FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912233250> ?p ?o ?g. }

• W2912233250 abstract "Four new monomeric Pd (II) complexes with formulas [Pd(C,N)‐(2′‐NH 2 C 6 H 4 )C 6 H 4 (N 3 )(L)] ( A ), ( B ) and [Pd(C,N)‐C 6 H 4 CH 2 NH(C 4 H 9 )(N 3 )(L)] ( C ), ( D ), [L = isonicotinamide for ( A ) and ( C ), L = 4‐N,N‐dimethylaminopyridine for ( B ) and ( D )] have been synthesized using four initial dimers [Pd 2 {(C,N)‐(2′‐NH 2 C 6 H 4 )C 6 H 4 } 2 (μ‐OAc) 2 ] ( 1 ), [Pd 2 {(C,N)‐ (2′‐NH 2 C 6 H 4 )C 6 H 4 } 2 (μ‐N 3 ) 2 ] ( 3 ) for A and C , and [Pd 2 {(C,N)‐C 6 H 4 CH 2 NH(C 4 H 9 )} 2 (μ‐OAc) 2 ] ( 2 ) and [Pd 2 {(C,N)‐C 6 H 4 CH 2 NH(C 4 H 9 )} 2 (μ‐N 3 ) 2 ] ( 4 ) for B and D . Then synthesized complexes have been characterized by Fourier transform‐infrared, NMR spectroscopy and thermal gravimetric‐differential thermal analysis. Furthermore, UV–Vis spectroscopy, fluorescence spectroscopy, circular dichroism (CD) and helix melting temperature measurements have been employed to study the binding interaction of them with calf thymus‐deoxyribonucleic acid (DNA). The results reveal that all synthesized complexes can interact with DNA via groove‐binding mode. Bovine serum albumin (BSA)‐binding studies have been carried out using UV–Vis spectroscopy, emission titration and CD. However, competitive binding studies using warfarin, ibuprofen and digoxin on site markers demonstrated that the complexes bind to different sites on BSA. The results also indicated that the binding site was mainly located within site‐III for complex A , and site‐I for complexes B , C and D of BSA. In addition, molecular docking studies have been executed to determine the binding site of the DNA and BSA with complexes. Eventually, in vitro cytotoxicity of synthesized palladium complexes and cisplatin were carried out against human promyelocytic leukemia cancer (Hela) and breast cancer (MCF‐7) cell lines. Pursuant to the IC 50 values, the cytotoxicity of complexes against MCF‐7 was more than Hela." @default.
• W2912233250 created "2019-02-21" @default.
• W2912233250 creator A5008022983 @default.
• W2912233250 creator A5048528640 @default.
• W2912233250 creator A5077647300 @default.
• W2912233250 date "2019-01-22" @default.
• W2912233250 modified "2023-10-15" @default.
• W2912233250 title "Synthesis, characterization and molecular docking of new <i>C,N</i>‐palladacycles containing pyridinium‐derived ligands: DNA and BSA interaction studies and evaluation as anti‐tumor agents" @default.
• W2912233250 cites W1890488616 @default.
• W2912233250 cites W1966414423 @default.
• W2912233250 cites W1967067937 @default.
• W2912233250 cites W1967858190 @default.
• W2912233250 cites W1969231631 @default.
• W2912233250 cites W1969462016 @default.
• W2912233250 cites W1975199398 @default.
• W2912233250 cites W1975712438 @default.
• W2912233250 cites W1976325773 @default.
• W2912233250 cites W1976436661 @default.
• W2912233250 cites W1988088434 @default.
• W2912233250 cites W1989371402 @default.
• W2912233250 cites W1992947617 @default.
• W2912233250 cites W1993705187 @default.
• W2912233250 cites W1995451696 @default.
• W2912233250 cites W1998948607 @default.
• W2912233250 cites W1999235659 @default.
• W2912233250 cites W2001094457 @default.
• W2912233250 cites W2001218416 @default.
• W2912233250 cites W2001907362 @default.
• W2912233250 cites W2003130526 @default.
• W2912233250 cites W2004006450 @default.
• W2912233250 cites W2004738995 @default.
• W2912233250 cites W2005794341 @default.
• W2912233250 cites W2005795679 @default.
• W2912233250 cites W2005796784 @default.
• W2912233250 cites W2007579635 @default.
• W2912233250 cites W2008921799 @default.
• W2912233250 cites W2014516746 @default.
• W2912233250 cites W2026725853 @default.
• W2912233250 cites W2030730924 @default.
• W2912233250 cites W2034379846 @default.
• W2912233250 cites W2036482403 @default.
• W2912233250 cites W2038822441 @default.
• W2912233250 cites W2039305291 @default.
• W2912233250 cites W2041317621 @default.
• W2912233250 cites W2042680993 @default.
• W2912233250 cites W2046062888 @default.
• W2912233250 cites W2047122783 @default.
• W2912233250 cites W2048062787 @default.
• W2912233250 cites W2052597764 @default.
• W2912233250 cites W2055488128 @default.
• W2912233250 cites W2055488601 @default.
• W2912233250 cites W2057242176 @default.
• W2912233250 cites W2061082605 @default.
• W2912233250 cites W2062225334 @default.
• W2912233250 cites W2070034593 @default.
• W2912233250 cites W2073935135 @default.
• W2912233250 cites W2074731294 @default.
• W2912233250 cites W2075540003 @default.
• W2912233250 cites W2075663500 @default.
• W2912233250 cites W2076074152 @default.
• W2912233250 cites W2077192557 @default.
• W2912233250 cites W2079013013 @default.
• W2912233250 cites W2079164800 @default.
• W2912233250 cites W2094517427 @default.
• W2912233250 cites W2098147700 @default.
• W2912233250 cites W2102628934 @default.
• W2912233250 cites W2111699871 @default.
• W2912233250 cites W2112891180 @default.
• W2912233250 cites W2129995310 @default.
• W2912233250 cites W2141317254 @default.
• W2912233250 cites W2145538324 @default.
• W2912233250 cites W2146765462 @default.
• W2912233250 cites W2148550663 @default.
• W2912233250 cites W2151706170 @default.
• W2912233250 cites W2171733374 @default.
• W2912233250 cites W2188463161 @default.
• W2912233250 cites W2236136189 @default.
• W2912233250 cites W2263677373 @default.
• W2912233250 cites W2314240792 @default.
• W2912233250 cites W2325751025 @default.
• W2912233250 cites W2325878452 @default.
• W2912233250 cites W2331176150 @default.
• W2912233250 cites W2536192401 @default.
• W2912233250 cites W2591618257 @default.
• W2912233250 cites W2787513601 @default.
• W2912233250 cites W327629993 @default.
• W2912233250 doi "https://doi.org/10.1002/aoc.4728" @default.
• W2912233250 hasPublicationYear "2019" @default.
• W2912233250 type Work @default.
• W2912233250 sameAs 2912233250 @default.
• W2912233250 citedByCount "22" @default.
• W2912233250 countsByYear W29122332502019 @default.
• W2912233250 countsByYear W29122332502020 @default.
• W2912233250 countsByYear W29122332502021 @default.
• W2912233250 countsByYear W29122332502022 @default.
• W2912233250 countsByYear W29122332502023 @default.
• W2912233250 crossrefType "journal-article" @default.
• W2912233250 hasAuthorship W2912233250A5008022983 @default.
• W2912233250 hasAuthorship W2912233250A5048528640 @default.
• W2912233250 hasAuthorship W2912233250A5077647300 @default.

• next