FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912233058> ?p ?o ?g. }

• W2912233058 abstract "Triple negative breast cancer (TNBC) is a subtype of breast cancer of heterogeneous nature that is negative for estrogen receptor (ER), progesterone receptor (PR) and growth factor human epidermal 2 (HER2) following immunohistochemical analysis. TNBC is frequently characterized by relapse and reduced survival. To date, there is no targeted therapy for this type of cancer. Chemotherapy, radiotherapy, and surgery remain as the standard treatments options. The lack of a target therapy and the heterogeneity of TNBC highlight the need to seek new therapeutic options. In this study, fresh tissue samples of TNBC were analyzed with a panel of 48 driver genes (212 amplicons) that are likely to be therapeutic targets. We found intron variants, missense, stop gained and splicing variants in TP53, PIK3CA and FLT3 genes. Interestingly, all the analyzed samples had at least two variants in the TP53 gene, one being a drug response variant, rs1042522, found in 94% of our samples. We also found seven additional variants not previously reported in the TP53 gene, to the best of our knowledge, with probable deleterious characteristics of the tumor suppressor gene. We found four genetic variants in the PIK3CA gene, including two missense variants. The rs2491231 variant in the FLT3 gene was identified in 84% (16/19) of the samples, which not yet reported for TNBC, to the best of our knowledge. In conclusion, genetic variants in TP53 were found in all TNBC tumors, with rs1042522 being the most frequent (94% of TNBC biopsies), which had not been previously reported in TNBC. Also, we found two missense variants in the PIK3CA gene. These results justify the validation of these genetic variants in a large cohort, as well as the extensive study of their impact on the prognosis and therapy management of TBNC." @default.
• W2912233058 created "2019-02-21" @default.
• W2912233058 creator A5003283037 @default.
• W2912233058 creator A5007315529 @default.
• W2912233058 creator A5012477982 @default.
• W2912233058 creator A5018050764 @default.
• W2912233058 creator A5021741233 @default.
• W2912233058 creator A5032994476 @default.
• W2912233058 creator A5033768584 @default.
• W2912233058 creator A5041072453 @default.
• W2912233058 creator A5041589223 @default.
• W2912233058 creator A5041847366 @default.
• W2912233058 creator A5045169060 @default.
• W2912233058 creator A5050958883 @default.
• W2912233058 creator A5055269851 @default.
• W2912233058 creator A5073585994 @default.
• W2912233058 creator A5081104410 @default.
• W2912233058 creator A5083296540 @default.
• W2912233058 date "2019-01-29" @default.
• W2912233058 modified "2023-10-18" @default.
• W2912233058 title "Genetic alterations of triple negative breast cancer (TNBC) in women from Northeastern Mexico" @default.
• W2912233058 cites W1483775860 @default.
• W2912233058 cites W1595906092 @default.
• W2912233058 cites W1872860230 @default.
• W2912233058 cites W1966727713 @default.
• W2912233058 cites W1971843650 @default.
• W2912233058 cites W1974740818 @default.
• W2912233058 cites W1981306189 @default.
• W2912233058 cites W1991494214 @default.
• W2912233058 cites W2017187984 @default.
• W2912233058 cites W2028236537 @default.
• W2912233058 cites W2035794058 @default.
• W2912233058 cites W2042563326 @default.
• W2912233058 cites W2044702943 @default.
• W2912233058 cites W2050328564 @default.
• W2912233058 cites W2063382533 @default.
• W2912233058 cites W2065991664 @default.
• W2912233058 cites W2072224532 @default.
• W2912233058 cites W2075230059 @default.
• W2912233058 cites W2083730819 @default.
• W2912233058 cites W2084831115 @default.
• W2912233058 cites W2089584150 @default.
• W2912233058 cites W2096027508 @default.
• W2912233058 cites W2101943966 @default.
• W2912233058 cites W2109991075 @default.
• W2912233058 cites W2112396116 @default.
• W2912233058 cites W2118526609 @default.
• W2912233058 cites W2118605519 @default.
• W2912233058 cites W2129172946 @default.
• W2912233058 cites W2141563900 @default.
• W2912233058 cites W2147621323 @default.
• W2912233058 cites W2150575159 @default.
• W2912233058 cites W2151835067 @default.
• W2912233058 cites W2154608911 @default.
• W2912233058 cites W2157285286 @default.
• W2912233058 cites W2160436448 @default.
• W2912233058 cites W2210624024 @default.
• W2912233058 cites W2288244492 @default.
• W2912233058 cites W2291633332 @default.
• W2912233058 cites W2336387305 @default.
• W2912233058 cites W2520938304 @default.
• W2912233058 cites W2560367415 @default.
• W2912233058 cites W2564100941 @default.
• W2912233058 cites W2575087935 @default.
• W2912233058 cites W2612764768 @default.
• W2912233058 cites W2715749014 @default.
• W2912233058 cites W2786784128 @default.
• W2912233058 cites W2811413018 @default.
• W2912233058 cites W2889646458 @default.
• W2912233058 cites W306640786 @default.
• W2912233058 cites W4237730881 @default.
• W2912233058 doi "https://doi.org/10.3892/ol.2019.9984" @default.
• W2912233058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6396222" @default.
• W2912233058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30867801" @default.
• W2912233058 hasPublicationYear "2019" @default.
• W2912233058 type Work @default.
• W2912233058 sameAs 2912233058 @default.
• W2912233058 citedByCount "8" @default.
• W2912233058 countsByYear W29122330582019 @default.
• W2912233058 countsByYear W29122330582020 @default.
• W2912233058 countsByYear W29122330582021 @default.
• W2912233058 countsByYear W29122330582022 @default.
• W2912233058 countsByYear W29122330582023 @default.
• W2912233058 crossrefType "journal-article" @default.
• W2912233058 hasAuthorship W2912233058A5003283037 @default.
• W2912233058 hasAuthorship W2912233058A5007315529 @default.
• W2912233058 hasAuthorship W2912233058A5012477982 @default.
• W2912233058 hasAuthorship W2912233058A5018050764 @default.
• W2912233058 hasAuthorship W2912233058A5021741233 @default.
• W2912233058 hasAuthorship W2912233058A5032994476 @default.
• W2912233058 hasAuthorship W2912233058A5033768584 @default.
• W2912233058 hasAuthorship W2912233058A5041072453 @default.
• W2912233058 hasAuthorship W2912233058A5041589223 @default.
• W2912233058 hasAuthorship W2912233058A5041847366 @default.
• W2912233058 hasAuthorship W2912233058A5045169060 @default.
• W2912233058 hasAuthorship W2912233058A5050958883 @default.
• W2912233058 hasAuthorship W2912233058A5055269851 @default.
• W2912233058 hasAuthorship W2912233058A5073585994 @default.
• W2912233058 hasAuthorship W2912233058A5081104410 @default.
• W2912233058 hasAuthorship W2912233058A5083296540 @default.

• next