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- W2912233410 abstract "Component C7 is a single-chain plasma glycoprotein of Mr∼97,000 that participates in the formation of the membrane attack complex (MAC). This macromolecular structure consists of C5b through C9, and it creates a transmembrane pore with a diameter of ∼100 Å. The polypeptide chain of C7 consists of a single domain of about 240 amino acids known as the MACPF, which is homologous to similar domains in C6, C8, C9 and perforin, along with eight cysteine-rich modules (34–75 amino acids). The C-terminal modules enable C7 to bind C5b, resulting in the C5b7 complex that acquires the ability to integrate to phospholipid membranes. Subsequent addition of C8 and C9 finalise the MAC. The gene for C7 is closely linked to that of C6 on chromosome 5. The importance of C7 for the host defence is illustrated by rare genetic deficiencies of C7 that make human subjects susceptible to neisserial infections." @default.
- W2912233410 created "2019-02-21" @default.
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- W2912233410 date "2018-01-01" @default.
- W2912233410 modified "2023-09-25" @default.
- W2912233410 title "C7" @default.
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- W2912233410 doi "https://doi.org/10.1016/b978-0-12-810420-0.00020-1" @default.
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