FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912207490> ?p ?o ?g. }

• W2912207490 endingPage "e0212138" @default.
• W2912207490 startingPage "e0212138" @default.
• W2912207490 abstract "Accumulating evidence suggests that neuroinflammation and oxidative stress in cardiovascular center contribute to the pathological processes underlying hypertension. Microglia activation triggers the inflammation and oxidative stress. Melatonin is a documented potent anti-inflammatory regent and antioxidant, the underlying roles of melatonin in regulating microglia activation via mitochondria remain unclear. In present study, we investigated the protective role of melatonin in decreasing M1 phenotype switching via attenuating mitochondrial oxidative damage in dependence on uncoupling protein 2 (UCP2) pathway in microglia. Prorenin (20 nmol/L; 24 hr) was used to induce inflammation in cultured microglia. Mitochondrial morphology was detected by transmission electron microscope. The reactive oxygen species (ROS) production by using DCFH-DA fluorescence imaging and mitochondrial membrane potential (MMP, ΔΨm) was evaluated by JC-1 staining. The indicator of the redox status as the ratio of the amount of total NADP+ to total NADPH, and the expression of 6 subunits of NADPH oxidase is measured. The pro-inflammatory cytokines releasing was measured by qPCR. UCP2 and activated AMPKα (p-AMPKα) expression were examined by immunoblot. Melatonin (100 μM) markedly alleviated the M1 microglia phenotype shifting and abnormal mitochondria morphology. Melatonin attenuated prorenin-induced ΔΨm increasing and ROS overproduction. Melatonin decreased the redox ratio (NADP+/NADPH) and the p47phox and gp91phox subunits of NADPH oxidase expression in prorenin-treated microglia. These effects were reversed in the presence of UCP2 siRNA. Our results suggested that the protective effect of melatonin against prorenin-induced M1 phenotype switching via attenuating mitochondrial oxidative damage depending on UCP2 upregulation in prorenin-treated microglia." @default.
• W2912207490 created "2019-02-21" @default.
• W2912207490 creator A5000168049 @default.
• W2912207490 creator A5007433652 @default.
• W2912207490 creator A5011969581 @default.
• W2912207490 creator A5017436081 @default.
• W2912207490 creator A5042750526 @default.
• W2912207490 creator A5061112555 @default.
• W2912207490 creator A5076678394 @default.
• W2912207490 creator A5077693662 @default.
• W2912207490 creator A5078320606 @default.
• W2912207490 date "2019-02-11" @default.
• W2912207490 modified "2023-10-16" @default.
• W2912207490 title "Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia" @default.
• W2912207490 cites W1505128349 @default.
• W2912207490 cites W1531336753 @default.
• W2912207490 cites W1718689468 @default.
• W2912207490 cites W184292044 @default.
• W2912207490 cites W1972721144 @default.
• W2912207490 cites W1975515886 @default.
• W2912207490 cites W1985941702 @default.
• W2912207490 cites W1986061017 @default.
• W2912207490 cites W1986399270 @default.
• W2912207490 cites W1987713053 @default.
• W2912207490 cites W2007819548 @default.
• W2912207490 cites W2049453065 @default.
• W2912207490 cites W2058158588 @default.
• W2912207490 cites W2059177685 @default.
• W2912207490 cites W2063583276 @default.
• W2912207490 cites W2064173000 @default.
• W2912207490 cites W2069090028 @default.
• W2912207490 cites W2069893872 @default.
• W2912207490 cites W2074493657 @default.
• W2912207490 cites W2081534285 @default.
• W2912207490 cites W2097588095 @default.
• W2912207490 cites W2098961218 @default.
• W2912207490 cites W2123338440 @default.
• W2912207490 cites W2126337135 @default.
• W2912207490 cites W2130858651 @default.
• W2912207490 cites W2155643523 @default.
• W2912207490 cites W2173768888 @default.
• W2912207490 cites W2265537272 @default.
• W2912207490 cites W2280120762 @default.
• W2912207490 cites W2345442422 @default.
• W2912207490 cites W2405823615 @default.
• W2912207490 cites W2415427537 @default.
• W2912207490 cites W2470437549 @default.
• W2912207490 cites W2517341189 @default.
• W2912207490 cites W2527692420 @default.
• W2912207490 cites W2581521665 @default.
• W2912207490 cites W2744195772 @default.
• W2912207490 cites W2746450304 @default.
• W2912207490 cites W2753148939 @default.
• W2912207490 cites W2757938655 @default.
• W2912207490 cites W2779167696 @default.
• W2912207490 cites W2783468975 @default.
• W2912207490 cites W2791964121 @default.
• W2912207490 cites W2794941358 @default.
• W2912207490 cites W2808478013 @default.
• W2912207490 cites W2810417423 @default.
• W2912207490 cites W2883874550 @default.
• W2912207490 cites W2887456892 @default.
• W2912207490 cites W2888823044 @default.
• W2912207490 cites W2889422847 @default.
• W2912207490 cites W2908491768 @default.
• W2912207490 doi "https://doi.org/10.1371/journal.pone.0212138" @default.
• W2912207490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6370243" @default.
• W2912207490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742657" @default.
• W2912207490 hasPublicationYear "2019" @default.
• W2912207490 type Work @default.
• W2912207490 sameAs 2912207490 @default.
• W2912207490 citedByCount "29" @default.
• W2912207490 countsByYear W29122074902019 @default.
• W2912207490 countsByYear W29122074902020 @default.
• W2912207490 countsByYear W29122074902021 @default.
• W2912207490 countsByYear W29122074902022 @default.
• W2912207490 countsByYear W29122074902023 @default.
• W2912207490 crossrefType "journal-article" @default.
• W2912207490 hasAuthorship W2912207490A5000168049 @default.
• W2912207490 hasAuthorship W2912207490A5007433652 @default.
• W2912207490 hasAuthorship W2912207490A5011969581 @default.
• W2912207490 hasAuthorship W2912207490A5017436081 @default.
• W2912207490 hasAuthorship W2912207490A5042750526 @default.
• W2912207490 hasAuthorship W2912207490A5061112555 @default.
• W2912207490 hasAuthorship W2912207490A5076678394 @default.
• W2912207490 hasAuthorship W2912207490A5077693662 @default.
• W2912207490 hasAuthorship W2912207490A5078320606 @default.
• W2912207490 hasBestOaLocation W29122074901 @default.
• W2912207490 hasConcept C134018914 @default.
• W2912207490 hasConcept C185592680 @default.
• W2912207490 hasConcept C203014093 @default.
• W2912207490 hasConcept C2776151105 @default.
• W2912207490 hasConcept C2776914184 @default.
• W2912207490 hasConcept C2777209548 @default.
• W2912207490 hasConcept C2778182776 @default.
• W2912207490 hasConcept C2779719074 @default.
• W2912207490 hasConcept C2779830541 @default.
• W2912207490 hasConcept C28859421 @default.

• next