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- W2912227533 abstract "The intestinal microbiota is a complex microbial community, with diverse and stable populations hosted by the gastrointestinal tract since birth. This ecosystem holds multiple anti-infectious, anti-inflammatory, and immune modulating roles decisive for intestinal homeostasis. Among these, colonization resistance refers to the dynamic antagonistic interactions between commensals and pathogenic flora. Hence, gut bacteria compete for the same intestinal niches and substrates, while also releasing antimicrobial substances such as bacteriocines and changing the environmental conditions. Short chain fatty acids (SCFAs) generated in anaerobic conditions prompt epigenetic regulatory mechanisms that favor a tolerogenic immune response. In addition, the commensal flora is involved in the synthesis of bactericidal products, namely secondary biliary acids or antimicrobial peptides (AMPs) such as cathellicidin-LL37, an immunomodulatory, antimicrobial, and wound healing peptide. Gut microbiota is protected through symbiotic relations with the hosting organism and by quorum sensing, a specific cell-to-cell communication system. Any alterations of these relationships favor the uncontrollable multiplication of the resident pathobionts or external entero-pathogens, prompting systemic translocations, inflammatory reactions, or exacerbations of bacterial virulence mechanisms (T6SS, T3SS) and ultimately lead to gastrointestinal or systemic infections. The article describes the metabolic and immunological mechanisms through which the intestinal microbiota is both an ally of the organism against enteric pathogens and an enemy that favors the development of infections." @default.
- W2912227533 created "2019-02-21" @default.
- W2912227533 creator A5025818885 @default.
- W2912227533 creator A5052425776 @default.
- W2912227533 creator A5089965977 @default.
- W2912227533 date "2019-01-23" @default.
- W2912227533 modified "2023-10-14" @default.
- W2912227533 title "Intestinal Microbiota as a Host Defense Mechanism to Infectious Threats" @default.
- W2912227533 cites W1609878941 @default.
- W2912227533 cites W1885689715 @default.
- W2912227533 cites W1902150932 @default.
- W2912227533 cites W1967069761 @default.
- W2912227533 cites W1969785428 @default.
- W2912227533 cites W1981884436 @default.
- W2912227533 cites W1984127959 @default.
- W2912227533 cites W1986734986 @default.
- W2912227533 cites W1987992874 @default.
- W2912227533 cites W1989213972 @default.
- W2912227533 cites W1990473825 @default.
- W2912227533 cites W1992174684 @default.
- W2912227533 cites W1992775178 @default.
- W2912227533 cites W1993830991 @default.
- W2912227533 cites W1999906527 @default.
- W2912227533 cites W2001439699 @default.
- W2912227533 cites W2002515063 @default.
- W2912227533 cites W2012151682 @default.
- W2912227533 cites W2019567610 @default.
- W2912227533 cites W2024220189 @default.
- W2912227533 cites W2025154140 @default.
- W2912227533 cites W2026028158 @default.
- W2912227533 cites W2026894676 @default.
- W2912227533 cites W2032347305 @default.
- W2912227533 cites W2038622845 @default.
- W2912227533 cites W2038640338 @default.
- W2912227533 cites W2039062534 @default.
- W2912227533 cites W2042333161 @default.
- W2912227533 cites W2045119680 @default.
- W2912227533 cites W2049506766 @default.
- W2912227533 cites W2051605214 @default.
- W2912227533 cites W2066013154 @default.
- W2912227533 cites W2067510388 @default.
- W2912227533 cites W2069697829 @default.
- W2912227533 cites W2072288157 @default.
- W2912227533 cites W2075702858 @default.
- W2912227533 cites W2079096624 @default.
- W2912227533 cites W2079183971 @default.
- W2912227533 cites W2081806698 @default.
- W2912227533 cites W2083089709 @default.
- W2912227533 cites W2085056743 @default.
- W2912227533 cites W2085991415 @default.
- W2912227533 cites W2088822458 @default.
- W2912227533 cites W2096305565 @default.
- W2912227533 cites W2096436144 @default.
- W2912227533 cites W2096666146 @default.
- W2912227533 cites W2097808005 @default.
- W2912227533 cites W2100415806 @default.
- W2912227533 cites W2104181153 @default.
- W2912227533 cites W2105510659 @default.
- W2912227533 cites W2105977974 @default.
- W2912227533 cites W2106411106 @default.
- W2912227533 cites W2110936821 @default.
- W2912227533 cites W2120950548 @default.
- W2912227533 cites W2123583755 @default.
- W2912227533 cites W2127347791 @default.
- W2912227533 cites W2130246343 @default.
- W2912227533 cites W2132533879 @default.
- W2912227533 cites W2135232490 @default.
- W2912227533 cites W2135728432 @default.
- W2912227533 cites W2138179648 @default.
- W2912227533 cites W2144524917 @default.
- W2912227533 cites W2145051098 @default.
- W2912227533 cites W2145725787 @default.
- W2912227533 cites W2153824781 @default.
- W2912227533 cites W2166155263 @default.
- W2912227533 cites W2276961144 @default.
- W2912227533 cites W2327863288 @default.
- W2912227533 cites W2338773685 @default.
- W2912227533 cites W2339099938 @default.
- W2912227533 cites W2346707626 @default.
- W2912227533 cites W2378497121 @default.
- W2912227533 cites W2409656339 @default.
- W2912227533 cites W2426632426 @default.
- W2912227533 cites W2528584693 @default.
- W2912227533 cites W2568502991 @default.
- W2912227533 cites W2591275674 @default.
- W2912227533 cites W2751799791 @default.
- W2912227533 cites W2764061533 @default.
- W2912227533 cites W2772209187 @default.
- W2912227533 cites W2782717206 @default.
- W2912227533 cites W2783426856 @default.
- W2912227533 cites W2794654115 @default.
- W2912227533 cites W2794833162 @default.
- W2912227533 cites W2801217456 @default.
- W2912227533 cites W2804026342 @default.
- W2912227533 cites W2809686336 @default.
- W2912227533 cites W2867917187 @default.
- W2912227533 cites W2891442164 @default.
- W2912227533 cites W4235885613 @default.
- W2912227533 cites W78526537 @default.
- W2912227533 cites W7992144 @default.