Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912233592> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2912233592 endingPage "272a" @default.
- W2912233592 startingPage "271a" @default.
- W2912233592 abstract "Exercise capacity during aging is strongly linked to life quality, morbidity and mortality. In a selectively-bred rat model of intrinsic aerobic phenotypes, low-capacity (LCR) compared to high-capacity running (HCR) rats exhibit increased rates of metabolic syndrome, adiposity, dyslipidemia, endothelial dysfunction, and insulin resistance. Previously, we showed that with aging HCR rats present greater mitochondrial turnover underlying higher cardiomyocyte energetic performance, sustained by preferential selection of lipids oxidation with improved control of acetyl-CoA (AcCoA) concentration. All these positive indexes decline with aging, but they are better preserved in HCR vs. LCR, parallel with healthier aging and extended longevity. To investigate systemic metabolism in main organs supplying substrates (fatty acids, glucose, ketone bodies) to the heart, untargeted metabolomics was performed in liver and serum of young and middle age female HCR and LCR rats. Multivariate statistics indicated a metabolome pattern in liver comprised by higher abundance of fatty acids (e.g., palmitic, palmitoleic, oleic) at similar levels of intermediates from glucose metabolism in HCR vs. LCR. As a function of age, the serum of HCR rats exhibited an enrichment in fatty acids (e.g., linoleic, palmitic, arachidic) consistent with the changes observed in liver's metabolome. Higher liver AMP levels in HCR vs. LCR suggest activation of AMPK signaling, in agreement with the enhanced autophagy/mitophagy observed in HCR. Importantly, the higher relative LCR/HCR fold-changes of acetylated intermediates, in both liver and serum, agrees with the idea of widespread increased acetylation, compatible with the higher concentration of AcCoA measured in cardiomyocytes from LCR vs. HCR. Metabolomics reveal systemic, organ-concerted (liver-serum-heart), metabolic remodeling compatible with higher energetic performance, better preserved mitochondrial turnover, preferential lipid oxidation, and improved control of acetylation in HCR leading to extended longevity and better functional capacity." @default.
- W2912233592 created "2019-02-21" @default.
- W2912233592 creator A5020291322 @default.
- W2912233592 creator A5024244986 @default.
- W2912233592 creator A5036417376 @default.
- W2912233592 creator A5055309835 @default.
- W2912233592 creator A5081264656 @default.
- W2912233592 creator A5090259955 @default.
- W2912233592 date "2019-02-01" @default.
- W2912233592 modified "2023-09-26" @default.
- W2912233592 title "Systemic Metabolomics and Mitochondrial Energetics in High- Compared to Low-Running Capacity Rats as a Function of Age" @default.
- W2912233592 doi "https://doi.org/10.1016/j.bpj.2018.11.1468" @default.
- W2912233592 hasPublicationYear "2019" @default.
- W2912233592 type Work @default.
- W2912233592 sameAs 2912233592 @default.
- W2912233592 citedByCount "0" @default.
- W2912233592 crossrefType "journal-article" @default.
- W2912233592 hasAuthorship W2912233592A5020291322 @default.
- W2912233592 hasAuthorship W2912233592A5024244986 @default.
- W2912233592 hasAuthorship W2912233592A5036417376 @default.
- W2912233592 hasAuthorship W2912233592A5055309835 @default.
- W2912233592 hasAuthorship W2912233592A5081264656 @default.
- W2912233592 hasAuthorship W2912233592A5090259955 @default.
- W2912233592 hasBestOaLocation W29122335921 @default.
- W2912233592 hasConcept C126322002 @default.
- W2912233592 hasConcept C134018914 @default.
- W2912233592 hasConcept C135870905 @default.
- W2912233592 hasConcept C21565614 @default.
- W2912233592 hasConcept C2777391703 @default.
- W2912233592 hasConcept C2777477808 @default.
- W2912233592 hasConcept C2778096610 @default.
- W2912233592 hasConcept C2779306644 @default.
- W2912233592 hasConcept C2779936771 @default.
- W2912233592 hasConcept C31532488 @default.
- W2912233592 hasConcept C44353895 @default.
- W2912233592 hasConcept C4733338 @default.
- W2912233592 hasConcept C543025807 @default.
- W2912233592 hasConcept C55493867 @default.
- W2912233592 hasConcept C555293320 @default.
- W2912233592 hasConcept C60644358 @default.
- W2912233592 hasConcept C62231903 @default.
- W2912233592 hasConcept C71924100 @default.
- W2912233592 hasConcept C82714985 @default.
- W2912233592 hasConcept C86803240 @default.
- W2912233592 hasConceptScore W2912233592C126322002 @default.
- W2912233592 hasConceptScore W2912233592C134018914 @default.
- W2912233592 hasConceptScore W2912233592C135870905 @default.
- W2912233592 hasConceptScore W2912233592C21565614 @default.
- W2912233592 hasConceptScore W2912233592C2777391703 @default.
- W2912233592 hasConceptScore W2912233592C2777477808 @default.
- W2912233592 hasConceptScore W2912233592C2778096610 @default.
- W2912233592 hasConceptScore W2912233592C2779306644 @default.
- W2912233592 hasConceptScore W2912233592C2779936771 @default.
- W2912233592 hasConceptScore W2912233592C31532488 @default.
- W2912233592 hasConceptScore W2912233592C44353895 @default.
- W2912233592 hasConceptScore W2912233592C4733338 @default.
- W2912233592 hasConceptScore W2912233592C543025807 @default.
- W2912233592 hasConceptScore W2912233592C55493867 @default.
- W2912233592 hasConceptScore W2912233592C555293320 @default.
- W2912233592 hasConceptScore W2912233592C60644358 @default.
- W2912233592 hasConceptScore W2912233592C62231903 @default.
- W2912233592 hasConceptScore W2912233592C71924100 @default.
- W2912233592 hasConceptScore W2912233592C82714985 @default.
- W2912233592 hasConceptScore W2912233592C86803240 @default.
- W2912233592 hasIssue "3" @default.
- W2912233592 hasLocation W29122335921 @default.
- W2912233592 hasOpenAccess W2912233592 @default.
- W2912233592 hasPrimaryLocation W29122335921 @default.
- W2912233592 hasRelatedWork W1606482986 @default.
- W2912233592 hasRelatedWork W191837386 @default.
- W2912233592 hasRelatedWork W1999003826 @default.
- W2912233592 hasRelatedWork W2028009073 @default.
- W2912233592 hasRelatedWork W2061565738 @default.
- W2912233592 hasRelatedWork W2091730131 @default.
- W2912233592 hasRelatedWork W2140792307 @default.
- W2912233592 hasRelatedWork W2184857457 @default.
- W2912233592 hasRelatedWork W2370591872 @default.
- W2912233592 hasRelatedWork W4293597390 @default.
- W2912233592 hasVolume "116" @default.
- W2912233592 isParatext "false" @default.
- W2912233592 isRetracted "false" @default.
- W2912233592 magId "2912233592" @default.
- W2912233592 workType "article" @default.