FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912213962> ?p ?o ?g. }

• W2912213962 endingPage "3344" @default.
• W2912213962 startingPage "3336" @default.
• W2912213962 abstract "The mechanisms of radiation-induced liver damage are poorly understood. We investigated if tumour necrosis factor (TNF)-α acts synergistically with irradiation, and how its activity is influenced by platelet endothelial cell adhesion molecule-1 (PECAM-1). We studied murine models of selective single-dose (25 Gy) liver irradiation with and without TNF-α application (2 μg/mouse; i.p.). In serum of wild-type (wt)-mice, irradiation induced a mild increase in hepatic damage marker aspartate aminotransferase (AST) in comparison to sham-irradiated controls. AST levels further increased in mice treated with both irradiation and TNF-α. Accordingly, elevated numbers of leucocytes and increased expression of the macrophage marker CD68 were observed in the liver of these mice. In parallel to hepatic damage, a consecutive decrease in expression of hepatic PECAM-1 was found in mice that received radiation or TNF-α treatment alone. The combination of radiation and TNF-α induced an additional significant decline of PECAM-1. Furthermore, increased expression of hepatic lipocalin-2 (LCN-2), a hepatoprotective protein, was detected at mRNA and protein levels after irradiation or TNF-α treatment alone and the combination of both. Signal transducer and activator of transcription-3 (STAT-3) seems to be involved in the signalling cascade. To study the involvement of PECAM-1 in hepatic damage more deeply, the liver of both wt- and PECAM-1-knock-out-mice were selectively irradiated (25 Gy). Thereby, ko-mice showed higher liver damage as revealed by elevated AST levels, but also increased hepatoprotective LCN-2 expression. Our studies show that TNF-α has a pivotal role in radiation-induced hepatic damage. It acts in concert with irradiation and its activity is modulated by PECAM-1, which mediates pro- and anti-inflammatory signalling." @default.
• W2912213962 created "2019-02-21" @default.
• W2912213962 creator A5008746601 @default.
• W2912213962 creator A5045983296 @default.
• W2912213962 creator A5055286711 @default.
• W2912213962 creator A5055539335 @default.
• W2912213962 creator A5078946071 @default.
• W2912213962 date "2019-02-14" @default.
• W2912213962 modified "2023-10-18" @default.
• W2912213962 title "<scp>PECAM</scp> ‐1 modulates liver damage induced by synergistic effects of <scp>TNF</scp> ‐α and irradiation" @default.
• W2912213962 cites W1531356670 @default.
• W2912213962 cites W1587403161 @default.
• W2912213962 cites W1790371439 @default.
• W2912213962 cites W1966565183 @default.
• W2912213962 cites W1968295892 @default.
• W2912213962 cites W1969529822 @default.
• W2912213962 cites W1969841262 @default.
• W2912213962 cites W1975650631 @default.
• W2912213962 cites W1983985556 @default.
• W2912213962 cites W1989535259 @default.
• W2912213962 cites W1989787732 @default.
• W2912213962 cites W1989951239 @default.
• W2912213962 cites W1994564275 @default.
• W2912213962 cites W2024703960 @default.
• W2912213962 cites W2026252047 @default.
• W2912213962 cites W2026913872 @default.
• W2912213962 cites W2035020334 @default.
• W2912213962 cites W2037813530 @default.
• W2912213962 cites W2065209779 @default.
• W2912213962 cites W2068946087 @default.
• W2912213962 cites W2069282550 @default.
• W2912213962 cites W2073315388 @default.
• W2912213962 cites W2076224494 @default.
• W2912213962 cites W2077772740 @default.
• W2912213962 cites W2077960163 @default.
• W2912213962 cites W2086467746 @default.
• W2912213962 cites W2099883737 @default.
• W2912213962 cites W2101573950 @default.
• W2912213962 cites W2152364499 @default.
• W2912213962 cites W2155772701 @default.
• W2912213962 cites W2170969360 @default.
• W2912213962 cites W2268856907 @default.
• W2912213962 cites W2558163233 @default.
• W2912213962 cites W2603276734 @default.
• W2912213962 cites W2749024757 @default.
• W2912213962 cites W2752254033 @default.
• W2912213962 cites W2765940931 @default.
• W2912213962 doi "https://doi.org/10.1111/jcmm.14224" @default.
• W2912213962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6484309" @default.
• W2912213962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30761739" @default.
• W2912213962 hasPublicationYear "2019" @default.
• W2912213962 type Work @default.
• W2912213962 sameAs 2912213962 @default.
• W2912213962 citedByCount "13" @default.
• W2912213962 countsByYear W29122139622019 @default.
• W2912213962 countsByYear W29122139622020 @default.
• W2912213962 countsByYear W29122139622021 @default.
• W2912213962 countsByYear W29122139622022 @default.
• W2912213962 countsByYear W29122139622023 @default.
• W2912213962 crossrefType "journal-article" @default.
• W2912213962 hasAuthorship W2912213962A5008746601 @default.
• W2912213962 hasAuthorship W2912213962A5045983296 @default.
• W2912213962 hasAuthorship W2912213962A5055286711 @default.
• W2912213962 hasAuthorship W2912213962A5055539335 @default.
• W2912213962 hasAuthorship W2912213962A5078946071 @default.
• W2912213962 hasBestOaLocation W29122139621 @default.
• W2912213962 hasConcept C126322002 @default.
• W2912213962 hasConcept C134018914 @default.
• W2912213962 hasConcept C16685009 @default.
• W2912213962 hasConcept C17991360 @default.
• W2912213962 hasConcept C185592680 @default.
• W2912213962 hasConcept C20299238 @default.
• W2912213962 hasConcept C203014093 @default.
• W2912213962 hasConcept C503630168 @default.
• W2912213962 hasConcept C71924100 @default.
• W2912213962 hasConcept C86803240 @default.
• W2912213962 hasConceptScore W2912213962C126322002 @default.
• W2912213962 hasConceptScore W2912213962C134018914 @default.
• W2912213962 hasConceptScore W2912213962C16685009 @default.
• W2912213962 hasConceptScore W2912213962C17991360 @default.
• W2912213962 hasConceptScore W2912213962C185592680 @default.
• W2912213962 hasConceptScore W2912213962C20299238 @default.
• W2912213962 hasConceptScore W2912213962C203014093 @default.
• W2912213962 hasConceptScore W2912213962C503630168 @default.
• W2912213962 hasConceptScore W2912213962C71924100 @default.
• W2912213962 hasConceptScore W2912213962C86803240 @default.
• W2912213962 hasFunder F4320320879 @default.
• W2912213962 hasIssue "5" @default.
• W2912213962 hasLocation W29122139621 @default.
• W2912213962 hasLocation W29122139622 @default.
• W2912213962 hasLocation W29122139623 @default.
• W2912213962 hasOpenAccess W2912213962 @default.
• W2912213962 hasPrimaryLocation W29122139621 @default.
• W2912213962 hasRelatedWork W1977918131 @default.
• W2912213962 hasRelatedWork W1990717759 @default.
• W2912213962 hasRelatedWork W2096284471 @default.
• W2912213962 hasRelatedWork W2127368998 @default.
• W2912213962 hasRelatedWork W2151614054 @default.

• next