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• W2912226880 endingPage "3056" @default.
• W2912226880 startingPage "3041" @default.
• W2912226880 abstract "The mammalian visual system operates over an extended range of ambient light levels by switching between rod and cone photoreceptors. Rod-driven vision is sluggish, highly sensitive, and operates in dim or scotopic lights, whereas cone-driven vision is brisk, less sensitive, and operates in bright or photopic lights. At intermediate or mesopic lights, vision transitions seamlessly from rod-driven to cone-driven, despite the profound differences in rod and cone response dynamics. The neural mechanisms underlying such a smooth handoff are not understood. Using an operant behavior assay, electrophysiological recordings, and mathematical modeling we examined the neural underpinnings of the mesopic visual transition in mice of either sex. We found that rods, but not cones, drive visual sensitivity to temporal light variations over much of the mesopic range. Surprisingly, speeding up rod photoresponse recovery kinetics in transgenic mice improved visual sensitivity to slow temporal variations, in the range where perceptual sensitivity is governed by Weber's law of sensation. In contrast, physiological processes acting downstream from phototransduction limit sensitivity to high frequencies and temporal resolution. We traced the paradoxical control of visual temporal sensitivity to rod photoresponses themselves. A scenario emerges where perceptual sensitivity is limited by: (1) the kinetics of neural processes acting downstream from phototransduction in scotopic lights, (2) rod response kinetics in mesopic lights, and (3) cone response kinetics as light levels rise into the photopic range. SIGNIFICANCE STATEMENT Our ability to detect flickering lights is constrained by the dynamics of the slowest step in the visual pathway. Cone photoresponse kinetics limit visual temporal sensitivity in bright (photopic) lights, whereas mechanisms in the inner retina limit sensitivity in dim (scotopic) lights. The neural mechanisms underlying the transition between scotopic and photopic vision in mesopic lights, when both rods are cones are active, are unknown. This study provides a missing link in this mechanism by establishing that rod photoresponse kinetics limit temporal sensitivity during the mesopic transition. Surprisingly, this range is where Weber's Law of Sensation governs temporal contrast sensitivity in mouse. Our results will help guide future studies of complex and dynamic interactions between rod–cone signals in the mesopic retina." @default.
• W2912226880 created "2019-02-21" @default.
• W2912226880 creator A5023946553 @default.
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• W2912226880 creator A5060466936 @default.
• W2912226880 creator A5061541390 @default.
• W2912226880 creator A5080868714 @default.
• W2912226880 date "2019-02-08" @default.
• W2912226880 modified "2023-09-27" @default.
• W2912226880 title "Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision" @default.
• W2912226880 cites W103359763 @default.
• W2912226880 cites W1583347069 @default.
• W2912226880 cites W167647922 @default.
• W2912226880 cites W1963775556 @default.
• W2912226880 cites W1970525754 @default.
• W2912226880 cites W1974191268 @default.
• W2912226880 cites W1975149236 @default.
• W2912226880 cites W1978281876 @default.
• W2912226880 cites W1980746675 @default.
• W2912226880 cites W1981121080 @default.
• W2912226880 cites W1984820452 @default.
• W2912226880 cites W1991302410 @default.
• W2912226880 cites W1991397561 @default.
• W2912226880 cites W1995686520 @default.
• W2912226880 cites W1997328693 @default.
• W2912226880 cites W2001551561 @default.
• W2912226880 cites W2001830985 @default.
• W2912226880 cites W2008624261 @default.
• W2912226880 cites W2009477947 @default.
• W2912226880 cites W2009581014 @default.
• W2912226880 cites W2009866472 @default.
• W2912226880 cites W2011391168 @default.
• W2912226880 cites W2011815627 @default.
• W2912226880 cites W2012101359 @default.
• W2912226880 cites W2013870510 @default.
• W2912226880 cites W2019496637 @default.
• W2912226880 cites W2021366041 @default.
• W2912226880 cites W2021608851 @default.
• W2912226880 cites W2022995207 @default.
• W2912226880 cites W2023363363 @default.
• W2912226880 cites W2027705226 @default.
• W2912226880 cites W2027913059 @default.
• W2912226880 cites W2032616063 @default.
• W2912226880 cites W2037180653 @default.
• W2912226880 cites W2037959347 @default.
• W2912226880 cites W2038892197 @default.
• W2912226880 cites W2045353541 @default.
• W2912226880 cites W2046140095 @default.
• W2912226880 cites W2052856800 @default.
• W2912226880 cites W2053727162 @default.
• W2912226880 cites W2056792189 @default.
• W2912226880 cites W2061018962 @default.
• W2912226880 cites W2061019970 @default.
• W2912226880 cites W2061738739 @default.
• W2912226880 cites W2063616867 @default.
• W2912226880 cites W2066482151 @default.
• W2912226880 cites W2069279981 @default.
• W2912226880 cites W2072371408 @default.
• W2912226880 cites W2072660026 @default.
• W2912226880 cites W2074004811 @default.
• W2912226880 cites W2084631572 @default.
• W2912226880 cites W2086898522 @default.
• W2912226880 cites W2091000566 @default.
• W2912226880 cites W2092019931 @default.
• W2912226880 cites W2094530674 @default.
• W2912226880 cites W2095275859 @default.
• W2912226880 cites W2104641495 @default.
• W2912226880 cites W2110068672 @default.
• W2912226880 cites W2113569731 @default.
• W2912226880 cites W2116648972 @default.
• W2912226880 cites W2117095391 @default.
• W2912226880 cites W2117554950 @default.
• W2912226880 cites W2119139988 @default.
• W2912226880 cites W2120888005 @default.
• W2912226880 cites W2120989812 @default.
• W2912226880 cites W2123478947 @default.
• W2912226880 cites W2126666532 @default.
• W2912226880 cites W2129389055 @default.
• W2912226880 cites W2130293499 @default.
• W2912226880 cites W2147110925 @default.
• W2912226880 cites W2149904439 @default.
• W2912226880 cites W2151641540 @default.
• W2912226880 cites W2152096944 @default.
• W2912226880 cites W2153053400 @default.
• W2912226880 cites W2154130938 @default.
• W2912226880 cites W2155685651 @default.
• W2912226880 cites W2168198049 @default.
• W2912226880 cites W2168259443 @default.
• W2912226880 cites W2173501142 @default.
• W2912226880 cites W2304166642 @default.
• W2912226880 cites W2338281506 @default.
• W2912226880 cites W2498346220 @default.
• W2912226880 cites W2511908766 @default.
• W2912226880 cites W2527450994 @default.
• W2912226880 cites W2582049971 @default.
• W2912226880 cites W2596763768 @default.
• W2912226880 cites W2787645613 @default.
• W2912226880 cites W2805069612 @default.

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