Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912227565> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2912227565 abstract "Aims: We have previously demonstrated that the poly-arginine peptides R18 and R18D are neuroprotective at 24 hours following intraluminal middle cerebral artery occlusion (MCAO) in the rat. Therefore, using an independent laboratory we examined the ability of R18 and R18D to improve functional outcomes after endothelin-1 (ET-1) induced MCAO in rats over 56 days post-stroke. Methods: Peptides were administered intravenously at 100, 300 or 1000 nmol/kg, 60 minutes after ET-1 induced MCAO. Multiple forelimb placing tests and horizontal ladder tests were performed post-stroke, and the neuroprotective peptide NA-1 (TAT-NR2Bpc), which is being assessed in Phase 3 clinical stroke trials, was used as a benchmark. Results: R18 (300 and 1000nmol/kg, respectively) was the most effective peptide to improve functional outcomes, followed by R18D (300 and 1000 nmol/kg, respectively), and NA-1 (300 and 100 nmol/kg, respectively). Furthermore, R18 at 300 and 1000 nmol/kg was the most effective treatment to restore pre-stroke animal body weight (post-stroke day 4 versus day 7 for saline, and days 5-7 for all other treatments), while R18 and R18D at 300 and 1000 nmol/kg, but not NA-1 also significantly reduced the number of animals requiring special care (hand feeding) 48 hours after stroke. Conclusion: In conclusion, this study confirms that R18 and R18D can improve long-term functional outcomes after stroke, and given the superior effectiveness of R18 over NA-1 in the present, as well as in our previous studies, justifies further evaluation in a non-human primate stroke model and in a clinical stroke trial." @default.
- W2912227565 created "2019-02-21" @default.
- W2912227565 creator A5033438689 @default.
- W2912227565 creator A5038773980 @default.
- W2912227565 creator A5049716242 @default.
- W2912227565 creator A5063808854 @default.
- W2912227565 creator A5068214104 @default.
- W2912227565 creator A5069230549 @default.
- W2912227565 creator A5081631578 @default.
- W2912227565 creator A5084014102 @default.
- W2912227565 date "2019-02-01" @default.
- W2912227565 modified "2023-09-26" @default.
- W2912227565 title "Abstract WP156: Poly-arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-induced Stroke in the Sprague Dawley Rat" @default.
- W2912227565 doi "https://doi.org/10.1161/str.50.suppl_1.wp156" @default.
- W2912227565 hasPublicationYear "2019" @default.
- W2912227565 type Work @default.
- W2912227565 sameAs 2912227565 @default.
- W2912227565 citedByCount "0" @default.
- W2912227565 crossrefType "journal-article" @default.
- W2912227565 hasAuthorship W2912227565A5033438689 @default.
- W2912227565 hasAuthorship W2912227565A5038773980 @default.
- W2912227565 hasAuthorship W2912227565A5049716242 @default.
- W2912227565 hasAuthorship W2912227565A5063808854 @default.
- W2912227565 hasAuthorship W2912227565A5068214104 @default.
- W2912227565 hasAuthorship W2912227565A5069230549 @default.
- W2912227565 hasAuthorship W2912227565A5081631578 @default.
- W2912227565 hasAuthorship W2912227565A5084014102 @default.
- W2912227565 hasConcept C126322002 @default.
- W2912227565 hasConcept C127413603 @default.
- W2912227565 hasConcept C185592680 @default.
- W2912227565 hasConcept C25498285 @default.
- W2912227565 hasConcept C2777397205 @default.
- W2912227565 hasConcept C2777468819 @default.
- W2912227565 hasConcept C2780645631 @default.
- W2912227565 hasConcept C42219234 @default.
- W2912227565 hasConcept C515207424 @default.
- W2912227565 hasConcept C55493867 @default.
- W2912227565 hasConcept C71924100 @default.
- W2912227565 hasConcept C78519656 @default.
- W2912227565 hasConceptScore W2912227565C126322002 @default.
- W2912227565 hasConceptScore W2912227565C127413603 @default.
- W2912227565 hasConceptScore W2912227565C185592680 @default.
- W2912227565 hasConceptScore W2912227565C25498285 @default.
- W2912227565 hasConceptScore W2912227565C2777397205 @default.
- W2912227565 hasConceptScore W2912227565C2777468819 @default.
- W2912227565 hasConceptScore W2912227565C2780645631 @default.
- W2912227565 hasConceptScore W2912227565C42219234 @default.
- W2912227565 hasConceptScore W2912227565C515207424 @default.
- W2912227565 hasConceptScore W2912227565C55493867 @default.
- W2912227565 hasConceptScore W2912227565C71924100 @default.
- W2912227565 hasConceptScore W2912227565C78519656 @default.
- W2912227565 hasIssue "Suppl_1" @default.
- W2912227565 hasLocation W29122275651 @default.
- W2912227565 hasOpenAccess W2912227565 @default.
- W2912227565 hasPrimaryLocation W29122275651 @default.
- W2912227565 hasRelatedWork W1982094574 @default.
- W2912227565 hasRelatedWork W2042804898 @default.
- W2912227565 hasRelatedWork W2045993936 @default.
- W2912227565 hasRelatedWork W2051886420 @default.
- W2912227565 hasRelatedWork W2059592631 @default.
- W2912227565 hasRelatedWork W2410554934 @default.
- W2912227565 hasRelatedWork W2549135832 @default.
- W2912227565 hasRelatedWork W2896982246 @default.
- W2912227565 hasRelatedWork W3038666778 @default.
- W2912227565 hasRelatedWork W2168702221 @default.
- W2912227565 hasVolume "50" @default.
- W2912227565 isParatext "false" @default.
- W2912227565 isRetracted "false" @default.
- W2912227565 magId "2912227565" @default.
- W2912227565 workType "article" @default.