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• W2912226341 abstract "Some P2X3 receptor antagonists have been developed as new therapeutic drugs for pain. We discovered a novel chemotype of P2X3 receptor antagonists with a pyrrolinone skeleton. Because of SAR studies to improve bioavailability of lead compound 2, compound (R)-24 was identified, which showed an analgesic effect against neuropathic pain by oral administration. We constructed a human P2X3 homology model as a template for the zebrafish P2X4 receptor, which agreed with SAR studies of pyrrolinone derivatives." @default.
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• W2912226341 date "2019-03-01" @default.
• W2912226341 modified "2023-09-26" @default.
• W2912226341 title "Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds" @default.
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• W2912226341 doi "https://doi.org/10.1016/j.bmcl.2019.01.039" @default.
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