Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912236552> ?p ?o ?g. }
- W2912236552 abstract "Circadian rhythms that function in behaviour and physiology have adaptive significance for living organisms from bacteria to humans and reflect the presence of a biological clock. The engine of circadian rhythms is a transcription-translation feedback loop that is fine-tuned by epigenetic regulation in higher eukaryotes. We elucidated the chromatin structure of the Bmal1 gene, a critical component of the mammalian clock system, and have continued to investigate transcriptional regulation including DNA methylation. Various ailments including metabolic diseases can disrupt circadian rhythms, and many human diseases are associated with altered DNA methylation. Therefore, regulated circadian rhythms are important for human health. Here, we summarise the importance of epigenetic clock gene regulation, including DNA methylation of the Bmal1 gene, from the viewpoint of relationships to diseases." @default.
- W2912236552 created "2019-02-21" @default.
- W2912236552 creator A5025606245 @default.
- W2912236552 creator A5077083192 @default.
- W2912236552 date "2020-01-29" @default.
- W2912236552 modified "2023-10-18" @default.
- W2912236552 title "Epigenetic Modulation of Circadian Rhythms: Bmal1 Gene Regulation" @default.
- W2912236552 cites W1481045036 @default.
- W2912236552 cites W1798359211 @default.
- W2912236552 cites W1895114046 @default.
- W2912236552 cites W1930786993 @default.
- W2912236552 cites W1963842907 @default.
- W2912236552 cites W1964544156 @default.
- W2912236552 cites W1966377147 @default.
- W2912236552 cites W1976645327 @default.
- W2912236552 cites W1984091490 @default.
- W2912236552 cites W1986869256 @default.
- W2912236552 cites W1988185604 @default.
- W2912236552 cites W1990418876 @default.
- W2912236552 cites W1994994441 @default.
- W2912236552 cites W1997932809 @default.
- W2912236552 cites W1998585946 @default.
- W2912236552 cites W2002926593 @default.
- W2912236552 cites W2005052573 @default.
- W2912236552 cites W2012302008 @default.
- W2912236552 cites W2013578139 @default.
- W2912236552 cites W2015398239 @default.
- W2912236552 cites W2017403318 @default.
- W2912236552 cites W2019201641 @default.
- W2912236552 cites W2024450999 @default.
- W2912236552 cites W2025740950 @default.
- W2912236552 cites W2026343134 @default.
- W2912236552 cites W2027764072 @default.
- W2912236552 cites W2028449397 @default.
- W2912236552 cites W2035664969 @default.
- W2912236552 cites W2041136510 @default.
- W2912236552 cites W2042500733 @default.
- W2912236552 cites W2056651748 @default.
- W2912236552 cites W2059115988 @default.
- W2912236552 cites W2060550584 @default.
- W2912236552 cites W2067197383 @default.
- W2912236552 cites W2067657652 @default.
- W2912236552 cites W2078035790 @default.
- W2912236552 cites W2078600569 @default.
- W2912236552 cites W2079329544 @default.
- W2912236552 cites W2079891060 @default.
- W2912236552 cites W2083002423 @default.
- W2912236552 cites W2084770232 @default.
- W2912236552 cites W2088848161 @default.
- W2912236552 cites W2089056356 @default.
- W2912236552 cites W2089626640 @default.
- W2912236552 cites W2091531174 @default.
- W2912236552 cites W2091938363 @default.
- W2912236552 cites W2092647381 @default.
- W2912236552 cites W2095587967 @default.
- W2912236552 cites W2106249179 @default.
- W2912236552 cites W2110209988 @default.
- W2912236552 cites W2111162493 @default.
- W2912236552 cites W2121847288 @default.
- W2912236552 cites W2125600846 @default.
- W2912236552 cites W2130685024 @default.
- W2912236552 cites W2133918896 @default.
- W2912236552 cites W2135084584 @default.
- W2912236552 cites W2137252071 @default.
- W2912236552 cites W2140178312 @default.
- W2912236552 cites W2140400704 @default.
- W2912236552 cites W2141526271 @default.
- W2912236552 cites W2146421896 @default.
- W2912236552 cites W2147335424 @default.
- W2912236552 cites W2149902033 @default.
- W2912236552 cites W2150076905 @default.
- W2912236552 cites W2152497434 @default.
- W2912236552 cites W2153647097 @default.
- W2912236552 cites W2155260634 @default.
- W2912236552 cites W2155833731 @default.
- W2912236552 cites W2155859779 @default.
- W2912236552 cites W2157613001 @default.
- W2912236552 cites W2160589871 @default.
- W2912236552 cites W2161548459 @default.
- W2912236552 cites W2162641630 @default.
- W2912236552 cites W2163183531 @default.
- W2912236552 cites W2166404610 @default.
- W2912236552 cites W2167008303 @default.
- W2912236552 cites W2167027322 @default.
- W2912236552 cites W2191870832 @default.
- W2912236552 cites W220573480 @default.
- W2912236552 cites W2326008849 @default.
- W2912236552 cites W2331987929 @default.
- W2912236552 cites W2345988342 @default.
- W2912236552 cites W2505703250 @default.
- W2912236552 cites W2517930764 @default.
- W2912236552 cites W2560403139 @default.
- W2912236552 cites W2561960585 @default.
- W2912236552 cites W2613990381 @default.
- W2912236552 cites W2631752818 @default.
- W2912236552 cites W2726891392 @default.
- W2912236552 cites W2767620470 @default.
- W2912236552 cites W28955537 @default.
- W2912236552 doi "https://doi.org/10.5772/intechopen.79975" @default.
- W2912236552 hasPublicationYear "2020" @default.