynamic therapy (PDT) assay, 4Pt(dach)ClTPyP completely killed tumor tissue, not simply displaying inhibition of tumor growth, and no recurrence was seen 18 days later after a single administration. All these findings of 4Pt(dach)ClTPyP shed light on a potential clinical use for cancer PDT in the future. A water-soluble tetracationic porphyrin-platinum(II) conjugate was synthesized for photodynamic therapy (PDT) with low dark cytotoxicity and excellent photocytotoxicity. The mechanisms of cell death are attributed to high singlet oxygen generation, internalization into nuclei, and a caspase-3 induced apoptosis pathway. Strikingly, this complex completely killed tumor cells, and no recurrence was seen 18 days later after a single administration." @default.
- W2912207327 created "2019-02-21" @default.
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- W2912207327 date "2019-04-15" @default.
- W2912207327 modified "2023-09-25" @default.
- W2912207327 title "A Platinum Functional Porphyrin Conjugate: An Excellent Cancer Killer for Photodynamic Therapy" @default.
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- W2912207327 doi "https://doi.org/10.1246/bcsj.20180382" @default.
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