Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912233449> ?p ?o ?g. }
- W2912233449 endingPage "73" @default.
- W2912233449 startingPage "64" @default.
- W2912233449 abstract "Low homocysteine levels and B vitamin treatment are reported to protect against declining cognitive health. Both B vitamins and homocysteine are involved in the production of S-adenosylmethionine, a universal methyl donor essential for the process of DNA methylation. We investigated the effect of a damaging coding variant within the DNA methyltransferase gene DNMT3L (R278G, A/G) by examining B vitamin intake, homocysteine levels, cognitive performance, and brain atrophy in individuals in the VITACOG study of mild cognitive impairment and the TwinsUK cohort. In the VITACOG study, individuals who received a 2-year treatment of B vitamins and carried the G allele showed better “visuospatial associative memory” and slower rates of brain atrophy. In the TwinsUK study, improved “visuospatial associative memory” was evident in individuals who reported regular vitamin intake and were A/A homozygotes. In silico modeling indicated that R278G disrupts protein interaction between DNMT3L and DNMT3A, affecting the DNMT3A-3L-H3 complex required for DNA methylation. These findings show that vitamin intake and genetic variation within DNMT3L interact to influence cognitive decline." @default.
- W2912233449 created "2019-02-21" @default.
- W2912233449 creator A5004195948 @default.
- W2912233449 creator A5013708915 @default.
- W2912233449 creator A5030330229 @default.
- W2912233449 creator A5063798423 @default.
- W2912233449 creator A5064265369 @default.
- W2912233449 creator A5067209850 @default.
- W2912233449 creator A5077501796 @default.
- W2912233449 date "2019-06-01" @default.
- W2912233449 modified "2023-10-17" @default.
- W2912233449 title "Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline" @default.
- W2912233449 cites W1962552915 @default.
- W2912233449 cites W1975273337 @default.
- W2912233449 cites W1980584599 @default.
- W2912233449 cites W1981064450 @default.
- W2912233449 cites W1981354816 @default.
- W2912233449 cites W1997453048 @default.
- W2912233449 cites W1999835723 @default.
- W2912233449 cites W2000156285 @default.
- W2912233449 cites W2001621281 @default.
- W2912233449 cites W2002153924 @default.
- W2912233449 cites W2012034410 @default.
- W2912233449 cites W2016370157 @default.
- W2912233449 cites W2016461803 @default.
- W2912233449 cites W2016897727 @default.
- W2912233449 cites W2022689242 @default.
- W2912233449 cites W2023490488 @default.
- W2912233449 cites W2029237434 @default.
- W2912233449 cites W2031379951 @default.
- W2912233449 cites W2038449573 @default.
- W2912233449 cites W2039217834 @default.
- W2912233449 cites W2040692117 @default.
- W2912233449 cites W2043267753 @default.
- W2912233449 cites W2047573503 @default.
- W2912233449 cites W2053879278 @default.
- W2912233449 cites W2055655674 @default.
- W2912233449 cites W2064451824 @default.
- W2912233449 cites W2068194528 @default.
- W2912233449 cites W2076312647 @default.
- W2912233449 cites W2078758445 @default.
- W2912233449 cites W2084118479 @default.
- W2912233449 cites W2086461219 @default.
- W2912233449 cites W2089417246 @default.
- W2912233449 cites W2108664872 @default.
- W2912233449 cites W2111583472 @default.
- W2912233449 cites W2112152087 @default.
- W2912233449 cites W2113198638 @default.
- W2912233449 cites W2115818350 @default.
- W2912233449 cites W2138515203 @default.
- W2912233449 cites W2144392607 @default.
- W2912233449 cites W2147176795 @default.
- W2912233449 cites W2149816812 @default.
- W2912233449 cites W2152197344 @default.
- W2912233449 cites W2152451432 @default.
- W2912233449 cites W2153652414 @default.
- W2912233449 cites W2156635660 @default.
- W2912233449 cites W2165136235 @default.
- W2912233449 cites W2167512826 @default.
- W2912233449 cites W2203006631 @default.
- W2912233449 cites W2256016639 @default.
- W2912233449 cites W2262614321 @default.
- W2912233449 cites W2275047608 @default.
- W2912233449 cites W2558046424 @default.
- W2912233449 cites W2775081856 @default.
- W2912233449 doi "https://doi.org/10.1016/j.neurobiolaging.2019.02.001" @default.
- W2912233449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30877840" @default.
- W2912233449 hasPublicationYear "2019" @default.
- W2912233449 type Work @default.
- W2912233449 sameAs 2912233449 @default.
- W2912233449 citedByCount "7" @default.
- W2912233449 countsByYear W29122334492019 @default.
- W2912233449 countsByYear W29122334492021 @default.
- W2912233449 countsByYear W29122334492022 @default.
- W2912233449 countsByYear W29122334492023 @default.
- W2912233449 crossrefType "journal-article" @default.
- W2912233449 hasAuthorship W2912233449A5004195948 @default.
- W2912233449 hasAuthorship W2912233449A5013708915 @default.
- W2912233449 hasAuthorship W2912233449A5030330229 @default.
- W2912233449 hasAuthorship W2912233449A5063798423 @default.
- W2912233449 hasAuthorship W2912233449A5064265369 @default.
- W2912233449 hasAuthorship W2912233449A5067209850 @default.
- W2912233449 hasAuthorship W2912233449A5077501796 @default.
- W2912233449 hasBestOaLocation W29122334492 @default.
- W2912233449 hasConcept C104317684 @default.
- W2912233449 hasConcept C126322002 @default.
- W2912233449 hasConcept C134018914 @default.
- W2912233449 hasConcept C150194340 @default.
- W2912233449 hasConcept C15744967 @default.
- W2912233449 hasConcept C169760540 @default.
- W2912233449 hasConcept C169900460 @default.
- W2912233449 hasConcept C190727270 @default.
- W2912233449 hasConcept C2777090595 @default.
- W2912233449 hasConcept C33288867 @default.
- W2912233449 hasConcept C41091548 @default.
- W2912233449 hasConcept C54355233 @default.
- W2912233449 hasConcept C552990157 @default.
- W2912233449 hasConcept C71924100 @default.