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• W2912234050 endingPage "035004" @default.
• W2912234050 startingPage "035004" @default.
• W2912234050 abstract "Acellular dermal matrix (ADM) and platelet-rich plasma (PRP) have each been used in wound healing. There are a few reports on the application of ADM with PRP in skin full-thickness defect models. In this study, the microstructure of ADM/PRP freeze-dried dressing was observed by scanning electron microscope. The PRP, ADM and PRP/ADM samples were recorded by Fourier transform infrared (FTIR) spectrometer by the KBr methods. The concentration of growth factor was measured by enzyme-linked immunosorbent assay. Then, we made a mice full-thickness defect model and treated it with saline, PRP, ADM and PRP/ADM, respectively. The wound size was measured and calculated on days 3, 5, 7, 10 and 14. The obtained results demonstrated that the ADM/PRP freeze-dried dressing resulted in earlier collagen development. FTIR analysis confirmed the integration of ADM and PRP in the prepared PRP/ADM scaffold. The concentration of bFGF, EGF, TGF-β1 and PDGF-BB in the ADM/PRP group was lower than that in the PRP group. The wound healing rate of the ADM/PRP group was significantly promoted. Furthermore, the ADM/PRP group had significant revascularization, rapid epithelialization and a well-differentiated epidermis. The collagen fibers were regularly arranged. Accordingly, ADM/PRP freeze-dried dressing promotes wound healing and can be used in the skin full-thickness wound." @default.
• W2912234050 created "2019-02-21" @default.
• W2912234050 creator A5029283324 @default.
• W2912234050 creator A5036614827 @default.
• W2912234050 creator A5075512039 @default.
• W2912234050 creator A5079831593 @default.
• W2912234050 creator A5085888523 @default.
• W2912234050 date "2019-03-07" @default.
• W2912234050 modified "2023-10-18" @default.
• W2912234050 title "Preparation of ADM/PRP freeze-dried dressing and effect of mice full-thickness skin defect model" @default.
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• W2912234050 doi "https://doi.org/10.1088/1748-605x/ab0060" @default.
• W2912234050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30665205" @default.
• W2912234050 hasPublicationYear "2019" @default.
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