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- W2912239047 abstract "The mitochondrial unspecific channel in Sacharomyces cerevisiae (ScMUC) is regulated by different substrates. It has been suggested that ScMUC opening is reversible and thus physiological. Its main function would be to eliminate cations or to partially uncouple the respiratory chain to prevent radical oxygen species (ROS) overproduction. ATP and low Pi open ScMUC, while Pi, Ca2+ and Mg2+ close it. Different groups propose other effectors such as NADH and some glycolysis intermediates, namely Fructose 1,6-biphosphate and glucose 6-phosphate). In our hands, ATP/ADP + Pi ratio seem to control opening reversibly. This would help confirm the physiological role of ScMUC, as it opens when energy in the cell is high. Thus, ScMUC would prevent prevent ROS overproduction" @default.
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- W2912239047 date "2019-02-01" @default.
- W2912239047 modified "2023-10-10" @default.
- W2912239047 title "The Reversible Opening of Muc Demonstrates a High Potential as a Cellular Protection System" @default.
- W2912239047 doi "https://doi.org/10.1016/j.bpj.2018.11.2259" @default.
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