Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912211980> ?p ?o ?g. }
- W2912211980 endingPage "515" @default.
- W2912211980 startingPage "503" @default.
- W2912211980 abstract "Radiation-induced lung injury is a delayed effect of acute radiation exposure resulting in pulmonary pneumonitis and fibrosis. Molecular mechanisms that lead to radiation-induced lung injury remain incompletely understood. Using a murine model of whole-thorax lung irradiation, C57BL/6J mice were irradiated at 8, 10, 12, and 14 Gy and assayed at day 1, 3, and 6 postexposure and compared to nonirradiated (sham) controls. Tryptic digests of lung tissues were analyzed by liquid chromatography-tandem mass spectrometry on a Waters nanoLC instrument coupled to a Thermo Scientific Q Exactive hybrid quadrupole-orbitrap mass spectrometer. Pathway and gene ontology analysis were performed with Qiagen Ingenuity, Panther GO, and DAVID databases. A number of trends were identified in the proteomic data, including protein changes greater than 10 fold, protein changes that were consistently up regulated or down regulated at all time points and dose levels interrogated, time and dose dependency of protein changes, canonical pathways affected by irradiation, changes in proteins that serve as upstream regulators, and proteins involved in key processes including inflammation, radiation, and retinoic acid signaling. The proteomic profiling conducted here represents an untargeted systems biology approach to identify acute molecular events that could potentially be initiating events for radiation-induced lung injury." @default.
- W2912211980 created "2019-02-21" @default.
- W2912211980 creator A5010668315 @default.
- W2912211980 creator A5015749452 @default.
- W2912211980 creator A5022533285 @default.
- W2912211980 creator A5064021094 @default.
- W2912211980 creator A5069095946 @default.
- W2912211980 creator A5078738730 @default.
- W2912211980 creator A5081639369 @default.
- W2912211980 creator A5085873334 @default.
- W2912211980 date "2019-04-01" @default.
- W2912211980 modified "2023-10-03" @default.
- W2912211980 title "Acute Proteomic Changes in the Lung After WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure" @default.
- W2912211980 cites W1588479784 @default.
- W2912211980 cites W1644889756 @default.
- W2912211980 cites W1855248889 @default.
- W2912211980 cites W1957311725 @default.
- W2912211980 cites W1967347847 @default.
- W2912211980 cites W1969186966 @default.
- W2912211980 cites W1971010914 @default.
- W2912211980 cites W1980516263 @default.
- W2912211980 cites W1981069524 @default.
- W2912211980 cites W1988500778 @default.
- W2912211980 cites W1991180497 @default.
- W2912211980 cites W1992893455 @default.
- W2912211980 cites W1993743449 @default.
- W2912211980 cites W1993929076 @default.
- W2912211980 cites W1997363973 @default.
- W2912211980 cites W1999250341 @default.
- W2912211980 cites W2006228102 @default.
- W2912211980 cites W2006693926 @default.
- W2912211980 cites W2012428888 @default.
- W2912211980 cites W2013424455 @default.
- W2912211980 cites W2015911650 @default.
- W2912211980 cites W2020093028 @default.
- W2912211980 cites W2023655541 @default.
- W2912211980 cites W2024692400 @default.
- W2912211980 cites W2025242995 @default.
- W2912211980 cites W2029568919 @default.
- W2912211980 cites W2030829559 @default.
- W2912211980 cites W2032897155 @default.
- W2912211980 cites W2043433501 @default.
- W2912211980 cites W2046623862 @default.
- W2912211980 cites W2046890186 @default.
- W2912211980 cites W2046927378 @default.
- W2912211980 cites W2050750337 @default.
- W2912211980 cites W2051840532 @default.
- W2912211980 cites W2053943711 @default.
- W2912211980 cites W2056462710 @default.
- W2912211980 cites W2057955197 @default.
- W2912211980 cites W2068149369 @default.
- W2912211980 cites W2068811688 @default.
- W2912211980 cites W2077527117 @default.
- W2912211980 cites W2078243876 @default.
- W2912211980 cites W2095504560 @default.
- W2912211980 cites W2097227447 @default.
- W2912211980 cites W2097931810 @default.
- W2912211980 cites W2098371880 @default.
- W2912211980 cites W2100379694 @default.
- W2912211980 cites W2103009727 @default.
- W2912211980 cites W2108253531 @default.
- W2912211980 cites W2110436325 @default.
- W2912211980 cites W2126244930 @default.
- W2912211980 cites W2131122365 @default.
- W2912211980 cites W2138365237 @default.
- W2912211980 cites W2139728410 @default.
- W2912211980 cites W2143604781 @default.
- W2912211980 cites W2147075251 @default.
- W2912211980 cites W2150474714 @default.
- W2912211980 cites W2150729174 @default.
- W2912211980 cites W2151576881 @default.
- W2912211980 cites W2158217645 @default.
- W2912211980 cites W2162143298 @default.
- W2912211980 cites W2165243272 @default.
- W2912211980 cites W2166205211 @default.
- W2912211980 cites W2172184136 @default.
- W2912211980 cites W2326748514 @default.
- W2912211980 cites W2404022326 @default.
- W2912211980 cites W2470074376 @default.
- W2912211980 cites W2515078203 @default.
- W2912211980 cites W2536987917 @default.
- W2912211980 cites W2556878395 @default.
- W2912211980 cites W2559466477 @default.
- W2912211980 cites W2580424184 @default.
- W2912211980 cites W2591905057 @default.
- W2912211980 cites W2753184842 @default.
- W2912211980 cites W2759497087 @default.
- W2912211980 cites W2763226716 @default.
- W2912211980 cites W2793008795 @default.
- W2912211980 cites W2794146954 @default.
- W2912211980 cites W2802161700 @default.
- W2912211980 doi "https://doi.org/10.1097/hp.0000000000000956" @default.
- W2912211980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6384149" @default.
- W2912211980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30652977" @default.
- W2912211980 hasPublicationYear "2019" @default.
- W2912211980 type Work @default.
- W2912211980 sameAs 2912211980 @default.
- W2912211980 citedByCount "20" @default.