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• W2912232848 startingPage "548" @default.
• W2912232848 abstract "Virulence induction in the Staphylococcus aureus is under the control of a quorum sensing (QS) circuit encoded by the accessory gene regulator (agr) locus. Allelic variation within agr produces four QS specificity groups, each producing a unique secreted autoinducer peptide (AIP) and receptor histidine kinase (RHK), AgrC. Cognate AIP-AgrC interactions activate virulence through a two-component signaling cascade, whereas non-cognate pairs are generally inhibitory. Here we pinpoint a key hydrogen-bonding interaction within AgrC that acts as a switch to convert helical motions propagating from the receptor sensor domain into changes in inter-domain association within the kinase module. AgrC mutants lacking this interaction are constitutively active in vitro and in vivo, the latter leading to a pronounced attenuation of S. aureus biofilm formation. Thus, our work sheds light on the regulation of this biomedically important RHK." @default.
• W2912232848 created "2019-02-21" @default.
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• W2912232848 date "2019-04-01" @default.
• W2912232848 modified "2023-10-15" @default.
• W2912232848 title "Identification of a Molecular Latch that Regulates Staphylococcal Virulence" @default.
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• W2912232848 doi "https://doi.org/10.1016/j.chembiol.2019.01.006" @default.
• W2912232848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6506218" @default.
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