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- W2912241065 abstract "Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by β-amyloid (Aβ) plaques and neurofibrillary tangles with progressive cognitive decline. After years of research with failed clinical trials surrounding Aβ and tau using numerous in vitro and in vivo AD transgenic animals, human model is necessary to advance our understanding of AD and drug discovery. Induced pluripotent stem cells (iPSCs) offers a novel approach for the establishment of a human model that reflects human genetics and physiology to investigate mechanisms of AD and other forms of dementia, which potentially could lead to a drug discovery, followed by treatment for the disease. In this review, I discuss the advantages in using iPSC technology with various forms of modeling, the progress that has been made to date in patient-derived AD iPSC model and challenges posed by using this technology. Finally, I suggest the future directions of disease modeling and the potential of iPSC technology in AD and other neurodegenerative research." @default.
- W2912241065 created "2019-02-21" @default.
- W2912241065 creator A5001384171 @default.
- W2912241065 date "2019-04-01" @default.
- W2912241065 modified "2023-09-25" @default.
- W2912241065 title "Human iPSC application in Alzheimer’s disease and Tau-related neurodegenerative diseases" @default.
- W2912241065 cites W150987474 @default.
- W2912241065 cites W1511517753 @default.
- W2912241065 cites W1526691126 @default.
- W2912241065 cites W1553983967 @default.
- W2912241065 cites W1671213273 @default.
- W2912241065 cites W1806909159 @default.
- W2912241065 cites W1848563179 @default.
- W2912241065 cites W1932303130 @default.
- W2912241065 cites W1973626590 @default.
- W2912241065 cites W1989038604 @default.
- W2912241065 cites W1994672714 @default.
- W2912241065 cites W2000497506 @default.
- W2912241065 cites W2009867508 @default.
- W2912241065 cites W2011885704 @default.
- W2912241065 cites W2014444260 @default.
- W2912241065 cites W2015246275 @default.
- W2912241065 cites W2018286352 @default.
- W2912241065 cites W2022532556 @default.
- W2912241065 cites W2023652080 @default.
- W2912241065 cites W2040027262 @default.
- W2912241065 cites W2040949523 @default.
- W2912241065 cites W2042883482 @default.
- W2912241065 cites W2051201963 @default.
- W2912241065 cites W2056145534 @default.
- W2912241065 cites W2064815984 @default.
- W2912241065 cites W2065309382 @default.
- W2912241065 cites W2073252618 @default.
- W2912241065 cites W2075701979 @default.
- W2912241065 cites W2081914422 @default.
- W2912241065 cites W2083922876 @default.
- W2912241065 cites W2086021621 @default.
- W2912241065 cites W2088714934 @default.
- W2912241065 cites W2089771991 @default.
- W2912241065 cites W2090139525 @default.
- W2912241065 cites W2094831055 @default.
- W2912241065 cites W2103659644 @default.
- W2912241065 cites W2105151327 @default.
- W2912241065 cites W2114840727 @default.
- W2912241065 cites W2115779804 @default.
- W2912241065 cites W2124317694 @default.
- W2912241065 cites W2126139369 @default.
- W2912241065 cites W2131108668 @default.
- W2912241065 cites W2138456699 @default.
- W2912241065 cites W2138574694 @default.
- W2912241065 cites W2143802939 @default.
- W2912241065 cites W2145356433 @default.
- W2912241065 cites W2146606376 @default.
- W2912241065 cites W2147718170 @default.
- W2912241065 cites W2153019619 @default.
- W2912241065 cites W2157073241 @default.
- W2912241065 cites W2159377066 @default.
- W2912241065 cites W2159422594 @default.
- W2912241065 cites W2161224111 @default.
- W2912241065 cites W2169926950 @default.
- W2912241065 cites W2176311229 @default.
- W2912241065 cites W2178051376 @default.
- W2912241065 cites W2195294260 @default.
- W2912241065 cites W2201698544 @default.
- W2912241065 cites W2282335838 @default.
- W2912241065 cites W2322302990 @default.
- W2912241065 cites W2343876552 @default.
- W2912241065 cites W2439312023 @default.
- W2912241065 cites W2465910223 @default.
- W2912241065 cites W2511608637 @default.
- W2912241065 cites W2516117108 @default.
- W2912241065 cites W2519209219 @default.
- W2912241065 cites W2525538087 @default.
- W2912241065 cites W2529866404 @default.
- W2912241065 cites W2530606728 @default.
- W2912241065 cites W2534142475 @default.
- W2912241065 cites W2582868206 @default.
- W2912241065 cites W2590949976 @default.
- W2912241065 cites W2592518050 @default.
- W2912241065 cites W2593638094 @default.
- W2912241065 cites W2601518322 @default.
- W2912241065 cites W2609844460 @default.
- W2912241065 cites W2611225933 @default.
- W2912241065 cites W2614953780 @default.
- W2912241065 cites W2617770907 @default.
- W2912241065 cites W2634812549 @default.
- W2912241065 cites W2735794637 @default.
- W2912241065 cites W2754890392 @default.
- W2912241065 cites W2768957663 @default.
- W2912241065 cites W2786430800 @default.
- W2912241065 cites W2793391328 @default.
- W2912241065 cites W2798230823 @default.
- W2912241065 cites W2804685648 @default.
- W2912241065 cites W2805798400 @default.
- W2912241065 cites W2886752110 @default.
- W2912241065 doi "https://doi.org/10.1016/j.neulet.2019.01.043" @default.
- W2912241065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30685408" @default.
- W2912241065 hasPublicationYear "2019" @default.