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• W2912234269 endingPage "178" @default.
• W2912234269 startingPage "157" @default.
• W2912234269 abstract "Uterine fibroids are the most common gynecological disorder, classically requiring surgery when symptomatic. Although attempts at finding a nonsurgical cure date back to centuries, it is only around the middle of the last century that serious attempts at a medical treatment were carried out. Initially, both progestins and estrogen-progestin combinations have been utilized, although proof of their usefulness is lacking. A major step forward was achieved when peptide analogs of the GnRH were introduced, first those with superagonist properties and subsequently those acting as antagonists. Initially, the latter produced side effects preventing their routine utilization; eventually, this problem was overcome following the synthesis of cetrorelix. Because both types of analogs produce hypoestrogenism, their use is limited to a maximum of 6 months and, for this reason, today they are utilized as an adjuvant treatment before surgery with overall good results. Over the last decade, new, nonpeptidic, orally active GnRH-receptor blockers have also been synthesized. One of them, Elagolix, is in the early stages of testing in women with fibroids. Another fundamental development has been the utilization of the so-called selective progesterone receptor modulators, sometimes referred to as antiprogestins. The first such compound to be applied to the long-term treatment of fibroids was Mifepristone; today, this compound is mostly used outside of Western Countries, where the substance of choice is Ulipristal acetate. Large clinical trials have proven the effectiveness of Ulipristal in the long-term medical therapy of fibroids, although some caution must be exercised because of the rare occurrence of liver complications. All selective progesterone receptor modulators produce unique endometrial changes that are today considered benign, reversible, and without negative consequences. In conclusion, long-term medical treatment of fibroids seems possible today, especially in premenopausal women." @default.
• W2912234269 created "2019-02-21" @default.
• W2912234269 creator A5019225467 @default.
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• W2912234269 creator A5077003520 @default.
• W2912234269 creator A5085675817 @default.
• W2912234269 date "2019-01-01" @default.
• W2912234269 modified "2023-10-12" @default.
• W2912234269 title "<p>Uterine fibroids: an update on current and emerging medical treatment options</p>" @default.
• W2912234269 cites W1120214604 @default.
• W2912234269 cites W134547284 @default.
• W2912234269 cites W141632864 @default.
• W2912234269 cites W1529794801 @default.
• W2912234269 cites W1531102169 @default.
• W2912234269 cites W1583068547 @default.
• W2912234269 cites W1586318876 @default.
• W2912234269 cites W1802161029 @default.
• W2912234269 cites W1816981042 @default.
• W2912234269 cites W1827097019 @default.
• W2912234269 cites W1853819257 @default.
• W2912234269 cites W1888084970 @default.
• W2912234269 cites W1913675875 @default.
• W2912234269 cites W1914327427 @default.
• W2912234269 cites W1969068003 @default.
• W2912234269 cites W1969985123 @default.
• W2912234269 cites W1970853200 @default.
• W2912234269 cites W1975323045 @default.
• W2912234269 cites W1981593539 @default.
• W2912234269 cites W1982426316 @default.
• W2912234269 cites W1982840326 @default.
• W2912234269 cites W1983768667 @default.
• W2912234269 cites W1984592479 @default.
• W2912234269 cites W1986704227 @default.
• W2912234269 cites W1986914259 @default.
• W2912234269 cites W1987244077 @default.
• W2912234269 cites W1987856923 @default.
• W2912234269 cites W1988084300 @default.
• W2912234269 cites W1988116546 @default.
• W2912234269 cites W1991353257 @default.
• W2912234269 cites W1991527171 @default.
• W2912234269 cites W1996100965 @default.
• W2912234269 cites W1996870092 @default.
• W2912234269 cites W2001262571 @default.
• W2912234269 cites W2004836636 @default.
• W2912234269 cites W2008203144 @default.
• W2912234269 cites W2008686181 @default.
• W2912234269 cites W2012011894 @default.
• W2912234269 cites W2016580581 @default.
• W2912234269 cites W2016927496 @default.
• W2912234269 cites W2017958278 @default.
• W2912234269 cites W2018694943 @default.
• W2912234269 cites W2022079794 @default.
• W2912234269 cites W2023776222 @default.
• W2912234269 cites W2026194341 @default.
• W2912234269 cites W2026392453 @default.
• W2912234269 cites W2026731274 @default.
• W2912234269 cites W2029276653 @default.
• W2912234269 cites W2029994287 @default.
• W2912234269 cites W2030452343 @default.
• W2912234269 cites W2031634538 @default.
• W2912234269 cites W2031966918 @default.
• W2912234269 cites W2032370413 @default.
• W2912234269 cites W2035366757 @default.
• W2912234269 cites W2037836317 @default.
• W2912234269 cites W2038250019 @default.
• W2912234269 cites W2038337167 @default.
• W2912234269 cites W2038484714 @default.
• W2912234269 cites W2039633328 @default.
• W2912234269 cites W2040011148 @default.
• W2912234269 cites W2040191669 @default.
• W2912234269 cites W2040352396 @default.
• W2912234269 cites W2040506471 @default.
• W2912234269 cites W2040523806 @default.
• W2912234269 cites W2041129970 @default.
• W2912234269 cites W2043006565 @default.
• W2912234269 cites W2044944561 @default.
• W2912234269 cites W2045180596 @default.
• W2912234269 cites W2046759896 @default.
• W2912234269 cites W2053715129 @default.
• W2912234269 cites W2055502966 @default.
• W2912234269 cites W2057333261 @default.
• W2912234269 cites W2057406042 @default.
• W2912234269 cites W2058537302 @default.
• W2912234269 cites W2059148312 @default.
• W2912234269 cites W2059317782 @default.
• W2912234269 cites W2059442967 @default.
• W2912234269 cites W2061347817 @default.
• W2912234269 cites W2064960854 @default.
• W2912234269 cites W2073068278 @default.
• W2912234269 cites W2073141863 @default.
• W2912234269 cites W2075213800 @default.
• W2912234269 cites W2076294496 @default.
• W2912234269 cites W2076668848 @default.
• W2912234269 cites W2078370543 @default.
• W2912234269 cites W2084467580 @default.
• W2912234269 cites W2085320423 @default.
• W2912234269 cites W2086189048 @default.

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