FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912219910> ?p ?o ?g. }

• W2912219910 endingPage "178" @default.
• W2912219910 startingPage "167" @default.
• W2912219910 abstract "Exchange protein directly activated by cAMP (Epac) and protein kinase A are effectors for cAMP with distinct actions and regulatory mechanisms. Epac is a Rap guanine nucleotide exchange factor that activates Rap1; protein kinase C (PKC) is a major downstream target of Epac-Rap1 signaling that has been implicated in a variety of pathophysiological processes, including cardiac hypertrophy, cancer, and nociceptor sensitization leading to chronic pain. Despite the implication of both Epac and PKC in these processes, few downstream targets of Epac-PKC signaling have been identified. This study characterized the regulation of PKC activity downstream of Epac activation. Using an antibody that recognizes phospho-serine residues within the consensus sequence phosphorylated by PKC, we analyzed the 1-dimensional banding profile of PKC substrate protein phosphorylation from the Neuro2A mouse neuroblastoma cell line. Activation of Epac either indirectly by prostaglandin PGE2, or directly by 8-pCPT-2-O-Me-cAMP-AM (8pCpt), produced distinct PKC phospho-substrate protein bands that were suppressed by co-administration of the Epac inhibitor ESI09. Different PKC isoforms contributed to the induction of individual phospho-substrate bands, as determined using isoform-selective PKC inhibitors. Moreover, the banding profile after Epac activation was altered by disruption of the cytoskeleton, suggesting that the orchestration of Epac-dependent PKC signaling is regulated in part by interactions with the cytoskeleton. The approach described here provides an effective means to characterize Epac-dependent PKC activity." @default.
• W2912219910 created "2019-02-21" @default.
• W2912219910 creator A5008499445 @default.
• W2912219910 creator A5055778782 @default.
• W2912219910 date "2019-02-09" @default.
• W2912219910 modified "2023-10-14" @default.
• W2912219910 title "Phospho-substrate profiling of Epac-dependent protein kinase C activity" @default.
• W2912219910 cites W1492821183 @default.
• W2912219910 cites W1493688737 @default.
• W2912219910 cites W1576399086 @default.
• W2912219910 cites W1607077699 @default.
• W2912219910 cites W1669198605 @default.
• W2912219910 cites W1773827424 @default.
• W2912219910 cites W1885709862 @default.
• W2912219910 cites W1964171635 @default.
• W2912219910 cites W1966631841 @default.
• W2912219910 cites W1970264680 @default.
• W2912219910 cites W1977984619 @default.
• W2912219910 cites W1980166477 @default.
• W2912219910 cites W1983136275 @default.
• W2912219910 cites W1995757732 @default.
• W2912219910 cites W2000599011 @default.
• W2912219910 cites W2003266871 @default.
• W2912219910 cites W2011361041 @default.
• W2912219910 cites W2022674028 @default.
• W2912219910 cites W2024890764 @default.
• W2912219910 cites W2025986356 @default.
• W2912219910 cites W2027683776 @default.
• W2912219910 cites W2027733905 @default.
• W2912219910 cites W2036927953 @default.
• W2912219910 cites W2038796486 @default.
• W2912219910 cites W2043617365 @default.
• W2912219910 cites W2045739383 @default.
• W2912219910 cites W2066542032 @default.
• W2912219910 cites W2069542996 @default.
• W2912219910 cites W2077835151 @default.
• W2912219910 cites W2078037416 @default.
• W2912219910 cites W2079692165 @default.
• W2912219910 cites W2080115585 @default.
• W2912219910 cites W2083679329 @default.
• W2912219910 cites W2100400861 @default.
• W2912219910 cites W2101015984 @default.
• W2912219910 cites W2101773993 @default.
• W2912219910 cites W2106745178 @default.
• W2912219910 cites W2107572837 @default.
• W2912219910 cites W2112634792 @default.
• W2912219910 cites W2116052541 @default.
• W2912219910 cites W2133048708 @default.
• W2912219910 cites W2141261480 @default.
• W2912219910 cites W2144001627 @default.
• W2912219910 cites W2151014103 @default.
• W2912219910 cites W2152519078 @default.
• W2912219910 cites W2154242988 @default.
• W2912219910 cites W2155823638 @default.
• W2912219910 cites W2164751832 @default.
• W2912219910 cites W2171241069 @default.
• W2912219910 cites W2290636465 @default.
• W2912219910 cites W2327655421 @default.
• W2912219910 cites W2587472505 @default.
• W2912219910 cites W2602911020 @default.
• W2912219910 cites W2787338635 @default.
• W2912219910 cites W1963562631 @default.
• W2912219910 doi "https://doi.org/10.1007/s11010-019-03502-1" @default.
• W2912219910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7269517" @default.
• W2912219910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30739223" @default.
• W2912219910 hasPublicationYear "2019" @default.
• W2912219910 type Work @default.
• W2912219910 sameAs 2912219910 @default.
• W2912219910 citedByCount "1" @default.
• W2912219910 countsByYear W29122199102021 @default.
• W2912219910 crossrefType "journal-article" @default.
• W2912219910 hasAuthorship W2912219910A5008499445 @default.
• W2912219910 hasAuthorship W2912219910A5055778782 @default.
• W2912219910 hasBestOaLocation W29122199102 @default.
• W2912219910 hasConcept C11960822 @default.
• W2912219910 hasConcept C126619667 @default.
• W2912219910 hasConcept C184235292 @default.
• W2912219910 hasConcept C185592680 @default.
• W2912219910 hasConcept C195794163 @default.
• W2912219910 hasConcept C2776179587 @default.
• W2912219910 hasConcept C62478195 @default.
• W2912219910 hasConcept C86803240 @default.
• W2912219910 hasConcept C95444343 @default.
• W2912219910 hasConcept C97029542 @default.
• W2912219910 hasConceptScore W2912219910C11960822 @default.
• W2912219910 hasConceptScore W2912219910C126619667 @default.
• W2912219910 hasConceptScore W2912219910C184235292 @default.
• W2912219910 hasConceptScore W2912219910C185592680 @default.
• W2912219910 hasConceptScore W2912219910C195794163 @default.
• W2912219910 hasConceptScore W2912219910C2776179587 @default.
• W2912219910 hasConceptScore W2912219910C62478195 @default.
• W2912219910 hasConceptScore W2912219910C86803240 @default.
• W2912219910 hasConceptScore W2912219910C95444343 @default.
• W2912219910 hasConceptScore W2912219910C97029542 @default.
• W2912219910 hasFunder F4320337354 @default.
• W2912219910 hasIssue "1-2" @default.
• W2912219910 hasLocation W29122199101 @default.
• W2912219910 hasLocation W29122199102 @default.

• next